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Central Cholinergic Synaptic Transmission

  • Book
  • © 1989

Overview

Editors:
  1. Michael Frotscher

    1. Anatomisches Institut, J.W. Goethe-Universität, Frankurt a.M 70, Federal Republic of Germany

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  2. Ulrich Misgeld

    1. Max-Planck-Institut für Psychiatrie, Planegg-Martinsried, Federal Republic of Germany

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    You can also search for this editor in PubMed   Google Scholar

Part of the book series: Experientia Supplementum (EXS, volume 57)

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Table of contents (31 chapters)

  1. Front Matter

    Pages I-X
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  2. Cholinergic neurons, pathways and synapses

    1. Behavioral neuroanatomy of cholinergic innervation in the primate cerebral cortex

      • M.-Marsel Mesulam
      Pages 1-11

    2. Afferent connections of the forebrain cholinergic projection neurons, with special reference to monoaminergic and peptidergic fibers

      • Laszlo Zaborszky
      Pages 12-32

    3. Central cholinergic synapses: The septohippocampal system as a model

      • Michael Frotscher
      Pages 33-41

    4. Cholinergic-GABAergic synaptic interconnections in the rat amygdaloid complex: An electron microscopic double immunostaining study

      • L. Nitecka, M. Frostcher
      Pages 42-49

    5. Topography of βNGF receptor-positive and AChe-reactive neurons in the central nervous system

      • G. Raivich, G. W. Kreutzberg
      Pages 50-58

    6. Chol-1: A cholinergic-specific Gganglioside of possible significance in central nervous system neurochemistry and neuropathology

      • E. Borroni, E. Derrington, V. P. Whittaker
      Pages 59-67

  3. Acetylcholine-induced postsynaptic potentials and excitatory changes

    1. Pharmacological characterization of muscarinic responses in rat hippocampal pyramidal cells

      • P. Dutar, R. A. Nicoll
      Pages 68-76

    2. Mediation of acetylcholine’s excitatory actions in central neurons

      • N. Agopyan, K. Krnjević, J. Leblond
      Pages 77-87

    3. Presynaptic cholinergic action in the hippocampus

      • Menahem Segal, Varda Greenberger, Henry Markram
      Pages 88-96

    4. Opposing effects of acetylcholine on the two classes of voltage-dependent calcium channels in hippocampal neurons

      • M. Toselli, H. D. Lux
      Pages 97-103

    5. Muscarinic slow EPSPs in neostriatal and hippocampal neurons in vitro

      • U. Misgeld
      Pages 104-113

    6. Carbachol and pirenzepine discriminate effects mediated by two muscarinic receptor subtypes on hippocampal neurons in vitro

      • W. Müller, U. Misgeld
      Pages 114-122

    7. Cholinergic activation of medial pontine reticular formation neurons in vitro

      • R. W. Greene, H. L. Haas, U. Gerber, R. W. McCarley
      Pages 123-137

    8. Cholinergic responses in human neocortical neurones

      • J. V. Halliwell
      Pages 138-149

    9. Cholinergic modulation of hippocampal epileptic activity in vitro

      • Yoel Yaari, Morten S. Jensen
      Pages 150-158

    10. The cholinergic nucleus basalis: A key structure in neocortical arousal

      • György Buzsáki, Fred H. Gage
      Pages 159-171

    11. Cholinergic mechanisms in the telencephalon of cat and chicken

      • Christian M. Müller
      Pages 172-182

  4. Cholinergic receptor types and their modulation

    1. Central nicotinic acetylcholine receptors in the chicken and Drosophila CNS: Biochemical and molecular biology approaches

      • Heinrich Betz, Eckart D. Gundelfinger, Irm Hermans-Borgmeyer, Erich Sawruk, Patrick Schloß, Bertram Schmitt
      Pages 183-189

    2. Modulation of the sensitivity of nicotinic receptors in autonomic ganglia

      • Takashi Akasu, Takayuki Tokimasa
      Pages 190-196
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Keywords

About this book

Our knowledge of cholinergic synaptic transmission in the peripheral nervous system (PNS) has expanded enormously since the early 1930's, at which time O. Loewi discovered chemical neurotransmission through acetylcholine (ACh) and the pharmacological actions of ACh were described by H. Dale and his colleagues. Description of ACh's actions and receptors in various parts of the brain was followed by a detailed analysis of ACh's synthesis, release mechanism, removal from the synaptic cleft, modes of agonist-receptor interactions, properties of regulated conductances and of the pre-and postsynaptic modulation of cholinergic synapses. Our knowledge has been increasingly consolidat­ ing, leading us to the recent clarification of the structure of the periph­ eral nicotinic receptor-ion channel and its functional properties. It is appropriate to maintain the claim that the fundamentals of our under­ standing of synaptic transmission come from studies on cholinergic synapses in the PNS. Contrastingly, views held on the role of cholinergic synapses in the mammalian central nervous system (CNS) are extremely controversial, although it has been clear for some time that ACh is present in the brain. Illustrating this, no unanimous view is held on the role of nicotinic receptors in the CNS. There is one notable exception to this confusion: Studies begun by J. C. Eccles and associates in the 1960's and completed by D. R. Curtis and R. W.

Editors and Affiliations

  • Anatomisches Institut, J.W. Goethe-Universität, Frankurt a.M 70, Federal Republic of Germany

    Michael Frotscher

  • Max-Planck-Institut für Psychiatrie, Planegg-Martinsried, Federal Republic of Germany

    Ulrich Misgeld

Bibliographic Information

  • Book Title: Central Cholinergic Synaptic Transmission

  • Editors: Michael Frotscher, Ulrich Misgeld

  • Series Title: Experientia Supplementum

  • DOI: https://doi.org/10.1007/978-3-0348-9138-7

  • Publisher: Birkhäuser Basel

  • eBook Packages: Springer Book Archive

  • Copyright Information: Birkhäuser Verlag 1989

  • Softcover ISBN: 978-3-0348-9922-2Published: 27 September 2011

  • eBook ISBN: 978-3-0348-9138-7Published: 07 March 2013

  • Series ISSN: 1664-431X

  • Series E-ISSN: 2504-3692

  • Edition Number: 1

  • Number of Pages: X, 324

  • Topics: Science, Humanities and Social Sciences, multidisciplinary

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