Anti-Inflammatory Drugs in Asthma

1. Front Matter

   Pages i-viii

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2. Anti-Inflammatory Drugs in Asthma: The Pathophysiology of Asthma

   • James L. Lordan, Ratko Djukanović

   Pages 1-33

3. Corticosteroids

   • Peter J. Barnes

   Pages 35-85

4. Phosphodiesterases in Asthma

   • Hermann Tenor, Christian Schudt

   Pages 87-135

5. β2-Agonists

   • Joanna S. Thompson Coon, Anne E. Tattersfield

   Pages 137-151

6. Mast Cell Stabilizing Drugs

   • Guy F. Joos, Renaat A. Peleman, Romain A. Pauwels

   Pages 153-167

7. Anti-Leukotriene Therapy for Asthma

   • Zuzana Diamant, Anthony P. Sampson

   Pages 169-197

8. Immunomodulators

   • Li Cher Loh, Neil C. Barnes

   Pages 199-214

9. Anti-IgE Agents

   • Francesco Patalano

   Pages 215-227

10. Mast Cell Proteases as New Targets for Therapeutic Intervention in Asthma

    • Steven J. Compton, Andrew F. Walls

    Pages 229-249

11. Cytokine and Adhesion Molecule Antagonists

    • Paul S. Foster, Simon P. Hogan

    Pages 251-272

12. Back Matter

    Pages 273-276

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For some years, international guidelines on the management of asthma have stressed the importance of early intervention with anti-inflammatory drugs to prevent acute asthma exacerbations and to avert chronic inflammatory damage to the airway. Introduced by a broad survey of the targets for anti-inflammatory drugs, this book proceeds to bring together the most recent research into the mechanisms and clinical benefits of presently available anti-inflammatory treatments including corticosteroids, cromones, and theophylline. For the first time, these drugs are discussed alongside the newly introduced leukotriene modifier drugs, and in the context of frontline research into anti-inflammatory drugs of the future. Leading authorities in their fields evaluate the prospects of novel anti-IgE agents and cytokine antagonists, and examine recent developments in immunosuppressant compounds, protease inhibitors, and selective phosphodiesterase inhibitors. This book is an up-to-date and authoritative survey which will be invaluable to university and pharmaceutical company researchers working on anti-asthma and anti-allergy drugs and to respiratory physicians keeping abreast of developments in their specialty.

• Atmen
• allergy
• asthma
• cytokine
• research
• steroids
• stress

• Immunopharmacology Group, Southampton General Hospital, Southampton, UK

  Anthony P. Sampson, Martin K. Church

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