Overview
This book provides state-of-the-art reviews from key researchers in the field
Emphasizes how protein structure is informing a fuller understanding of receptor activity
Provides a comprehensive overview on nuclear receptors ?
Includes supplementary material: sn.pub/extras
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Table of contents (11 chapters)
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Front Matter
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Allosteric Regulation and Nuclear Receptor Complex Dynamics
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Front Matter
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Nuclear Receptor Co-regulatory Protein Interactions
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Front Matter
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Taking Nuclear Receptor Structure into the Clinic
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Front Matter
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Back Matter
Keywords
About this book
Nuclear Receptors focuses on the structural analysis of nuclear receptors from the initial work using isolated protein domains to the more recent exciting developments investigating the conformational shape of full-length receptor complexes. The book also reviews the structure of key nuclear receptor co-regulatory proteins. It brings together, for the first time, a comprehensive review of nuclear receptor structure and the importance of receptor conformation underpinning allosteric regulation by different ligands (hormone, drugs, DNA response elements, protein-protein interactions) and receptor activity.
The nuclear receptor superfamily, including receptors for steroid hormones and non-steroid ligands, are pivotal to normal physiology, regulating processes as diverse as reproduction, metabolism, the immune system and brain development. The first members of the family were cloned over 25 years ago, which heralded in the idea of a superfamily of intracellular receptor proteins that bound small molecule ligands: classical steroid hormones, vitamins, fatty acids and other products of metabolism. These signals are then transmitted through multiprotein receptor-DNA complexes, leading to the regulation of target genes, often in a cell-selective manner. The cloning of the receptor cDNAs also ushered in an era of unparalleled analysis of the mechanisms of action of these ligand-activated transcription factors.
Reviews
“Given the rapid advances in the field of nuclear receptor research, especially their role in cell proliferation, metabolism, and homeostasis, which make them prime targets for a wide range of diseases such as cancer and metabolic diseases, this book does an excellent job of covering their structure and function and translational opportunities for drug discovery. … The book targets students, scientists, and other clinicians such as oncologists and endocrinologists interested in the field of nuclear receptors.” (Omer Iqbal, Doody’s Book Reviews, October, 2015)
Editors and Affiliations
Bibliographic Information
Book Title: Nuclear Receptors: From Structure to the Clinic
Editors: Iain J. McEwan, Raj Kumar
DOI: https://doi.org/10.1007/978-3-319-18729-7
Publisher: Springer Cham
eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)
Copyright Information: Springer International Publishing Switzerland 2015
Hardcover ISBN: 978-3-319-18728-0Published: 29 August 2015
Softcover ISBN: 978-3-319-37128-3Published: 22 October 2016
eBook ISBN: 978-3-319-18729-7Published: 20 August 2015
Edition Number: 1
Number of Pages: XI, 236
Number of Illustrations: 10 b/w illustrations, 33 illustrations in colour
Topics: Human Genetics, Endocrinology, Human Physiology