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Metallocofactors that Activate Small Molecules

With Focus on Bioinorganic Chemistry

  • Book
  • © 2019

Overview

Editors:
  1. Markus W. Ribbe

    1. Departments of Molecular Biology & Biochemistry, and Chemistry, University of California, Irvine, USA

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  • Presents an overview of the fundamental chemistry of metallocofactors within the field of bioinorganic chemistry
  • Provides a review of the mechanistic understanding of metallocofactors
  • Multi-authored volume with contributions from world renowned experts in the field

Part of the book series: Structure and Bonding (STRUCTURE, volume 179)

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Table of contents (6 chapters)

  1. Front Matter

    Pages i-vii
    Download chapter PDF

  2. Looking at Nitrogenase: Insights from Modern Structural Approaches

    • Belinda B. Wenke, Thomas Spatzal
    Pages 1-13

  3. Current Understanding of the Biosynthesis of the Unique Nitrogenase Cofactor Core

    • Caleb J. Hiller, Lee A. Rettberg, Chi Chung Lee, Martin T. Stiebritz, Yilin Hu
    Pages 15-31

  4. Recent Advances in the Chemical Synthesis of Nitrogenase Model Clusters

    • Kazuki Tanifuji, Yasuhiro Ohki
    Pages 33-61

  5. The Catalytic Mechanisms of the Molybdenum and Tungsten Enzymes

    • Andrew M. Crawford, Julien J. H. Cotelesage, Roger C. Prince, Graham N. George
    Pages 63-100

  6. The Role of the Pyranopterin Dithiolene Component of Moco in Molybdoenzyme Catalysis

    • Sharon J. Nieter Burgmayer, Martin L. Kirk
    Pages 101-151

  7. Mechanism of Ni,Fe-Containing Carbon Monoxide Dehydrogenases

    • Holger Dobbek
    Pages 153-166

  8. Back Matter

    Pages 167-169
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Keywords

About this book

This volume highlights recent progress on the fundamental chemistry and mechanistic understanding of metallocofactors, with an emphasis on the major development in these areas from the perspective of bioinorganic chemistry. 

Metallocofactors are essential for all forms of life and include a variety of metals, such as iron, molybdenum, vanadium, and nickel. Structurally fascinating metallocofactors featuring these metals are present in many bacteria and mediate remarkable metabolic redox chemistry with small molecule substrates, including N2, CO, H2, and CO2. Current interest in understanding how these metallocofactors function at the atomic level is enormous, especially in the context of sustainably feeding and fueling our planet; if we can understand how these cofactors work, then there is the possibility to design synthetic catalysts that function similarly. 

Editors and Affiliations

  • Departments of Molecular Biology & Biochemistry, and Chemistry, University of California, Irvine, USA

    Markus W. Ribbe

About the editor

The focus of Dr. Ribbe’s research is the assembly and mechanism of nitrogenase, one of the most complex metalloenzymes known to date. Nitrogenase can be appreciated from the perspective of the useful agricultural and industrial products it generates, namely, ammonia, hydrogen and hydrocarbons. Since the beginning of his independent career, Dr. Ribbe has focused his efforts on investigating the biosynthesis of the Mo-nitrogenase from Azotobacter vinelandii and, in particular, the unique metal centers of its MoFe protein component: FeMoco and P-cluster. Results of these studies have firmly established nitrogenase MoFe protein as a model system that could be used to deduce the general mechanism of metal cluster assembly and develop successful strategies for synthesizing bio-inspired catalysts for industrial usage. Recently, Dr. Ribbe expanded his research to the investigation of the structure and function of the “alternative” V-nitrogenase from Azotobacter vinelandii. His discovery that V-nitrogenase can convert CO to hydrocarbons provides a potential blueprint for developing cost-efficient processes for industrial production of biofuels in the future.

Bibliographic Information

  • Book Title: Metallocofactors that Activate Small Molecules

  • Book Subtitle: With Focus on Bioinorganic Chemistry

  • Editors: Markus W. Ribbe

  • Series Title: Structure and Bonding

  • DOI: https://doi.org/10.1007/978-3-030-25897-9

  • Publisher: Springer Cham

  • eBook Packages: Chemistry and Materials Science, Chemistry and Material Science (R0)

  • Copyright Information: Springer Nature Switzerland AG 2019

  • Hardcover ISBN: 978-3-030-25896-2Published: 25 September 2019

  • Softcover ISBN: 978-3-030-25899-3Published: 25 September 2020

  • eBook ISBN: 978-3-030-25897-9Published: 11 September 2019

  • Series ISSN: 0081-5993

  • Series E-ISSN: 1616-8550

  • Edition Number: 1

  • Number of Pages: VII, 169

  • Number of Illustrations: 9 b/w illustrations, 61 illustrations in colour

  • Topics: Inorganic Chemistry, Catalysis, Enzymology, Biotechnology, Protein Structure

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