Overview
- Serves a large number of scientists and clinicians who are interested in the normal and patho physiology of prolactin
- Gives an overview of major advances in the field of prolactin signaling pathways and regulation of prolactin gene expression
- Discusses the role of PRL in adipocytes, immune response, angiogenesis, as well as in prostate tumorogenesis
- Includes supplementary material: sn.pub/extras
Part of the book series: Advances in Experimental Medicine and Biology (AEMB, volume 846)
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Table of contents (13 chapters)
Keywords
About this book
Recent Advances in Prolactin Research summarizes the current knowledge of prolactin (PRL), PRL receptor, PRL-dependent signaling pathways, the role of PRL in oncogenesis and PRL crosstalk with other oncogenic factors. The chapters are written by experts in these fields and focus on identifying and reviewing timely experimental findings that provide new insights into the expanding role of PRL in the pathophysiology associated with a variety of human conditions.
Prolactin is a peptide hormone that is best known for its role in lactation. Prolactin also has an influence on hematopoiesis and angiogenesis, and is involved in the regulation of blood clotting through several pathways. Although PRL was discovered more than 80 years ago, the understanding of PRL signaling and its relationship to various pathologies is still very incomplete. PRL is not only a pituitary hormone with an important role in reproduction, but PRL also acts as a cytokine, modulating a wide variety of physiological processes. For example, data gathered during the last decade have demonstrated that locally produced PRL acts as the autocrine/paracrine factor and plays a contributory role during breast oncogenesis. In fact, the scientific and clinical communities have suggested that the manipulation of the PRL axis may lead to the successful treatment of breast cancer. However, recent work has demonstrated that the role of the PRL axis is much more complex than first envisaged.
Editors and Affiliations
Bibliographic Information
Book Title: Recent Advances in Prolactin Research
Editors: Maria Diakonova, PhD
Series Title: Advances in Experimental Medicine and Biology
DOI: https://doi.org/10.1007/978-3-319-12114-7
Publisher: Springer Cham
eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)
Copyright Information: The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Nature Switzerland AG 2015
Hardcover ISBN: 978-3-319-12113-0Published: 15 December 2014
Softcover ISBN: 978-3-319-35276-3Published: 23 August 2016
eBook ISBN: 978-3-319-12114-7Published: 03 December 2014
Series ISSN: 0065-2598
Series E-ISSN: 2214-8019
Edition Number: 1
Number of Pages: VIII, 281
Number of Illustrations: 9 b/w illustrations, 45 illustrations in colour
Topics: Human Physiology, Endocrinology, Biomedicine general