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Circulating microRNAs in Disease Diagnostics and their Potential Biological Relevance

  • Book
  • © 2015

Overview

Editors:
  1. Peter Igaz

    1. 2nd Department of Medicine, Semmelweis University, Budapest, Hungary

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  • Discusses the diagnostic potential of circulating MicroRNAs
  • Presents hypotheses on the potential biological relevance of circulating microRNAs
  • Highlights the role of circulating microRNAs in epigenetics, tumor surveillance and interindvidual communication
  • Includes supplementary material: sn.pub/extras

Part of the book series: Experientia Supplementum (EXS, volume 106)

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Table of contents (14 chapters)

  1. Front Matter

    Pages i-xii
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  2. General Features and Technical Issues Related to Circulating microRNA

    1. Front Matter

      Pages 1-1
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    2. Introduction to microRNAs: Biogenesis, Action, Relevance of Tissue microRNAs in Disease Pathogenesis, Diagnosis and Therapy—The Concept of Circulating microRNAs

      • Zoltán Nagy, Peter Igaz
      Pages 3-30

    3. Extracellular microRNAs in Membrane Vesicles and Non-vesicular Carriers

      • Anna M. L. Coenen-Stass, Imre Mäger, Mathew J. A. Wood
      Pages 31-53

    4. Technical Aspects Related to the Analysis of Circulating microRNAs

      • Henriett Butz, Attila Patócs
      Pages 55-71

  3. Diagnostic Relevance of Circulating microRNAs

    1. Front Matter

      Pages 73-73
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    2. Circulating Blood-Borne microRNAs as Biomarkers in Solid Tumors

      • Petra Vychytilova-Faltejskova, Ondrej Slaby
      Pages 75-122

    3. Circulating microRNA as Biomarkers in Hematological Malignancies

      • Monika Stankova, Veronika Kubaczkova, Lenka Sedlarikova, Sabina Sevcikova
      Pages 123-138

    4. Circulating microRNAs as Biomarkers in Cardiovascular Diseases

      • Salvatore De Rosa, Ciro Indolfi
      Pages 139-149

    5. Circulating microRNAs in Neurodegenerative Diseases

      • Margherita Grasso, Paola Piscopo, Alessio Crestini, Annamaria Confaloni, Michela A. Denti
      Pages 151-169

    6. Circulating Extracellular microRNA in Systemic Autoimmunity

      • Niels H. H. Heegaard, Anting Liu Carlsen, Kerstin Skovgaard, Peter M. H. Heegaard
      Pages 171-195

    7. Circulating microRNAs in Inflammatory Bowel Diseases

      • Maria Gazouli
      Pages 197-214

    8. Circulating microRNAs in Diabetes Progression: Discovery, Validation, and Research Translation

      • Ryan J. Farr, Mugdha V. Joglekar, Anandwardhan A. Hardikar
      Pages 215-244

    9. Diagnostic Relevance of microRNAs in Other Body Fluids Including Urine, Feces, and Saliva

      • Ivan Igaz, Peter Igaz
      Pages 245-252

  4. Potential Biological Relevance of Circulating microRNA

    1. Front Matter

      Pages 253-253
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    2. Circulating microRNAs as Hormones: Intercellular and Inter-organ Conveyors of Epigenetic Information?

      • Yusuke Yoshioka, Takeshi Katsuda, Takahiro Ochiya
      Pages 255-267

    3. Are Circulating microRNAs Involved in Tumor Surveillance?

      • Ivan Igaz, Peter Igaz
      Pages 269-280

    4. Hypothetic Interindividual and Interspecies Relevance of microRNAs Released in Body Fluids

      • Ivan Igaz, Peter Igaz
      Pages 281-288
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Keywords

About this book

MicroRNAs as the endogenous mediators of RNA interference have experienced an unprecedented career in recent years, highlighting their pathogenic, diagnostic and potential therapeutic relevance. Beside tissue microRNAs, they are also found in body fluids, most notably in blood. Significant differences of circulating microRNA levels have been found in various diseases, making them candidates for minimally invasive markers of disease, for example tumor malignancy. The book focuses on the potential diagnostic applicability of circulating microRNAs in various diseases and their potential biological significance.

Editors and Affiliations

  • 2nd Department of Medicine, Semmelweis University, Budapest, Hungary

    Peter Igaz

About the editor

Peter Igaz has degrees in medicine and molecular biology. He works as an associate professor in medicine at Semmelweis University Budapest. He is very actively involved in research focusing on the genomics and bioinformatics of endocrine tumors; the study of microRNAs forms a special focus of his research. His research group was among the first to describe tissue microRNA profiles and microRNA biomarkers of malignancy in adrenocortical and adrenomedullary tumors, and circulating microRNAs in adrenocortical tumor patients. His group developed a novel microRNA target prediction algorithm and analyzed pathways involved in adrenal tumors with bioinformatics tools.

Bibliographic Information

  • Book Title: Circulating microRNAs in Disease Diagnostics and their Potential Biological Relevance

  • Editors: Peter Igaz

  • Series Title: Experientia Supplementum

  • DOI: https://doi.org/10.1007/978-3-0348-0955-9

  • Publisher: Springer Basel

  • eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)

  • Copyright Information: Springer International Publishing Switzerland 2015

  • Hardcover ISBN: 978-3-0348-0953-5Published: 02 December 2015

  • eBook ISBN: 978-3-0348-0955-9Published: 25 November 2015

  • Series ISSN: 1664-431X

  • Series E-ISSN: 2504-3692

  • Edition Number: 1

  • Number of Pages: XII, 288

  • Number of Illustrations: 3 b/w illustrations, 15 illustrations in colour

  • Topics: Gene Expression, Nucleic Acid Chemistry, Medical Biochemistry

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