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Multimodal Optical Diagnostics of Cancer

  • Introduces optical imaging strategies
  • Focuses on multimodal optical diagnostics as a fundamental approach
  • Discusses novel methods of optical non-invasive cancer diagnostics

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Table of contents (16 chapters)

  1. Front Matter

    Pages i-xx
  2. Tumor Tissue Optics and Multimodal Microscopy

    1. Front Matter

      Pages 1-1
    2. Malignant Tissue Optical Properties

      • Alexey N. Bashkatov, Valery P. Zakharov, Alla B. Bucharskaya, Ekaterina G. Borisova, Yulia A. Khristoforova, Elina A. Genina et al.
      Pages 3-106
    3. Optical Clearing of Biological Tissues: Prospects of Application for Multimodal Malignancy Diagnostics

      • Elina A. Genina, Luís M. C. Oliveira, Alexey N. Bashkatov, Valery V. Tuchin
      Pages 107-131
    4. Exploring Tumor Metabolism with Time-Resolved Fluorescence Methods: from Single Cells to a Whole Tumor

      • Marina V. Shirmanova, Vladislav I. Shcheslavskiy, Maria M. Lukina, Wolfgang Becker, Elena V. Zagaynova
      Pages 133-155
    5. Optical Imaging of Exosomes for Cancer Diagnosis, Monitoring, and Prognosis

      • Natalia V. Yunusova, Alexey V. Borisov, Yury V. Kistenev
      Pages 157-192
  3. Diffuse Spectroscopy and Fluorescence Analysis for Cancer Detection

    1. Front Matter

      Pages 193-193
    2. Functional Near-Infrared Spectroscopy in Cancer Diagnostics

      • Teemu Myllylä, Vesa Korhonen
      Pages 195-207
    3. Breathomics for Lung Cancer Diagnosis

      • Yury V. Kistenev, Alexey V. Borisov, Denis A. Vrazhnov
      Pages 209-243
  4. Raman Spectroscopy for Cancer Diagnostics

    1. Front Matter

      Pages 271-271
    2. Raman Spectroscopy and Advanced Statistics for Cancer Diagnostics

      • Nicole M. Ralbovsky, Igor K. Lednev
      Pages 273-323
    3. Raman Spectroscopy Techniques for Skin Cancer Detection and Diagnosis

      • Ivan A. Bratchenko, Dmitry N. Artemyev, Yulia A. Khristoforova, Lyudmila A. Bratchenko, Oleg O. Myakinin, Alexander A. Moryatov et al.
      Pages 359-393
  5. Multimodal Cancer Imaging

    1. Front Matter

      Pages 395-395
    2. Multimodal Optical Diagnostic in Minimally Invasive Surgery

      • Elena Potapova, Viktor Dremin, Evgeny Zherebtsov, Andrian Mamoshin, Andrey Dunaev
      Pages 397-424
    3. Multimodal OCT for Malignancy Imaging

      • Grigory Gelikonov, Valentin Gelikonov, Alexander Moiseev, Pavel Shilyagin, Sergey Ksenofontov, Irina Kasatkina et al.
      Pages 425-464
    4. Texture Analysis in Skin Cancer Tumor Imaging

      • Oleg O. Myakinin, Alexander G. Khramov, Dmitry S. Raupov, Semyon G. Konovalov, Sergey V. Kozlov, Alexander A. Moryatov
      Pages 465-504
    5. Application of Acousto-Optical Hyperspectral Imaging for Skin Cancer Diagnostics

      • Vitold E. Pozhar, Alexander S. Machikhin, Oleg O. Myakinin, Ivan A. Bratchenko
      Pages 505-536

About this book

This book provides an in-depth description and discussion of different multi-modal diagnostic techniques for cancer detection and treatment using exact optical methods, their comparison, and combination. Coverage includes detailed descriptions of modern state of design for novel methods of optical non-invasive cancer diagnostics; multi-modal methods for earlier cancer diagnostic enhancing the probability of effective cancer treatment; modern clinical trials with novel methods of clinical cancer diagnostics; medical and technical aspects of clinical cancer diagnostics, and long-term monitoring. Biomedical engineers, cancer researchers, and scientists will find the book to be an invaluable resource.

  • Introduces optical imaging strategies;
  • Focuses on multimodal optical diagnostics as a fundamental approach;
  • Discusses novel methods of optical non-invasive cancer diagnostics.


Editors and Affiliations

  • Department of Optics and Biophotonics, Saratov State University, Saratov, Russia

    Valery V. Tuchin

  • Leibniz-Institute of Photonic Technology e.V. and Institute of Physical Chemistry and Abbe Center of Photonics, University of Jena, Jena, Germany

    Jürgen Popp

  • Department of Laser and Biotechnical Systems, Samara National Research University, Samara, Russia

    Valery Zakharov

About the editors

Valery V. Tuchin is a professor and chairman of Optics and Biophotonics at Saratov National Research State University. He is also the head of laboratory, Institute of Precision Mechanics and Control, Russian Academy of Sciences, and the supervisor of Interdisciplinary laboratory of Biophotonics at National Research Tomsk State University. Dr. Tuchin is the editor of the Handbook of Coherent-Domain Optical Methods: Biomedical Diagnostics, Environmental Monitoring, and Materials Science (Springer). His research interests include biophotonics, tissue optics, laser medicine, tissue optical clearing, and nanobiophotonics. He is a guest professor of Huazhong University of Science and Technology (HUST) and Tianjin Universities of China, and adjunct professor at University of Limerick and National University of Ireland, Galway. He is member and fellow of SPIE and OSA, and a member of the IEEE.


Jürgen Popp studied chemistry at the Universitiesof Erlangen and Wuerzburg. After his PhD in Chemistry, he joined Yale University for postdoctoral work. Since 2002 he has held the chair for Physical Chemistry at the Friedrich-Schiller University, Jena. Furthermore, since 2006, he is the Scientific Director of the Leibniz Institute of Photonic Technology, Jena. His research interests are mainly concerned with biophotonics according to the needs of pathology, oncology, and infection/sepsis. He is a member and fellow of SAS and SPIE.


Valery P. Zakharov is a Professor and Chair of the Laser and Biotechnical Systems Department, and Head of the Photonics Laboratory, at Samara National Research University. His research interests include: laser medicine, biophotonics, multimodal biomedical imaging, and application of fluorescence and Raman-techniques for biomedical diagnostics. He has been awarded Honored Science Worker of Russia and the Samara Award for Biophotonics innovations. He has published more than 350 publications in peer refereed journals.

Bibliographic Information

Buy it now

Buying options

eBook USD 129.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book USD 169.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book USD 169.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Other ways to access