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Hormones, Intrauterine Health and Programming

  • Book
  • © 2014

Overview

Editors:
  1. Jonathan R Seckl

    1. Endocrinology Unit, University of Edinburgh Queen's Medical Research Inst, Edinburgh, United Kingdom

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  2. Yves Christen

    1. Fondation IPSEN, Boulogne-Billancourt Cedex, France

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  • Provides an accessible and cutting-edge view of this rapidly emerging field
  • Explains epidemiological associations between lower birth weight and a marked increase in the incidence of cardiac, metabolic and neuropsychiatric disorders from childhood to senescence
  • Presents the role of hormones and their links with other maternal environmental mediators in developmental programming
  • Includes supplementary material: sn.pub/extras

Part of the book series: Research and Perspectives in Endocrine Interactions (RPEI, volume 12)

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Table of contents (12 chapters)

  1. Front Matter

    Pages i-xiv
    Download chapter PDF

  2. Glucocorticoids and Fetal Programming; Necessary and Sufficient?

    • Jonathan R. Seckl
    Pages 1-15

  3. Developmental Programming and the Placenta: Focusing in on Glucocorticoids

    • Caitlin S. Wyrwoll
    Pages 17-26

  4. Glucocorticoids, Programming and the Transmission of Effects Across Generations

    • Amanda J. Drake
    Pages 27-40

  5. Maternal Stress and in Utero Programming

    • Louise C. Kenny, Claire Everard, Ali S. Khashan
    Pages 41-55

  6. The Role of the Placenta in Fetal Programming

    • John Challis, Debora Sloboda, Shaofu Li, Thorsten Braun, Frank Bloomfield, Ghazala Begum et al.
    Pages 57-69

  7. Male and Female Placentas Have Divergent Transcriptomic and Epigenomic Responses to Maternal Diets: Not Just Hormones

    • Anne Gabory, Alexandre Vigé, Laure Ferry, Linda Attig, Jean-Philippe Jais, Luc Jouneau et al.
    Pages 71-91

  8. Early Growth and Later Health: Findings from the Helsinki Birth Cohort Study

    • Johan G. Eriksson
    Pages 93-100

  9. Human Fetal Growth Disorders and Imprinting Anomalies

    • C. Gicquel, S. Azzi, S. Rossignol, J. Demars, F. Brioude, I. Netchine et al.
    Pages 101-129

  10. Epigenetic Effects of Extreme Intrauterine Growth in Humans

    • John M. Greally
    Pages 131-138

  11. Developmental Origins of Diabetes: The Role of Epigenetics

    • Rebecca A. Simmons
    Pages 139-156

  12. Genetic and Developmental Origins of Food Preferences and Obesity Risk: The Role of Dopamine

    • Patricia P. Silveira, James L. Kennedy, Marla B. Sokolowski, Robert D. Levitan, Michael J. Meaney
    Pages 157-174

  13. Developmental Epigenetics and Risks of Later Non-communicable Disease

    • M. A. Hanson, P. D. Gluckman, K. M. Godfrey
    Pages 175-183

  14. Back Matter

    Pages 185-189
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Keywords

About this book

The authors address in particular the role of hormones and their links with other maternal environmental mediators in developmental programming. The crucial nature of the placenta as an interface and target between maternal and foetal environments is addressed. Emphasis is made on the emerging science of epigenetics as a potential explanation for how environmental events that occur during brief windows of development may exert effects that impact upon somatic cells through many rounds of mitosis for much of the life span of the subsequent organism.

Editors and Affiliations

  • Endocrinology Unit, University of Edinburgh Queen's Medical Research Inst, Edinburgh, United Kingdom

    Jonathan R Seckl

  • Fondation IPSEN, Boulogne-Billancourt Cedex, France

    Yves Christen

About the editors

Jonathan Seckl is a Professor of Molecular Medicine at the University of Edinburgh, Endocrinology Unit, Centre for Cardiovascular Science at Queen's Medical Research Institute.

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