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Insulin Resistance

Childhood Precursors and Adult Disease

  • Book
  • © 2008

Overview

Editors:
  1. Philip Scott Zeitler

    1. Department of Pediatrics, University of Colorado Denver, Aurora, USA

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    You can also search for this editor in PubMed   Google Scholar

  2. Kristen J. Nadeau

    1. Department of Pediatrics, University of Colorado Denver, Aurora, USA

    View editor publications

    You can also search for this editor in PubMed   Google Scholar

  • State-of-the-art perspective on insulin resistance by renowned experts in the field
  • Topics cover insulin resistance and its consequences across the lifespan
  • Reviews controversies over the definition of metabolic syndrome in adults and children
  • Addresses current knowledge regarding the epidemiology of insulin resistance in the pediatric population
  • Examines views on prenatal and early childhood environment to the development of insulin resistance
  • Explores pathophysiology, with reviews of the techniques used to study insulin resistance
  • Provides an overview of current knowledge of the molecular and physiologic mechanisms of insulin resistance, including the contributions of adipose tissue and biochemical mediators
  • Discusses the relationship between insulin resistance and cardiovascular, endothelial, liver and gonadal disorders
  • Explores the impact of exercise and weight loss medications on insulin resistance

Part of the book series: Contemporary Endocrinology (COE)

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Table of contents (16 chapters)

  1. Front Matter

    Pages i-xi
    Download chapter PDF

  3. Pathophysiology

    1. Molecular Mechanisms of Insulin Resistance

      • Boris Draznin
      Pages 95-108

    2. Techniques Used to Assess Insulin Action

      • Michael J. Pagliassotti, Kyle T. Pfaffenbach, Tracy J. Horton
      Pages 109-124

    3. Adiposity is The Enemy: Body Composition and Insulin Sensitivity

      • Janine Higgins, William T. Donahoo
      Pages 125-147

    4. Ectopic Fat Deposition, Adiponectin and Insulin Resistance in Obese Adolescents

      • Anna M. G. Cali, Sonia Caprio
      Pages 149-159

    5. Mediators of Insulin Resistance

      • Rocio I. Pereira, David M. Maahs
      Pages 161-177

    6. Insulin Resistance and the Pathogenesis of Cardiovascular Disease

      • Ramzi Ajjan, Mark T. Kearney, Peter J. Grant
      Pages 179-205

    7. Insulin Resistance and Cardiovascular Disease

      • Cecilia C. Low Wang
      Pages 207-228

    8. The Liver and Insulin Resistance: The Important Convergence of Endocrinology and Hepatology

      • Charissa Y. Chang, Kerry Whitt, Zhenqi Liu, Stephen H. Caldwell
      Pages 229-244

    9. Polycystic Ovary Syndrome and Metabolic Syndrome

      • Marie-Hélène Pesant, Jean-Patrice Baillargeon
      Pages 245-261

  4. Treatment

    1. Effects of Exercise in Metabolic Syndrome and Diabetes: A Central Role for Insulin Sensitivity

      • Irene E. Schauer, Judith G. Regensteiner, Jane E. B. Reusch
      Pages 265-299

    2. Weight Loss Medications and the Metabolic Syndrome

      • Linda L. Buckley, Daniel Berressen
      Pages 301-322

  5. Back Matter

    Pages 323-331
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Keywords

About this book

In the mid 1990s, Drs. Gerald Reaven identified a constellation of clinical findings, known variously as the metabolic syndrome, syndrome X, insulin resistance s- drome or insulin resistance-related disorders, that are associated with an increased risk of heart disease and diabetes. Interest in this topic grew rapidly, culminating in the publication by this series of the book, Insulin Resistance and the Metabolic Syndrome X, edited by Drs. Reaven and Laws in 1999. Since the original publication of that now classic volume, the world’s population has continued to become more obese and sedentary and the prevalence of disorders related to insulin resistance has continued to increase throughout the developed and developing world. Of great concern in the last decade is the extension of these deleterious lifestyle patterns to the pediatric population, leading to both obesity and the appearance of insulin resistance-related disorders in youth as well as adults. Today, about one in three children and adolescents in the United States is overweight or obese, and this prevalence approaches one in two among adolescents in certain minority groups. In addition, components of this cardiovascular risk constellation are now being recognized in young adults, adolescents, and even children. Youth are increasingly developing type 2 diabetes, fatty liver disease, hypertriglyceridemia, hypertension, polycystic ovarian syndrome, sleep apnea, orthopedic and psychiatric complications, as well as other complications of obesity and insulin resistance.

Reviews

From the reviews:

"The editors have gathered world experts in this recently recognized problem in children as well as in the adult disease. Molecular mechanisms and disturbances in physiologic functioning are well covered and need appreciation by comprehensive therapists. Contributors to this book make this learning seem to be easy." (William H Wehrmacher, Comprehensive Therapy, December, 2008)

"Editors Philip Zeitler and Kristen Nadeau have assembled a comprehensive and insightful textbook on the timely topic of insulin resistance and the pediatric antecedents of insulin resistance that lead to adult diseases such as diabetes and cardiovascular disease. … Many chapters include excellent tables and figures. … overall, the book is worth the investment in time and money for those with either research or clinical interests in this area." (Lori Laffel, The New England Journal of Medicine, Vol. 360 (20), May, 2009)

“This volume is part of the Series Contemporary Endocrinology. … The book has 3 parts. … Clearly written, it is recommended to pediatric endocrinologists and nutritionists.” (Pediatric Endocrinology Reviews, Vol. 7 (4), June, 2010)

“Insulin Resistance: Childhood Precursors and Adult Disease, edited by Philip S. Zeitler and Kristen J. Nadeau, provides a timely and comprehensive overview of insulin resistance in children, and the clustering of associated metabolic and cardiovascular risk factors known as the metabolic syndrome. … this book would be a useful resource for any primary care physician or pediatric subspecialist. … a helpful resource for any physician seeking to expand his or her understanding of current concepts of insulin resistance and related co-morbid conditions in childhood.” (Stavra A. Xanthakos, Practical Gastroenterology, April, 2009)

Editors and Affiliations

  • Department of Pediatrics, University of Colorado Denver, Aurora, USA

    Philip Scott Zeitler, Kristen J. Nadeau

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