Osteogenesis Imperfecta

1. Front Matter

   Pages i-xv

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2. General Considerations in Treating OI for the Surgeon

   1. Front Matter

      Pages 1-1

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   2. Introduction to Osteogenesis Imperfecta

      • Peter H. Byers, Cecilie Fremstad Rustad

      Pages 3-9

   3. Patient Evaluation and Medical Treatment for Osteogenesis Imperfecta

      • Cristina McGreal, Michael B. Bober

      Pages 11-19

   4. Therapy, Orthotics and Assistive Devices for Osteogenesis Imperfecta

      • Maureen Donohoe

      Pages 21-37

   5. The Structure and Functioning of the Multidisciplinary Clinic in Managing and Monitoring Patients with Osteogenesis Imperfecta in the UK

      • Caroline Elizabeth Ann Marr, Ali Seasman

      Pages 39-55

   6. Quality of Life and Functional Evaluation Measures for Osteogenesis Imperfecta

      • Verity Pacey, Kathleen Montpetit

      Pages 57-70

3. Surgical Planning and Surgery

   1. Front Matter

      Pages 71-71

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   2. Personal Reflections on Care for Osteogenesis Imperfecta

      • François Fassier

      Pages 73-77

   3. Surgical Principles in Treating Osteogenesis Imperfecta

      • Richard W. Kruse, Jeanne M. Franzone

      Pages 79-109

   4. Anesthetic and Post-operative Pain Management

      • Jessica K. Goeller, Leelach Rothschild

      Pages 111-125

4. Surgical Cases: Hip and Extremities

   1. Front Matter

      Pages 127-127

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   2. Morphologic Features and Treatment of the Hip and Proximal Femur in OI

      • Miguel Galban, Carlos Pargas, Adolfredo Santana

      Pages 129-146

   3. Osteogenesis Imperfecta Surgical Management of the Femur and Knee

      • Paul Esposito, Maegen J. Wallace

      Pages 147-182

   4. Osteogenesis Imperfecta in the Tibia and Ankle

      • Darko Antičević

      Pages 183-202

   5. Upper Extremity

      • Thomas Wirth

      Pages 203-220

   6. Osteogenesis Imperfecta in the Spine

      • Suken A. Shah, Maegen J. Wallace

      Pages 221-230

   7. Unique Considerations of the Adult with Osteogenesis Imperfecta

      • Guus J. M. Janus, Anton A. M. Franken, Arjan G. J. Harsevoort, Anne Marieke V. Dommisse

      Pages 231-255

   8. Extremity Surgery in Adults with Osteogenesis Imperfecta

      • Tae-Joon Cho

      Pages 257-264

   9. Management of Osteogenesis Imperfecta in India

      • Hitesh Shah, Benjamin Joseph

      Pages 265-285

Osteogenesis imperfecta (OI), also known as brittle bone disease, is a genetic disease involving primarily the skeleton but affecting all organ systems. It is an extremely multifarious condition causing frequent fractures and limb and spinal deformity, which can often be severe. While there are described surgical procedures to treat these patients, due to the variety of the deformities and the fragility of the bone, the orthopaedic surgeon is often forced to adapt or modify a plan during an operation to achieve success. Surgical experience with the disease worldwide is often limited and variable, and due to constraints on medical equipment and surgical implants in resource-constrained countries, alternate methods of achieving the similar surgical endpoints are possible. 


This book will help guide decision-making in surgery using biologic and surgical principles to assist the planning and execution of surgery with available resources. It will then provide the surgeon with background knowledge of the genetic, medical and surgical principles necessary to formulate a comprehensive treatment plan, illustrated by varied and complex patient cases from experienced surgeons and clinicians worldwide. Beginning with an introduction to osteogenesis imperfecta and the general care of the patient, the book is divided into thematic sections covering general surgical considerations, principles of extremity surgery, and surgical cases on the pelvis, upper and lower extremities, and the spine, it will incorporate aspects of surgical decision-making, including cultural and geographic factors, to give a truly global perspective on the care of these complex patients.

• Bisphosphonates
• Bone grafting
• Bracing
• Brittle bone disease
• Compression plates
• Congenital deformity
• External fixation
• Kyphoscoliosis
• Limb alignment
• Locked plates
• Multidisciplinary care
• Orthotics
• Osteoconduction
• Osteogenesis
• Osteogenesis imperfecta (OI)
• Osteotomy
• Physical therapy
• Rodding surgery
• Scoliosis
• Stabilizing surgery

• Department of Orthopaedic Surgery, Nemours/Alfred I. Dupont Hospital for Children, Wilmington, USA

  Richard W. Kruse

Richard W. Kruse, DO, MBA, FAAOS, FAAP, FAOA, Clinical Professor, Department of orthopaedic Surgery, Nemours/Alfred I. DuPont Hospital for Children, Wilmington, DE, USA

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