Biomimetic Lipid Membranes: Fundamentals, Applications, and Commercialization

1. Front Matter

   Pages i-xxix

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2. Structural and Mechanical Characterization of Supported Model Membranes by AFM

   • Berta Gumí-Audenis, Marina I. Giannotti

   Pages 1-27

3. To Image the Orientation and Spatial Distribution of Reconstituted Na+,K+-ATPase in Model Lipid Membranes

   • Tripta Bhatia, Flemming Cornelius

   Pages 29-46

4. Asymmetric Model Membranes: Frontiers and Challenges

   • Michael H. L. Nguyen, Brett W. Rickeard, Mitchell DiPasquale, Drew Marquardt

   Pages 47-71

5. Modeling of Cell Membrane Systems

   • Tuğba Arzu Özal İldeniz

   Pages 73-108

6. Molecular Dynamics Studies of Nanoparticle Transport Through Model Lipid Membranes

   • Cynthia J. Jameson, Priyanka Oroskar, Bo Song, Huajun Yuan, Sohail Murad

   Pages 109-165

7. Investigation of Cell Interactions on Biomimetic Lipid Membranes

   • Abdulhalim Kılıç, Fatma Neşe Kök

   Pages 167-181

8. Tethered Lipid Membranes as Platforms for Biophysical Studies and Advanced Biosensors

   • Jakob Andersson, Wolfgang Knoll

   Pages 183-191

9. Biomedical Applications: Liposomes and Supported Lipid Bilayers for Diagnostics, Theranostics, Imaging, Vaccine Formulation, and Tissue Engineering

   • M. Özgen Öztürk Öncel, Bora Garipcan, Fatih Inci

   Pages 193-212

10. Lipid Bilayers and Liposomes on Microfluidics Realm: Techniques and Applications

    • Fatih Inci

    Pages 213-223

11. Biomimetic Model Membranes as Drug Screening Platform

    • Rumeysa Bilginer, Ahu Arslan Yildiz

    Pages 225-247

12. Biomimetic Membranes as an Emerging Water Filtration Technology

    • Reyhan Sengur-Tasdemir, Havva Esra Tutuncu, Nevin Gul-Karaguler, Esra Ates-Genceli, Ismail Koyuncu

    Pages 249-283

13. Applications of Lipid Membranes-based Biosensors for the Rapid Detection of Food Toxicants and Environmental Pollutants

    • Georgia-Paraskevi Nikoleli, Dimitrios P. Nikolelis, Christina G. Siontorou, Marianna-Thalia Nikolelis, Stephanos Karapetis

    Pages 285-297

14. Back Matter

    Pages 299-306

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This book compiles the fundamentals, applications and viable product strategies of biomimetic lipid membranes into a single, comprehensive source. It broadens its perspective to interdisciplinary realms incorporating medicine, biology, physics, chemistry, materials science, as well as engineering and pharmacy at large. The book guides readers from membrane structure and models to biophysical chemistry and functionalization of membrane surfaces. It then takes the reader through a myriad of surface-sensitive techniques before delving into cutting-edge applications that could help inspire new research directions. With more than half the world's drugs and various toxins targeting these crucial structures, the book addresses a topic of major importance in the field of medicine, particularly biosensor design, diagnostic tool development, vaccine formulation, micro/nano-array systems, and drug screening/development.

• Provides fundamental knowledge on biomimetic lipid membranes;
• Addresses some of biomimetic membrane types, preparation methods, properties and characterization techniques;
• Explains state-of-art technological developments that incorporate microfluidic systems, array technologies, lab-on-a-chip-tools, biosensing, and bioprinting techniques;
• Describes the integration of biomimetic membranes with current top-notch tools and platforms;
• Examines applications in medicine, pharmaceutical industry, and environmental monitoring.
  

• Biomimetic Models
• Lipid Membranes
• Membrane Biophysics
• Membrane Dynamics
• Surface Chemistry
• Surface sensing techniques
• Microfluidics
• biomimetic membranes for water purification
• Biomedical applications
• Biosensing applications
• Diagnostics
• Biomimetic Membranes for Sensor
• biochemical engineering

• Department of Molecular Biology and Genetics, İstanbul Technical University, Istanbul, Turkey

  Fatma N. Kök

• Department of Bioengineering, Izmir Institute of Technology, Urla, Turkey

  Ahu Arslan Yildiz

• School of Medicine, Stanford University, Palo Alto, USA

  Fatih Inci

Dr. Fatma Neşe KÖK is currently Associated Professor in the Molecular Biology and Genetics Department of Istanbul Technical University, Turkey. She graduated from the Chemical Engineering Department at the Middle East Technical University and received her M.Sc. and Ph.D degrees from Biotechnology Program at the same University in 1997 and 2001, respectively. After receiving a postdoctoral research fellowship from the Alexander von Humboldt Foundation, she spent 2.5 years in Germany, in a joint project of Max Planck Institute (MPI) for Polymer Research (Mainz) and MPI for Biochemistry (Martinstred) (2002-2005) working on artificial lipid membranes. Her research interests include biomaterials and tissue engineering scaffold design, biosensors, controlled release systems, and construction and characterization of artificial lipid bilayers. 

Dr. Ahu Arslan Yildiz is currently Assistant Professor in the Bioengineering Department at the Izmir Institute of Technology (IZTECH). Previously, she was an Assistant Professor at Okan University's Genetics and Bioengineering Department and a visiting fellow at the Canary Center for Cancer Early Detection, Department of Radiology, Stanford University School of Medicine. She received her BSc degree in Chemistry in 2003 from Hacettepe University and the MSc degree in 2006 in Chemistry from Middle East Technical University. She received her Ph.D. in Biology in 2010 from the Max-Planck Institute Polymer Research and Johannes Gutenberg University. She specializes in the field of artificial cell membrane and membrane receptor research. Her research interests include applications of biotechnology, including biomimetic systems, biomaterials, tissue engineering and regenerative medicine, 3D cell culture, diagnostic tools, drug screening and lab-on-a-chip microfluidic devices.

Dr. Fatih Inci is currently working as a Research Scientist (Faculty/Academic Staff) at Stanford University School of Medicine, Canary Center at Stanford for Cancer Early Detection. Dr. Inci received his PhD degree from Istanbul Technical University (Turkey), focusing on artificial lipid membranes and their clinical and pharmaceutical applications on surface-sensitive platforms. During his Ph.D. studies, he was also appointed as a visiting scientist at the University of New South Wales (Sydney, Australia) and University of Technology Sydney (Australia). He also worked as a research scholar at Brigham and Women’s Hospital (BWH)-Harvard Medical School, and Harvard-MIT Health Sciences and Technology Division (Boston, MA, United States). Dr. Inci was then appointed a Postdoctoral Research Fellow at BWH-Harvard Medical School and Stanford University School of Medicine (Palo Alto, CA, United States) in 2013 and 2014, respectively. Dr. Inci’s area of excellence in research is to create micro- and nano-scale platform technologies in the fields of biomedical engineering, biotechnology and medicine by manipulating biomolecules, cells, and viruses in micro and nano-scale entities. His platform offers precise solutions for real-world challenges in clinical diagnostics, personalized medicine, cancer early detection, forensic science, and biomarker discovery. His research interests also focus on many applications of microfluidics, biosensors, nanoplasmonics, lab-on-a-chip, artificial lipid membranes, disease on-chip models, and drug delivery systems.

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