Overview
- Provides a timely and extensive overview of current knowledge of cerebral glycogen aimed at fundamentally revisiting the vestigial nature commonly associated with this polysaccharide in the brain
- Focuses on glycogen in the brain and provides detailed information about novel hypotheses on its role
- Explores the role of glycogen in health and disease
Part of the book series: Advances in Neurobiology (NEUROBIOL, volume 23)
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Table of contents (14 chapters)
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Front Matter
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Back Matter
Keywords
About this book
This book aims to provide a state-of-the-art summary of what is currently known about brain glycogen metabolism, detailing the recent advances in our understanding of why glycogen is so critical for normal brain function. The role of glycogen in cellular neurophysiology remains largely unclear and its specific contribution to the energy demand of brain cells is still elusive.Glycogen is the sole cerebral glucose reserve and is emerging as a fundamental component of brain energy metabolism. Pharmacological or genetic manipulation of glycogen metabolism in the brain impairs memory formation and increases susceptibility to epileptic seizures and cortical spreading depression. Glycogen is also directly implicated in abnormal neuronal excitability and mental retardation that characterize brain disorders like Lafora disease and Pompe disease.
Editors and Affiliations
Bibliographic Information
Book Title: Brain Glycogen Metabolism
Editors: Mauro DiNuzzo, Arne Schousboe
Series Title: Advances in Neurobiology
DOI: https://doi.org/10.1007/978-3-030-27480-1
Publisher: Springer Cham
eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)
Copyright Information: Springer Nature Switzerland AG 2019
Hardcover ISBN: 978-3-030-27479-5Published: 20 November 2019
Softcover ISBN: 978-3-030-27482-5Published: 20 November 2020
eBook ISBN: 978-3-030-27480-1Published: 31 October 2019
Series ISSN: 2190-5215
Series E-ISSN: 2190-5223
Edition Number: 1
Number of Pages: VIII, 443
Number of Illustrations: 24 b/w illustrations, 61 illustrations in colour
Topics: Neurosciences