Membrane Dynamics and Calcium Signaling

1. Front Matter

   Pages i-viii

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2. Plasma Membrane

   1. Front Matter

      Pages 1-1

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   2. The Plasma Membrane Calcium Pump (PMCA): Regulation of Cytosolic Ca2+, Genetic Diversities and Its Role in Sub-plasma Membrane Microdomains

      • Joachim Krebs

      Pages 3-21

   3. Structure-Function Relationship of the Voltage-Gated Calcium Channel Cav1.1 Complex

      • Jianping Wu, Nieng Yan, Zhen Yan

      Pages 23-39

   4. Structure-Dynamic Coupling Through Ca2+-Binding Regulatory Domains of Mammalian NCX Isoform/Splice Variants

      • Daniel Khananshvili

      Pages 41-58

3. Endoplasmic/Sarcoplasmic Reticulum

   1. Front Matter

      Pages 59-59

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   2. The Endoplasmic Reticulum and the Cellular Reticular Network

      • Luis B. Agellon, Marek Michalak

      Pages 61-76

   3. Structure-Function Relationship of the SERCA Pump and Its Regulation by Phospholamban and Sarcolipin

      • Przemek A. Gorski, Delaine K. Ceholski, Howard S. Young

      Pages 77-119

   4. Structural Insights into IP3R Function

      • Irina I. Serysheva, Mariah R. Baker, Guizhen Fan

      Pages 121-147

   5. IP3 Receptor Properties and Function at Membrane Contact Sites

      • Gemma Roest, Rita M. La Rovere, Geert Bultynck, Jan B. Parys

      Pages 149-178

   6. Structural Details of the Ryanodine Receptor Calcium Release Channel and Its Gating Mechanism

      • Katrien Willegems, Rouslan G. Efremov

      Pages 179-204

   7. Store-Operated Calcium Entry: An Historical Overview

      • James W. Putney

      Pages 205-214

   8. From Stores to Sinks: Structural Mechanisms of Cytosolic Calcium Regulation

      • Masahiro Enomoto, Tadateru Nishikawa, Naveed Siddiqui, Steve Chung, Mitsuhiko Ikura, Peter B. Stathopulos

      Pages 215-251

   9. Assembly of ER-PM Junctions: A Critical Determinant in the Regulation of SOCE and TRPC1

      • Krishna P. Subedi, Hwei Ling Ong, Indu S. Ambudkar

      Pages 253-276

4. Mitochondria

   1. Front Matter

      Pages 277-277

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   2. Beyond Intracellular Signaling: The Ins and Outs of Second Messengers Microdomains

      • Riccardo Filadi, Emy Basso, Konstantinos Lefkimmiatis, Tullio Pozzan

      Pages 279-322

   3. Mitochondrial VDAC, the Na+/Ca2+ Exchanger, and the Ca2+ Uniporter in Ca2+ Dynamics and Signaling

      • Varda Shoshan-Barmatz, Soumasree De

      Pages 323-347

5. Annexins

   1. Front Matter

      Pages 349-349

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   2. Annexins: Ca2+ Effectors Determining Membrane Trafficking in the Late Endocytic Compartment

      • Carlos Enrich, Carles Rentero, Elsa Meneses-Salas, Francesc Tebar, Thomas Grewal

      Pages 351-385

6. Cytokinesis and Ca2+ Signaling

   1. Front Matter

      Pages 387-387

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This book describes the newest discoveries on calcium signaling happening at the cellular and intracellular membranes, often exerted in so called microdomains. Calcium entry and release, its interaction with proteins and resulting events on proteins and organelles are comprehensively depicted by leading experts in the field.

Knowledge about details of these highly dynamic processes rapidly increased in recent years, the book therefore provides a timely summary on the processes of calcium signaling and related membrane dynamics; it is aimed at students and researchers in biochemistry and cell biology.

• calcium signaling
• calcium transport
• endoplasmatic reticulum
• membrane dynamics
• membrane contact sites
• microdomains
• mitochondria
• plasma membrane
• Protein-Ligand Interactions

• MPI for Biophysical Chemistry, Göttingen, Germany

  Joachim Krebs

Prof. Joachim Krebs is Prof. Emeritus of the Swiss federal Institute of Technology (ETH) ; at present he is Consultant at the MPI for Biophysical Chemistry, Department on NMR-based Structural Biology, Göttingen, Germany. Prof. Krebs was working for more than 30 years in the field of calcium signaling, calcium-binding and calcium-transport proteins and has importantly contributed to the understanding of calcium function and signaling pathways in the cell.

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