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  • © 2020

Xenobiotic Metabolic Enzymes: Bioactivation and Antioxidant Defense

Authors:

  • Comprehensive overview of xenobiotic enzymes and their health implications
  • Foreign compounds discussed include drugs, foods, smoke, and other chemicals
  • Can serve as a resource for researchers and supplemental text for students in biochemistry, biomedical science, pharmacology, and environmental sciences

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Table of contents (20 chapters)

  1. Front Matter

    Pages i-xvii
  2. Overview

    • Chang-Hwei Chen
    Pages 1-9
  3. Metabolisms of Foreign Compounds

    • Chang-Hwei Chen
    Pages 35-44
  4. Bioactivation Metabolism: Activation Enzymes

    • Chang-Hwei Chen
    Pages 45-58
  5. Diversity of Metabolic Enzyme Modulators

    • Chang-Hwei Chen
    Pages 205-219
  6. Dietary Inducers of Detoxification Enzymes

    • Chang-Hwei Chen
    Pages 221-234

About this book

This book provides a comprehensive, organized, and concise overview of xenobiotic metabolic enzymes and their health implications. The subjects addressed are broad in scope with an emphasis on recent advances in research on biochemical and biomedical aspects of these enzymes. The xenobiotics discussed include not just drugs, but also food, smoke, and other environmental chemicals. 


The subjects covered in this work include: metabolic enzymes and their catalyzed reactions, reactive intermediates generated from metabolic activation, oxidative stress mediated by electrophilic reactive intermediates, bioactivation - mediated cellular and functional damages, activation of Nrf2 – ARE pathway, genetic variations affecting metabolic enzyme expression, enzyme polymorphisms affecting xenobiotic - mediated toxicity, induction of metabolic enzymes for health benefits, and a diversity of metabolic enzyme modulators.


Authors and Affiliations

  • Institute for Health and the Environment and Department of Biomedical Sciences, University at Albany, State University of New York, 5 University Place, Rensselaer, USA

    Chang-Hwei Chen

About the author



Dr. Chang-Hwei Chen is a biophysicist and professor emeritus of Biomedical Sciences at the School of Public Heath, University at Albany. He is currently a member of the Institute of Health and the Environment at the University at Albany. 

Bibliographic Information

  • Book Title: Xenobiotic Metabolic Enzymes: Bioactivation and Antioxidant Defense

  • Authors: Chang-Hwei Chen

  • DOI: https://doi.org/10.1007/978-3-030-41679-9

  • Publisher: Springer Cham

  • eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)

  • Copyright Information: Springer Nature Switzerland AG 2020

  • Hardcover ISBN: 978-3-030-41678-2Published: 04 April 2020

  • Softcover ISBN: 978-3-030-41681-2Published: 04 April 2021

  • eBook ISBN: 978-3-030-41679-9Published: 03 April 2020

  • Edition Number: 1

  • Number of Pages: XVII, 239

  • Number of Illustrations: 50 b/w illustrations, 3 illustrations in colour

  • Topics: Human Physiology, Enzymology, Pharmacology/Toxicology

Buy it now

Buying options

eBook USD 129.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book USD 169.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book USD 169.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Other ways to access