Editors:
- Discusses varying hypotheses about CSCs to the overall development of CNS tumors
- Covers basic neuroscience, translational research aspects, and also includes recent SCS-specific treatment and strategies used in clinical research
- Appeals to cancer researchers, but also those who are involved in neuro-oncology
- Includes supplementary material: sn.pub/extras
Part of the book series: Advances in Experimental Medicine and Biology (AEMB, volume 853)
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Table of contents (9 chapters)
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Front Matter
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Back Matter
About this book
This volume presents the most current reviews on how cancer stem cells (CSCs) hypothesis dictates that the continued proliferation of a tumor is dependent on a sub-population of self-renewing and asymmetrically dividing neoplastic stem cells that supply a largely differentiated tumor. This volume provides a comprehensive overview of the characteristics of CSCs, their role in central nervous system (CNS) tumors, and the recent CSC-specific treatment modalities being used.
The emerging focus on CSCs in brain tumors represents a paradigm shift in our understanding of the pathogenesis of these neoplasms. Importantly, the realization that a distinct sub-population of cells contributes disproportionately to the growth and sustenance of central nervous system tumors has important implications for the treatment of such tumors. To treat CNS tumors, there is now a growing need to treat CSCs to achieve adequate tumor control.
Reviews
“This is an excellent textbook regarding the molecular and cell biology with respect to brain and spine neoplasms. This is a good book to look at and study if you are interested how cancer comes about. … Research neurologists and neurosurgeons will find the book useful for their animal research. … Graduate students, research fellows, and neuropathologists will be interested in the work presented here.” (Joseph J. Grenier, Amazon.com, August, 2015)
Editors and Affiliations
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Department of Neurosurgery, Vanderbilt University Medical Center, Nashville, USA
Moneeb Ehtesham
About the editor
Moneeb Ehtesham, M.D. is a Principal Investigator at the Department of Neurological Oncology at Vanderbilt University Medical Center. His research focuses on cellular therapies on malignant gliomas. He has published over 30 peer-reviewed publications, 3 book chapters, and 38 peer-reviewed abstracts/presentations. He has received over 1260 citations. Dr. Ehtesham has been awarded the Young Investigator Award (2003) by the American Association of Neurological Surgeons & Congress of Neurological Surgeons. He's also been listed in "Who's Who in Stem Cell Research" by DataTrend Publications.
Imad Khan, M.D. is a Research Associate at the Geisel School of Medicine at Dartmouth College. His research focuses on therapies for neurosurgical diseases and disorders. He has published over 30 peer-reviewed publications, 3 book chapters, and over 40 peer-reviewed abstracts/presentations.
Bibliographic Information
Book Title: Stem Cell Biology in Neoplasms of the Central Nervous System
Editors: Moneeb Ehtesham
Series Title: Advances in Experimental Medicine and Biology
DOI: https://doi.org/10.1007/978-3-319-16537-0
Publisher: Springer Cham
eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)
Copyright Information: The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Nature Switzerland AG 2015
Hardcover ISBN: 978-3-319-16536-3Published: 04 May 2015
Softcover ISBN: 978-3-319-34851-3Published: 09 October 2016
eBook ISBN: 978-3-319-16537-0Published: 20 April 2015
Series ISSN: 0065-2598
Series E-ISSN: 2214-8019
Edition Number: 1
Number of Pages: XIII, 190
Number of Illustrations: 1 b/w illustrations, 15 illustrations in colour
Topics: Cancer Research, Stem Cells, Neurosciences