Recent Advances in Cannabinoid Physiology and Pathology

1. Front Matter

   Pages i-ix

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2. Endocannabinoid System Components: Overview and Tissue Distribution

   • Neal Joshi, Emmanuel S. Onaivi

   Pages 1-12

3. Physiology of the Endocannabinoid System During Development

   • Anna N. Bukiya

   Pages 13-37

4. Cannabinoid Interactions with Proteins: Insights from Structural Studies

   • Anna N. Bukiya, Alex M. Dopico

   Pages 39-50

5. Cannabinoid Signaling in Cancer

   • Subhadip Das, Kirti Kaul, Sanjay Mishra, Manish Charan, Ramesh K. Ganju

   Pages 51-61

6. Cannabinoids and Cardiovascular System

   • Alexander I. Bondarenko

   Pages 63-87

7. Endocannabinoid System and Alcohol Abuse Disorders

   • Balapal S. Basavarajappa

   Pages 89-127

8. Genetic Factors in Cannabinoid Use and Dependence

   • Megan K. Mulligan

   Pages 129-150

9. Pharmacology of Medical Cannabis

   • Md Ruhul Amin, Declan W. Ali

   Pages 151-165

10. Back Matter

    Pages 167-167

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The cannabinoid system plays a central role in a wide variety of physiological functions that touch upon cardiovascular, gastrointestinal, immune, and nervous systems. Cannabinoids also play a central role in developmental physiology, management of pain, and shaping of human behaviour. Recent movements towards legalization of marijuana use have bolstered scientific interest in the cannabinoid field and led to research efforts that would unveil multi-faceted effects and mechanisms of cannabinoid presence in different organs and at various stages of development. This book summarizes the recent advances in the field of cannabinoid research at multiple levels of resolution. It spans from systemic effects of cannabinoids on development, physiological function, and prevalent pathophysiological conditions to mechanisms that govern cannabinoid interaction with their relevant protein targets at atomic resolution. This book will be of interest to a specialized audience in the fields of biochemistry, pharmacology and developmental biology but alsoto a wider readership with interest in general physiology and cannabinoid signalling in biological systems. 

• cannabinoid signalling
• medical cannabinoid usage
• endocannabinoid system
• protein targets
• cannabinoids in cancer

• Department of Pharmacology, College of Medicine, The University of Tennessee Health Science Center, Memphis, USA

  Anna N. Bukiya

Dr. Anna N. Bukiya, Ph.D., is an Associate Professor at the Department of Pharmacology, College of Medicine, The University of Tennessee Health Science Center. Her scientific interests lie in the field of lipid modulation of ionic currents and cerebral artery sensitivity to drugs of abuse starting from in utero development and spanning into the adulthood. These studies employ an array of computational, biochemical, electrophysiological, and integrative approaches. Dr. Anna Bukiya is a member of Biophysical Society, American Society for Pharmacology and Experimental Therapeutics, Research Society on Alcoholism, and International Drug Abuse Research Society.

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