Radiotherapy in Managing Brain Metastases

1. Front Matter

   Pages i-xv

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2. Introduction

   • Eric Chang, John B. Fiveash, Jonathan Knisely, Yoshiya Yamada

   Pages 1-4

3. Clinical Overview: Brain Metastases

   1. Front Matter

      Pages 5-5

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   2. Brain Metastases: Introduction

      • Mihir Naik, Joycelin F. Canavan, Samuel T. Chao

      Pages 7-19

   3. Radiobiology of Stereotactic Radiosurgery

      • Anuradha Thiagarajan, Yoshiya Yamada

      Pages 21-30

   4. Supportive Medical Management of Brain Metastases Patients Including Treatment Complications

      • Peter C. Pan, Laura E. Donovan, Rajiv S. Magge

      Pages 31-51

   5. Neuroimaging of Brain Metastases

      • Mira A. Patel, Eric Lis, Yoshiya Yamada

      Pages 53-64

   6. The Evolution of Combination Therapies Involving Surgery and Radiosurgery

      • David Peters, Roshan Prabhu, Stuart Burri, Anthony Asher

      Pages 65-83

   7. Laser Interstitial Thermal Therapy for Brain Metastasis

      • Ahmet F. Atik, Krishna C. Joshi, Alireza Mohammad Mohammadi, Gene H. Barnett

      Pages 85-94

   8. Integrating Systemic Therapy into the Management of Brain Metastases

      • John B. Fiveash, Anatoly Nikolaev, Robert M. Conry

      Pages 95-108

   9. Indications for Stereotactic Radiosurgery: Multiple Brain Metastases

      • Anurag Saraf, Tony J. C. Wang

      Pages 109-125

   10. Hypofractionated Stereotactic Radiosurgery for Intact and Resected Brain Metastases

       • Erqi L. Pollom, Siyu Shi, Scott G. Soltys

       Pages 127-141

   11. Target Delineation for Radiosurgery (Including Postoperative Cavity Radiosurgery) in Brain Metastases

       • Balamurugan A. Vellayappan, Mei Chin Lim, Clement Yong, Kejia Teo, Shawn Malone, Simon Lo

       Pages 143-164

   12. Indications for Whole-Brain Radiation Therapy

       • Michael Huo, Fabio Ynoe de Moraes, Matthew Foote, Mark B. Pinkham, Gustavo N. Marta, John H. Suh

       Pages 165-184

   13. Particle Therapy for the Treatment of Brain Metastases

       • Jeremy Brownstein, Hooney D. Min, Marc Bussiere, Helen A. Shih

       Pages 185-196

   14. Special Topics in Brain Metastases Management

       • James Byrne, Kevin S. Oh, Nancy Wang

       Pages 197-215

   15. Salvage/Reirradiation/Retreatment

       • David Roberge

       Pages 217-227

4. Technical: Treatment Planning and Delivery

   1. Front Matter

      Pages 229-229

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   2. General Techniques for Radiosurgery

      • Mark Ruschin, Arjun Sahgal, Lijun Ma, Lei Wang, Ermias Gete, Alan Nichol

      Pages 231-247

   3. Single-Isocenter, Multiple Metastasis Treatment Planning

      • Evan M. Thomas, Richard A. Popple, Elizabeth Covington, John B. Fiveash

      Pages 249-280

This book provides a radiotherapy perspective on the management of brain metastases with case-based discussion. This management has been rapidly evolving in the face of changing technology, progressing systemic therapy, and paradigm changes that all impact practice. These changes can be difficult, and this text gives a practical approach to help practitioners and trainees understand these changes and incorporate them into their practices.

The work has two main sections: Clinical and Technical. The clinical section has chapters that address all aspects of radiation therapy for brain metastases, including integrating advances in surgery and drug treatments. The technical section focuses on the “how to” aspects of treatment, including treatment planning and delivery. 


This is an ideal guide for practicing radiation oncologists and trainees. 

• brain metastases
• radiation therapy
• radiosurgery
• neurologic complications
• central nervous system cancer
• Radiaton Oncology

• Department of Radiation Oncology, Memorial Sloan Kettering Cancer Center, New York, USA

  Yoshiya Yamada

• Department of Radiation Oncology, University of Southern California, Los Angeles, USA

  Eric Chang

• Department of Radiation Oncology, University of Alabama at Birmingham, Birmingham, USA

  John B. Fiveash

• Weill Cornell Medicine, NewYork–Presbyterian Hospital, New York, USA

  Jonathan Knisely

Yoshiya Yamada MD FRCPC is Attending Radiation Oncologist in the Department of Radiation Oncology at Memorial Sloan Kettering Cancer Center.

Eric Chang MD, FASTRO is Professor and Chair in the Department of Radiation Oncology at Keck School of Medicine, University of Southern California. Dr. Chang is also volume editor of the forthcoming Adult CNS Radiation Oncology.


John Fiveash MD is Professor and Vice Chair of the Department of Radiation Oncology at the University of Alabama Birmingham.


Jonathan Knisely MD is in the Department of Radiation Oncology at Weill Cornell Medical Center. 

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