Recent Advances in Retinoblastoma Treatment

1. Front Matter

   Pages i-x

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2. Molecular Biology of Retinoblastoma

   • Scott D. Walter, J. William Harbour

   Pages 1-13

3. Challenges of Genetic Susceptibility Testing for Retinoblastoma

   • Megan Harlan Fleischut

   Pages 15-26

4. Technique of Ophthalmic Artery Chemosurgery for Retinoblastoma

   • Y. Pierre Gobin

   Pages 27-36

5. Vitreous Disease and the Technique, Safety and Toxicity of Intravitreal Chemotherapy for Retinoblastoma

   • Jasmine H. Francis

   Pages 37-46

6. Electroretinogram Monitoring of Retinoblastoma Treatment

   • Scott E. Brodie

   Pages 47-59

7. Pharmacokinetics of Chemotherapy Delivered by Ophthalmic Artery Chemosurgery

   • Paula Schaiquevich, Guillermo L. Chantada

   Pages 61-72

8. Drug Discovery and Repurposing for Retinoblastoma

   • Bhavneet Bhinder, Jeni P. Mahida, Glorymar Ibáñez, Kathryn Champ, Christophe Antczak, Hakim Djaballah

   Pages 73-84

9. Management of High-Risk Retinoblastoma

   • Guillermo L. Chantada, María T. G. de Dávila

   Pages 85-96

10. Treatment of Extraocular Retinoblastoma

    • Ratna Behal, Ira J. Dunkel

    Pages 97-103

11. Second Tumors in Retinoblastoma Survivors

    • Ruth A. Kleinerman, Lindsay M. Morton, Jeannette R. Wong, Margaret A. Tucker

    Pages 105-112

12. Long-Term Follow-Up of Retinoblastoma Survivors

    • Danielle Novetsky Friedman

    Pages 113-121

13. Back Matter

    Pages 123-127

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This book is a comprehensive resource on the current understanding of retinoblastoma. It addresses all the essential aspects of retinoblastoma and its management, including: its molecular biology and genetics, management by focal treatment, intraarterial and intravitreal chemotherapy, electroretinogram monitoring of treatment, pharmacokinetic studies, high-risk features, treatment of metastatic disease, and long-term follow-up. The book represents a collaborative project involving ophthalmic oncologists, geneticists, pediatric oncologists, interventional neuroradiologists, electrophysiologists, and basic scientists who are at the forefront of their field. It is written in an accessible manner, and a wealth of tables, figures, and exemplary images are included to enhance the understanding of concepts.

• Electroretinogram
• Genetics of Retinoblastoma
• Intraarterial Chemotherapy
• Intravitreal Chemotherapy
• Pediatric Oncology

• Department of Ophthalmic Oncology, Memorial Sloan Kettering Cancer Center, New York, USA

  Jasmine H. Francis, David H. Abramson

Jasmine H. Francis, MD, is Assistant Attending in the Ophthalmic Oncology Service, Department of Surgery, Memorial Sloan-Kettering Cancer Center, New York and Adjunct Attending in the Department of Ophthalmology, New York Eye and Ear Infirmary, New York. Dr. Francis gained a BA in Neuroscience, magna cum laude, from Columbia University, New York in 2002 and graduated from New York University School of Medicine in 2007. She completed an Ophthalmology Residency at the New York Eye and Ear Infirmary in 2011, having been Chief Resident for the final year and receiving the William J. & Judith Turner Outstanding Resident Award. She went on to complete an Ophthalmic Oncology Fellowship at Memorial Sloan-Kettering Cancer Center in August 2013. She is a member of the International Society of Ocular Oncology, the American Academy of Pathology and Ocular Oncology, and the American Academy of Ophthalmology. Dr. Francis has published almost 30 articles in peer-reviewed journals as lead or co-author and presented many papers at national and international conferences.

 

David H. Abramson, MD, has been Professor of Ophthalmology at Cornell University Medical College, New York, since 2006. He was appointed to this position after being Clinical Professor of Ophthalmology at the college since 1984. He is Chief of the Ophthalmic Oncology Service, Department of Surgery at Memorial Sloan-Kettering Cancer Center, New York, and Attending Surgeon, Department of Surgery, Ophthalmic Oncology Service and Department of Pediatrics, Memorial Hospital for Cancer and Allied Diseases, New York. Dr. Abramson has been a Fellow of the American Academy of Ophthalmology and Otolaryngology since 1975 and a Fellow of the American College of Surgeons since 1977. He is Vice-President of the Ophthalmic Laser Surgical Society and the Manhattan Ophthalmic Society. Dr. Abramson has been the recipient of many honors and awards, including an AMA Physicians RecognitionAward, the 2004 Mildred Weisenfeld Award for Excellence in Ophthalmology, a Lifetime Achievement Award from the American Academy of Ophthalmology (2008), and the Stallard Medal from Cambridge University, Cambridge, UK. In 2012 he received the John Milton McClean Medal from Weill-Cornell Medical College and the Dominick Purpura Award – Outstanding Alumnus from Albert Einstein College of Medicine. He is the lead or co-author of 500 peer-reviewed journal articles as well as many other publications.

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