Corneal Regeneration

1. Front Matter

   Pages i-xxv

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2. Corneal Regeneration: The Concept, the Facts, the Potential

   1. Front Matter

      Pages 1-1

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   2. Corneal Anatomy

      • Miguel Gonzalez-Andrades, Pablo Argüeso, Ilene Gipson

      Pages 3-12

   3. Corneal Healing

      • Veronica Vargas, Francisco Arnalich-Montiel, Jorge L. Alió del Barrio

      Pages 13-22

   4. Corneal Tissue Engineering

      • Mohammad Mirazul Islam, Roholah Sharifi, Miguel Gonzalez-Andrades

      Pages 23-37

3. The Stem Cell

   1. Front Matter

      Pages 39-39

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   2. Stem Cells: Concept, Properties, and Characterization

      • Natalia Escacena-Acosta, Javier Lopez-Beas, Christian Claude Lachaud, Mehrdad Vakilian, Juan Rigoberto Tejedo, Vivian Capilla-González et al.

      Pages 41-55

   3. Corneal Stem Cells: Identification and Methods of Ex Vivo Expansion

      • Christian Claude Lachaud, Abdelkrim Hmadcha, Bernat Soria

      Pages 57-75

   4. Corneal Epithelial Stem Cells: Methods for Ex Vivo Expansion

      • Gustavo S. Figueiredo, Hardeep Singh Mudhar, Majlinda Lako, Francisco C. Figueiredo

      Pages 77-97

   5. Corneal Stromal Stem Cell: Methods for Ex Vivo Expansion

      • Olena Al-Shymali, Jorge L. Alió del Barrio, James L. Funderburgh

      Pages 99-108

   6. Corneal Endothelial Cells: Methods for Ex Vivo Expansion

      • Stephen Wahlig, Matthew Lovatt, Gary Swee-Lim Peh, Jodhbir S. Mehta

      Pages 109-122

   7. Corneal Regeneration: Use of Extracorneal Stem Cells

      • Christian Claude Lachaud, Abdelkrim Hmadcha, Bernat Soria

      Pages 123-144

   8. One Cell, Two Phenotypes: Capturing Pluripotency for Corneal Regeneration

      • Trevor Sherwin, Carol Ann Greene, Colin R. Green, Kushant R. Kapadia

      Pages 145-154

   9. Corneal Stem Cell-Based Therapies

      • Yuzuru Sasamoto, Yoshinori Oie, Kohji Nishida

      Pages 155-172

4. Regenerative Surgery and Therapy of the Ocular Surface Epithelium

   1. Front Matter

      Pages 173-173

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   2. Ocular Surface Epithelium: Applied Anatomy

      • Harminder Singh Dua, Dalia G. Said

      Pages 175-190

   3. Classical Techniques for Limbal Transplantation

      • Rafael I. Barraquer, Juan Alvarez de Toledo

      Pages 191-211

   4. Simple Limbal Epithelial Transplantation: An Update

      • Nandini Venkateswaran, Guillermo Amescua

      Pages 213-219

   5. Cell Therapy Using Ex Vivo Cultured Limbal Cells: CLET and Equivalent

      • Paolo Rama, Giulio Ferrari

      Pages 221-224

   6. Cell Therapy Using Cultivated Oral Mucosal Epithelial Transplant (COMET)

      • Roberto Fernández Buenaga, Sajjad Ahmad

      Pages 225-230

This text provides expert instruction on the varying surgical techniques currently employed for the regeneration of the ocular surface. Corneal Regeneration: Therapy and Surgery begins with a thorough discussion of current research based on data obtained in clinical human studies, and discusses the potential clinical implications for this promising new stage of eye surgery. Sections devoted to the stem cell, regenerative surgery and therapy of the ocular surface epithelium, corneal stroma, and corneal endothelium follow, each section comprehensively covering  applied anatomy, current therapy and regenerative techniques, with a look to future directions of the field including eventual cell therapy.

Corneal Regeneration: Therapy and Surgery is the first book of its kind, systematically covering the developments the medical community has achieved in corneal regeneration from all angles. Written and edited by leading experts in the field, researchers and ophthalmologists alike will find this to be a unique source of information on corneal regeneration, as well as a thoughtful reflection on potential applications of regenerative surgery in ophthalmology as a whole.

 

• cornea
• corneal surgery
• corneal regeneration
• corneal blindness
• corneal therapy

• Miguel Hernández University , Alicante, Spain

  Jorge L. Alió

• Vissum-Instituto Oftalmologico de Alica, University Miguel Hernandez, Alicante, Spain

  Jorge L. Alió del Barrio

• Vissum Corporation, Madrid, Spain

  Francisco Arnalich-Montiel

Prof. Dr Jorge Alió has been Professor and Chairman of Ophthalmology since 1987, first at the University of Alicante and since 2002 at the University Miguel Hernandez de Elche, also in Alicante, Spain. Dr. Alió has been deeply involved since the beginning of his professional career in Academic and Research activities in combination with an intense clinical and surgical practice. His main dedication has been to Cataract, Cornea and Refractive Surgery, even though within the broad basis of his medical education he has been involved in other areas such as Ocular Inflammation (uveitis), Vitreoretinal diseases and Strabismus surgery.  The activities of Dr. Alió are currently mainly oriented on an international basis and he has contributed to the organization, funding and dissemination of different international and Spanish scientific societies. He has collaborated in the organization of many international and Spanish symposiums and congresses, such as the International Ocular Inflammation Society ( IOIS ) the European Society of Cataract and Refractive Surgery ( ESCRS ), The American Academy of Ophthalmology (AAO) the International Society of Refractive Surgery ( ISRS) and the World Ophthalmology Congress ( WOC ) among many others. He has been the author or co-author of 440 peer review papers published in prestigious international scientific journals, 241 book chapters, 78 books (as editor or co-editor), over 200 collaborations in ophthalmic scientific journals and over 1800 presentations and invited lectures in international meetings. 

Policies and ethics