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  • © 2012

Targeted Therapeutics in Melanoma

  • Describes both established signal transduction inhibitors as well as emerging molecularly-guided immunotherapies
  • Places exciting developments in basic biological understanding into a practical clinical context
  • The first book on melanoma devoted entirely to targeted therapeutics
  • Includes the most up-to-date data from current clinical Phase I-III trials
  • Written by high-profile authors representing the world’s leaders in their field
  • Includes supplementary material: sn.pub/extras

Part of the book series: Current Clinical Oncology (CCO)

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Table of contents (18 chapters)

  1. Front Matter

    Pages i-xiv
  2. Advances in Melanoma Biology

    1. Front Matter

      Pages 1-1
    2. Molecular Targets and Subtypes in Melanoma

      • Michael A. Davies
      Pages 3-15
    3. Melanoma Genomics

      • Mohammed Kashani-Sabet
      Pages 17-25
  3. Signaling Molecules as Molecular Targets

    1. Front Matter

      Pages 41-41
    2. KIT as a Therapeutic Target for Melanoma

      • Nageatte Ibrahim, F. Stephen Hodi
      Pages 43-61
    3. Targeted Inhibition of B-Raf

      • Paul B. Chapman, Keith Flaherty
      Pages 63-76
    4. The Notch and β-Catenin Pathways

      • John T. Lee, Meenhard Herlyn
      Pages 77-87
    5. STAT3 and Src Signaling in Melanoma

      • Maciej Kujawski, Gregory Cherryholmes, Saul J. Priceman, Hua Yu
      Pages 89-105
    6. Targeting Apoptotic Pathways in Melanoma

      • Peter Hersey, Xu Dong Zhang
      Pages 125-153
    7. Anti-Angiogenesis Therapy in Melanoma

      • Daniel S. Chen
      Pages 155-184
  4. Rational Immunotherapy Approaches in Melanoma

    1. Front Matter

      Pages 185-185
    2. Melanoma Antigens Recognized by T Lymphocytes

      • Nicolas van Baren, Jean-François Baurain, Francis Brasseur, Pierre G. Coulie
      Pages 187-205
    3. Melanoma Vaccines

      • Pedro Romero, Daniel E. Speiser
      Pages 207-232
    4. Adoptive Cell Therapy for the Treatment of Metastatic Melanoma

      • Jessica Ann Chacon, Patrick Hwu, Laszlo G. Radvanyi
      Pages 233-272
    5. Anti-CTLA-4 Monoclonal Antibodies

      • Arvin S. Yang, Jedd D. Wolchok
      Pages 273-289
    6. Anti-PD-1 and Anti-B7-H1/PD-L1 Monoclonal Antibodies

      • Evan J. Lipson, Janis M. Taube, Lieping Chen, Suzanne L. Topalian
      Pages 291-306
    7. Treatment of Melanoma with Agonist Immune Costimulatory Agents

      • Andrew Weinberg, Robert H. Vonderheide, Mario Sznol
      Pages 307-331

About this book

Melanoma is an increasingly important public health problem. Although the cause of most malignant melanomas – over-exposure to ultraviolet light – is well known, effective treatment has remained challenging.

The past several years have been marked by extraordinary developments in melanoma treatment in the arena of targeted therapeutics. This book describes these ground-breaking discoveries and their implications for clinical use. As melanoma biology is increasingly understood, so the development of targeted therapies for this disease is spurred ahead. This book covers both established signal transduction inhibitors and the fascinating emerging realm of molecularly-guided immunotherapies.

This benchmark book provides the most up-to-date information on the new breed of melanoma therapies. Composed of the works of major researchers and clinicians, this book offers new insights, novel approaches, and promising data for effective treatment planning. Illuminating the latest advances in the field, it is a solid resource for clinical oncologists, translational scientists, and basic cancer researchers.

Reviews

From the reviews:

“This book is a multiauthored edition, with contributors and editors who are experts in their fields regarding new therapeutic approaches for melanoma. … It is a highly technical volume and is directed toward true melanoma mavins, both clinical and laboratory research based, who continue to work at the translational interface. … I recommend this to all those clinical, translational, and laboratory investigators committed to moving the field forward in the development of treatment for melanoma.” (Janice P. Dutcher, Medical Oncology, Vol. 30, 2013)

Editors and Affiliations

  • , Pathology, University of Chicago, Chicago, USA

    Thomas F. Gajewski

  • , Melanoma Disease Center, Dana-Farber Cancer Institute, Boston, USA

    F. Stephen Hodi

Bibliographic Information

  • Book Title: Targeted Therapeutics in Melanoma

  • Editors: Thomas F. Gajewski, F. Stephen Hodi

  • Series Title: Current Clinical Oncology

  • DOI: https://doi.org/10.1007/978-1-61779-407-0

  • Publisher: Humana Totowa, NJ

  • eBook Packages: Medicine, Medicine (R0)

  • Copyright Information: Springer Science+Business Media, LLC 2012

  • Hardcover ISBN: 978-1-61779-406-3Published: 14 December 2011

  • Softcover ISBN: 978-1-62703-876-8Published: 03 March 2014

  • eBook ISBN: 978-1-61779-407-0Published: 15 December 2011

  • Series ISSN: 2364-1134

  • Series E-ISSN: 2364-1142

  • Edition Number: 1

  • Number of Pages: XIV, 378

  • Topics: Oncology, Cancer Research

Buy it now

Buying options

eBook USD 89.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book USD 119.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book USD 169.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Other ways to access