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Dementia in Parkinsonism

  • Conference proceedings
  • © 1997

Overview

Editors:
  1. S. E. Daniel

    1. Parkinson’s Disease Society Brain Research Centre (Brain Bank), Institute of Neurology, London, UK

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  2. F. F. Cruz-Sánchez

    1. Neurological Tissue Bank, Hospital Clinic, University of Barcelona, Spain

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  3. A. J. Lees

    1. Parkinson’s Disease Society Brain Research Centre (Brain Bank), Institute of Neurology, London, UK

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Part of the book series: Journal of Neural Transmission. Supplementa (NEURAL SUPPL, volume 51)

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Table of contents (15 papers)

  1. Front Matter

    Pages i-vi
    Download chapter PDF

  2. The language of the basal ganglia

    • G. Stern
    Pages 1-8

  3. Aging and the nigro-striatal pathway

    • F. F. Cruz-Sánchez, A. Cardozo, C. Castejón, E. Tolosa, M. L. Rossi
    Pages 9-25

  4. Psychiatric symptoms and behavioural disturbances in the dementias

    • A. Burns
    Pages 27-35

  5. PET and the investigation of dementia in the parkinsonian patient

    • N. Turjanski, D. J. Brooks
    Pages 37-48

  6. Neurofibrillary tangles and neuropil threads as a cause of dementia in Parkinson’s disease

    • H. Braak, E. Braak, D. Yilmazer, R. A. I. de Vos, E. N. H. Jansen, J. Bohl
    Pages 49-55

  7. Morphological substrates of dementia in parkinsonism A critical update

    • K. A. Jellinger
    Pages 57-82

  8. The Lewy body variant of Alzheimer disease

    • L. A. Hansen
    Pages 83-93

  9. Lewy body dementia — clinical, pathological and neurochemical interconnections

    • R. Perry, I. McKeith, E. Perry
    Pages 95-109

  10. Pathological diagnostic criteria for dementia associated with cortical Lewy bodies: review and proposal for a descriptive approach

    • J. Lowe, D. Dickson
    Pages 111-120

  11. Pathology of familial Alzheimer’s disease with Lewy bodies

    • T. Revesz, J. L. McLaughlin, M. N. Rossor, P. L. Lantos
    Pages 121-135

  12. Amyloid ß-peptide and its relationship with dementia in Lewy body disease

    • K. Jendroska, M. Kashiwagi, J. Sassoon, S. E. Daniel
    Pages 137-144

  13. Neurochemical abnormalities in Alzheimer’s disease and Parkinson’s disease — a comparative review

    • W. Gsell, I. Strein, U. Krause, P. Riederer
    Pages 145-159

  14. Apolipoprotein E gene in Parkinson’s disease, Lewy body dementia and Alzheimer’s disease

    • D. St. Clair
    Pages 161-165

  15. Indices of oxidative stress in Parkinson’s disease, Alzheimer’s disease and dementia with Lewy bodies

    • A. D. Owen, A. H. V. Schapira, P. Jenner, C. D. Marsden
    Pages 167-173

  16. Treatment of behavioural disturbances in Parkinson’s disease

    • F. Valldeoriola, F. A. Nobbe, E. Tolosa
    Pages 175-204
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Keywords

About this book

In his original essay on the shaking palsy (1817) James Parkinson remarked that the "senses and intellect were uninjured". Thus, it was only in later years that the complexity ofparkinsonism and in particular Parkinson's disease with dementia was recognised. Cognitive impairment in Parkinson's disease is common and is estimated to affect more than forty per cent of patients with disease onset after age 65. Recent studies suggest that pathology of Parkin­ son's disease now ranks second to Alzheimer's disease as the commonest sub­ strate of dementia in elderly patients. The condition is heterogeneous and there remain many complicated and unresolved questions concerning cause, diagnosis and classification. In an attempt to clarify these issues, scientists and members of the European Brain Bank Network (EBBN) gathered in London for a meeting entitled "Dementia in Parkinsonism". The resultant monograph is testimony to the wide-ranging clinical, morphological and biochemical aspects of this condition. We are grateful to all contributors for expressing their expert opinions and for being so generous with their time taken in prepa­ ration of the manuscripts. The meeting was funded by the Commission of the European Communities as part of a Biomed-l Programme. We wish to thank Amgen Limited, Lilly Industries Limited and Roche Products Limited for additional sponsorship. The expert secretarial assistance of R. Nani in the pre­ paration of this book has been very much appreciated. London, November 1997 S. E. Daniel F. F. Cruz-Sanchez A. J. Lees Contents Stern, G. : The language of the basal ganglia . . . . . . . . . . . . . . . . . . . . . .

Editors and Affiliations

  • Parkinson’s Disease Society Brain Research Centre (Brain Bank), Institute of Neurology, London, UK

    S. E. Daniel, A. J. Lees

  • Neurological Tissue Bank, Hospital Clinic, University of Barcelona, Spain

    F. F. Cruz-Sánchez

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