T Cells in Arthritis

1. Front Matter

   Pages i-xii

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2. T cells as secondary players in rheumatoid arthritis

   • Katherine H. Y. Nguyen, Gary S. Firestein

   Pages 1-18

3. T cell receptor rearrangements in arthritis

   • David E. Fox, Nora G. Singer

   Pages 19-53

4. T cell-independent joint destruction

   • Juliane K. Franz, Thomas Pap, Ulf Müller-Ladner, Renate E. Gay, Gerd R. Burmester, Steffen Gay

   Pages 55-74

5. Role of T cells in arthritis: Lessons from animal models

   • Wim B. van den Berg

   Pages 75-92

6. The Th1/Th2 cytokine balance in arthritis

   • Pierre Miossec

   Pages 93-109

7. Interactions between T cell plasma membranes and monocytes

   • Danielle Burger, Jean-Michel Dayer

   Pages 111-128

8. Adhesion molecules in arthritis: Control of T cell migration into the synovium

   • Nancy Oppenheimer-Marks, Peter E. Lipsky

   Pages 129-148

9. T cell reactivity to Epstein-Barr virus in rheumatoid arthritis

   • Marc Bonneville, Emmanuel Scotet, Marie-Alix Peyrat, Annick Lim, Jacques David-Ameline, Elisabeth Houssaint

   Pages 149-167

10. T cell responses in reactive and Lyme arthritis

    • Joachim Sieper, Jürgen Braun

    Pages 169-187

11. T cell directed therapies and biologics

    • Ferdinand C. Breedveld

    Pages 189-199

12. T Cells as primary players in rheumatoid arthritis

    • Michael T. Falta, Brian L. Kotzin

    Pages 201-231

13. Back Matter

    Pages 233-236

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Rheumatoid arthritis (RA) is the most common and most severe form of inflammatory arthritis. The pathogenesis of RA has been the subject of intense research for several decades. The prevailing hypotheses have changed over the years, and have attempted to incorporate the most recent data. Although T cells represent an important component of the cells which infiltrate the joint synovium, their contribution at a late stage of the disease remains a matter of debate. The goal of this book is to outline the major arguments and data suggesting that T cells may, or may not, be central players in the pathogenesis of chronic RA. While each of the editors and authors has his/her own bias (as will be clear by reading the respective chapters), our hope is that the readers will enjoy a complete and balanced view of the critical questions and experiments. This is not just an intellectual exercise since the direction of future therapeutic interventions depends heavily on how one interprets the pathogenesis of RA and the contribution of T cells.

• cell
• rheumatism
• rheumatoid arthritis
• therapy
• virus

• Departments of Immunology and Rheumatology Hôpital Edouard Herriot, University Claude Bernard, Lyon Cedex 03, France

  Pierre Miossec

• Division of Rheumatology, UCSD School of Medicine, San Diego, USA

  Gary S. Firestein

• Department of Rheumatology, University Hospital Nijmegen, Nijmegen, The Netherlands

  Wim B. Berg

Policies and ethics