Biomarkers in Neoplastic Neuropathology

1. Front Matter

   Pages i-x

   PDF

2. Introduction

   • Fausto Rodriguez, Cheng-Ying Ho

   Pages 1-9

3. Special Techniques

   • Fausto Rodriguez, Cheng-Ying Ho

   Pages 11-44

4. Biobanking and Regulations

   • Fausto Rodriguez, Cheng-Ying Ho

   Pages 45-52

5. Public Databases

   • Fausto Rodriguez, Cheng-Ying Ho

   Pages 53-58

6. Biomarkers Applied to Specific Tumor Types

   • Fausto Rodriguez, Cheng-Ying Ho

   Pages 59-98

This book is a rich source of information on biomarkers applicable to the pathology of neoplastic disorders of the brain. Thorough descriptions are provided of the techniques currently available for clinical and experimental evaluation of biomarkers in brain neoplasms, including in situ hybridization, array-based methods, methylation profiling, next-generation sequencing, and practical gene panels. Incorporation of multiple biomarkers in the development of molecular subgroups with biologic and therapeutic relevance is also discussed. A section on biobanking covers the equally important topic of optimal preservation of tissue and includes consideration of ethical considerations raised by the use of tissue obtained in clinical settings. The closing section discusses the major categories of neoplastic disorders involving the nervous system, with emphasis on diagnostic, prognostic, and predictive biomarkers used in the pathologic evaluation of different types of brain tumor.

• Brain Tumor
• Gene Expression Profiling
• Immunohistochemistry
• Neurooncology
• Next generation sequencing

• Pathology, Johns Hopkins University, Baltimore, USA

  Fausto Rodriguez

• Pathology, Children’s National Medical Center, Washington, D.C., USA

  Cheng-Ying Ho

Fausto RodriguezJohn Hopkins University
Dept. of Pathology
Baltimore, MD
USA


Cheng-Ying Ho
Children's National Medical Center
Dept. of Pathology
Washington, DC
USA

Policies and ethics