Editors:
- Very timely topic as cholesterol, increasingly, has been implicated as a major regulator of protein function
- Contributors are well-known experts in their fields and provide international perspective
- Research will be invaluable across several areas from biochemistry to nutrition
Part of the book series: Advances in Experimental Medicine and Biology (AEMB, volume 1135)
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Table of contents (8 chapters)
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Front Matter
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General Characteristics of Cholesterol Binding Sites
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Front Matter
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Cholesterol Binding Sites in Proteins: Case Studies
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Front Matter
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Back Matter
About this book
In this book, renowned scientists describe how cholesterol interacts with various proteins. Recent progress made in the high-resolution visualization of cholesterol-protein interactions using crystallography and cryogenic electron microscopy has substantially advanced the knowledge of critical features. These features enable specific recognition of the cholesterol molecule by proteins, a process that was built on earlier studies using binding assays, computational modeling and site-directed mutagenesis.
Direct Mechanisms in Cholesterol Modulation of Protein Function offers comprehensive insights into the current understanding of cholesterol-driven modulation of protein function via direct sensing. Its nine chapters are organized into two distinct parts. In the first part, the chapters introduce the reader to the general characteristics of cholesterol binding sites in proteins. This part starts with a tour into common cholesterol recognition motifs, followed by an overview of the major classes of steroid-binding proteins. It then continues with two chapters that present a comprehensive analysis of molecular and structural characteristics of cholesterol binding sites in transmembrane and soluble protein domains. In the second part of the book, examples of cholesterol binding sites and consequences of specific cholesterol recognition for protein function are presented for G protein-coupled receptors, ion channels and cholesterol-transporting proteins.
The book is valuable for undergraduate and graduate students in biochemistry and nutrition, as well as basic science and medical researchers with a keen interest in the biophysical properties of cholesterol and physiological consequences of cholesterol presence in biological systems.
Editors and Affiliations
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Department of Chemistry, University of Illinois, Chicago, USA
Avia Rosenhouse-Dantsker
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Department of Pharmacology, The University of Tennessee HSC, Memphis, USA
Anna N. Bukiya
Bibliographic Information
Book Title: Direct Mechanisms in Cholesterol Modulation of Protein Function
Editors: Avia Rosenhouse-Dantsker, Anna N. Bukiya
Series Title: Advances in Experimental Medicine and Biology
DOI: https://doi.org/10.1007/978-3-030-14265-0
Publisher: Springer Cham
eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)
Copyright Information: The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Nature Switzerland AG 2019
Hardcover ISBN: 978-3-030-14264-3Published: 27 May 2019
Softcover ISBN: 978-3-030-14267-4Published: 14 August 2020
eBook ISBN: 978-3-030-14265-0Published: 16 May 2019
Series ISSN: 0065-2598
Series E-ISSN: 2214-8019
Edition Number: 1
Number of Pages: IX, 168
Number of Illustrations: 1 b/w illustrations, 50 illustrations in colour
Topics: Proteomics, Protein Science, Membrane Biology, Molecular Medicine