Overview
- Editors:
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Stephen T. Holgate
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School of Medicine IIR (Respiratory Cell and Molecular Biology) Division Southampton General Hospital, University of Southampton, Southampton, UK
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John W. Holloway
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School of Medicine Human Genetics and IIR (Respiratory Cell and Molecular Biology) Divisions, University of Southampton, Southampton, UK
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Table of contents (11 chapters)
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- Chaker N. Adra, X.-Q. Mao, A. Yamasaki, P-S. Gao, Xing Yang, T. Shirakawa et al.
Pages 85-93
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- Tineke C. T. M. van der Pouw Kraan, John W. Holloway, Lucien A. Aarden, Jaring S. van der Zee
Pages 95-111
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- Roy C. Levitt, Michael P McLane, Luigi Grasso, Nicholas C. Nicolaides
Pages 113-124
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- Hartmut Grasemann, Jeffrey M. Drazen
Pages 125-136
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- Ladina Joos, Peter D. Paré, Andrew J. Sandford
Pages 167-176
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Back Matter
Pages 177-181
About this book
Allergic diseases are complex and involve a range of environmental factors interacting with a susceptible genotype. The familial clustering of diseases, such as asthma and hay fever, has been recognised for over two centuries, but identification of the genetic basis to this had to await the molecular biological revolution. Estimates of the contribution that genetic factors make to asthma susceptibility range from 35% to 70%. For the majority of allergic diseases, segregation analysis has not identified a consistent Mendelian pattern of inheritance, which, when combined with multiple phenotypes and environmental interactions, has made identifying candidate genes especially difficult and, at times, controversial. Part of the difficulty has been lack of agreement over phenotype definitions, reduced power of studies to predict linkage and association, and, importantly, lack of true heterogeneity between populations. Despite these difficulties, the last decade has witnessed enormous progress in this field.
Editors and Affiliations
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School of Medicine IIR (Respiratory Cell and Molecular Biology) Division Southampton General Hospital, University of Southampton, Southampton, UK
Stephen T. Holgate
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School of Medicine Human Genetics and IIR (Respiratory Cell and Molecular Biology) Divisions, University of Southampton, Southampton, UK
John W. Holloway