Vascular Adhesion Molecules and Inflammation

1. Front Matter

   Pages i-ix

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2. How early studies of inflammation led to our current views on the roles of vascular adhesion molecules

   • Jeremy D. Pearson

   Pages 1-10

3. Adhesion of leukocytes from flow: The selectins and their ligands

   • Klaus Ley

   Pages 11-37

4. Co-operative signaling between leukocytes and endothelium mediating firm attachment

   • C. Wayne Smith, Alan R. Burns, Scott I. Simon

   Pages 39-64

5. Production and Presentation of Chemokines by Endothelial Cells

   • Martha B. Furie

   Pages 65-80

6. Platelet-activating factor: A signaling molecule for leukocyte adhesion

   • Diane E. Lorant, Thomas M. Mclntyre, Stephen M. Prescott, Guy A. Zimmerman

   Pages 81-107

7. Tight junctions and adherens junctions in endothelial Cells: structure and regulation

   • James M. Staddon, Tetsuaki Hirase

   Pages 109-124

8. The role of PECAM in leukocyte emigration

   • William A. Muller

   Pages 125-140

9. Selective lymphocyte migration into secondary lymphoid organs and inflamed tissues

   • Mark A. Jutila

   Pages 141-160

10. Oxidation-reduction sensitive regulation of vascular inflammatory gene expression

    • Xi-Lin Chen, Russell M. Medford

    Pages 161-178

11. Quantification and imaging of vascular adhesion molecule expression in inflammatory diseases in vivo

    • Tanya Y. Huehns, Dorian O. Haskard

    Pages 179-196

12. Leukocyte adhesion and activation in xenografts

    • Simon C. Robson, David Goodman

    Pages 197-219

13. Control of leukocyte adhesion and activation in ischemiareperfusion injury

    • Tak Yee Aw, D. Neil Granger

    Pages 221-238

14. Control of leukocyte adhesion and activation in atherogenesis

    • Judith A. Berliner, Devendra K. Vora, Peggy T. Shih

    Pages 239-256

15. Back Matter

    Pages 257-260

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The book will provide an overview of the roles of vascular adhesion molecules in health and disease, with chapters on their cell biology, followed by chapters reviewing their importance in specific disease processes. Vascular adhesion molecules are vital for the physiological processes of leukocyte trafficking and also critically involved in the enhanced leukocyte emigration that is a key feature of all inflammatory and immune diseases. The book is designed to provide up-to-date, linked reviews of the subject suitable for postgraduate students entering the field or research workers from allied disciplines needing a modern overview.

• biology
• cell
• cell biology
• diseases
• inflammation
• migration
• research

• Centre for Cardiovascular Biology and Medicine, School of Biomedical Sciences King’s College London, London, UK

  Jeremy D. Pearson

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