Overview
- Demonstrates how iron sources can be used by Mycobacterium tuberculosis and other mycobacteria
Part of the book series: SpringerBriefs in Molecular Science (BRIEFSMOLECULAR)
Part of the book sub series: SpringerBriefs in Biometals (SB BIOMETALS)
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Table of contents (5 chapters)
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Front Matter
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Back Matter
Keywords
About this book
Iron Acquisition by the Genus Mycobacterium summarizes the early evidence for the necessity of iron in mycobacteria and the discovery of the mycobacterial siderophores mycobactin, carboxymycobactin, and exochelin. The structural characterization of the mycobacterial siderophores is described.  The genes so far identified as essential for iron acquisition and maintenance of an infection by pathogenic mycobacteria are discussed. The potential role of siderocalin in iron gathering by M. tuberculosis is featured. Because new drugs for M. tuberculosis are needed, this brief also emphasizes the design of antibiotics that interfere with siderophore biosynthesis and the use of siderophore analogs and/or conjugates.
Editors and Affiliations
Bibliographic Information
Book Title: Iron Acquisition by the Genus Mycobacterium
Book Subtitle: History, Mechanisms, Role of Siderocalin, Anti-Tuberculosis Drug Development
Editors: B. Rowe Byers
Series Title: SpringerBriefs in Molecular Science
DOI: https://doi.org/10.1007/978-3-319-00303-0
Publisher: Springer Cham
eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)
Copyright Information: The Author(s) 2013
Softcover ISBN: 978-3-319-00302-3Published: 03 June 2013
eBook ISBN: 978-3-319-00303-0Published: 17 May 2013
Series ISSN: 2191-5407
Series E-ISSN: 2191-5415
Edition Number: 1
Number of Pages: V, 92
Number of Illustrations: 30 b/w illustrations, 9 illustrations in colour
Topics: Microbiology, Protein-Ligand Interactions, Inorganic Chemistry, Bioorganic Chemistry, Infectious Diseases