Vitamin E in Human Health

1. Front Matter

   Pages i-xxxix

   PDF

2. Introduction: Why (Another) Book on Vitamin E?

   • Peter Weber, Marc Birringer, Jeffrey B. Blumberg, Manfred Eggersdorfer, Jan Frank

   Pages 1-4

3. Biochemistry, Metabolism and Molecular Effects of Vitamin E

   1. Front Matter

      Pages 5-5

      PDF

   2. History of Vitamin E Research

      • Marc Birringer, Jeffrey B. Blumberg, Manfred Eggersdorfer, Jan Frank, Peter Weber

      Pages 7-18

   3. Antioxidative Activity of Vitamin E

      • Afaf Kamal-Eldin

      Pages 19-30

   4. Bioavailability and Metabolism of Vitamin E

      • Sandra Flory, Marc Birringer, Jan Frank

      Pages 31-41

   5. Occurrence and Bioactivities of Minor Vitamin E Derivatives

      • Marc Birringer, Jan Frank

      Pages 43-60

   6. Bioactivity of Vitamin E Long-Chain Metabolites

      • Stefan Kluge, Martin Schubert, Lisa Schmölz, Maria Wallert, Marc Birringer, Stefan Lorkowski

      Pages 61-79

   7. Gene Regulatory Activity of Vitamin E

      • Alexandra Fischer, Gerald Rimbach

      Pages 81-98

   8. Metabolomic Approaches in Vitamin E Research

      • John K. Lodge

      Pages 99-109

   9. The Tocopherol Transfer Protein: Regulator of Vitamin E Status

      • Jeffrey Atkinson, Varsha Thakur, Danny Manor

      Pages 111-124

   10. The Role of Lipid Rafts in Mediating the Anticancer Effects of γ-Tocotrienol

       • Paul W. Sylvester

       Pages 125-140

   11. Interaction Between Vitamin E and Polyunsaturated Fatty Acids

       • Jean-Marc Zingg, Mohsen Meydani

       Pages 141-159

4. A Global View on Vitamin E Intakes and Status

   1. Front Matter

      Pages 161-161

      PDF

   2. The Challenge of Defining Daily Intake Recommendations: Vitamin E and Polyunsaturated Fatty Acids

      • Daniel Raederstorff, Szabolcs Péter, Peter Weber

      Pages 163-174

   3. Vitamin E Intake and Serum Levels in the General Population: A Global Perspective

      • Szabolcs Péter, Manfred Eggersdorfer, Peter Weber

      Pages 175-188

   4. Vitamin E Intakes and Status in Toddlers, School Kids and Adolescents: What Do We Know?

      • Volker Böhm

      Pages 189-199

   5. Vitamin E Serum Levels and the Challenge to Correct for Lipids: Accounting for the Usual Double Correction for Variance Shared by Total Cholesterol and Fasting Triglycerides Reveals New Insights into the Association with the One-Carbon Pathway

      • Isidor Minović, Camilo G. Sotomayor, Manfred Eggersdorfer, Ineke J. Riphagen, Martin H. de Borst, Louise H. Dekker et al.

      Pages 201-214

   6. Stability of Vitamin E in Foods

      • Marc Pignitter, Silke Grosshagauer, Veronika Somoza

      Pages 215-232

5. Safety of Vitamin E and Interactions with Other Nutrients and Drugs

   1. Front Matter

      Pages 233-233

      PDF

Vitamin E is a well described and established fat-soluble essential micronutrient and as such has to be provided to the human body on a regular basis in order to avoid deficiency and maintain a healthy status. This is well established and also reviewed in a number of publications. However, a huge body of evidence has accumulated over the last decade, or so, which provides new insights on the mode of action of vitamin E, and the biological role of the tocopherol isomers, and sheds new light on the role of vitamin E in human health. Both fundamental knowledge gain and new data on the role and challenges of vitamin E as an essential micronutrient, including emerging evidence on clinical benefits, will be addressed to put this essential micronutrient in the appropriate perspective.  


Given this level of new evidence which has emerged over the recent years, a book on vitamin E will put into per

spective the concerns which have been raised on vitamin E and which resulted in a misinformation and confusion of the public regarding the importance of vitamin E for human health. This book will reemphasize that Vitamin E is clearly required for human health and its inadequacy leads to increased risk of a variety of diseases. In addition new data of non-communicable diseases (NCD) dependent on vitamin E status show that a lifetime of low intake increases risks of development, severity and complications of NCDs. This text will put the vitamin E case into an up-to-date, science based, applicable real-life perspective and offer pragmatic solutions for its safe and personalized use beyond the various methodological and statistical controversies. The purpose of this book is also to raise awareness not only in the nutrition and medical community, but also in the public media that there are a number of health conditions where an increased intake of vitamin E can be of potential importance. Further this review shouldalso stimulate funding organizations and agencies to increase their support for vitamin E research in order to facilitate the further exploration of the safe and efficacious use of this essential micronutrient.

• Vitamin E and Hormones
• Vitamin E in Fetal Development
• Vitamin E in the Brain
• Apha-tocopherol Transfer Protein
• Vitamin E and Drug Interactions
• Vitamin E and Pregnancy
• Vitamin E and Obesity
• Vitamin E and Insulin Sensitivity

• University of Hohenheim, Institute of Nutritional Sciences, Stuttgart , Germany

  Peter Weber, Jan Frank

• University of Applied Sciences Fulda, Nutritional, Food and Consumer Sciences, Fulda, Germany

  Marc Birringer

• Friedman School of Nutrition Science and Policy, Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, USA

  Jeffrey B. Blumberg

• University Medical Center Groningen, Hanzeplain 1, Groningen, The Netherlands

  Manfred Eggersdorfer

Peter Weber
Institute of Biological Chemistry and Nutrition
University of Hohenheim
Stuttgart, Germany



Marc Birringer
Department of Nutritional, Food and Consumer Sciences
Fulda University of Applied Sciences
Fulda, Germany



Jeffrey B. Blumberg,PhD, 
Jean Mayer USDA Human Nutrition Research Center on Aging
Friedman School of Nutrition Science and Policy
Tufts University


Manfred Eggersdorfer 
DSM Nutritional Products
Kaiseraugst, Switzerland



Jan Frank
Institute of Biological Chemistry and Nutrition
University of Hohenheim
Stuttgart, Germany

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