Skip to main content
SpringerLink
Log in

Peptide Modifications to Increase Metabolic Stability and Activity

  • Book
  • © 2013

Overview

Editors:
  1. Predrag Cudic

    1. Torrey Pines Institute for Molecular Stu, Port St. Lucie, USA

    View editor publications

    You can also search for this editor in PubMed   Google Scholar

  • Summarizes methods for preparation and purification of modified peptides
  • Provides step-by-step detail essential for reproducible results
  • Contains key notes and implementation advice from the experts

Part of the book series: Methods in Molecular Biology (MIMB, volume 1081)

This is a preview of subscription content, log in via an institution to check access.

Access this book

Log in via an institution
eBook USD 84.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book USD 119.00
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book USD 109.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Other ways to access

Licence this eBook for your library

Institutional subscriptions

Table of contents (13 protocols)

  1. Front Matter

    Pages i-ix
    Download chapter PDF

  2. Hantzsch Based Macrocyclization Approach for the Synthesis of Thiazole Containing Cyclopeptides

    • Adel Nefzi
    Pages 1-11

  3. The Chemical Synthesis of α-Conotoxins and Structurally Modified Analogs with Enhanced Biological Stability

    • Jayati Banerjee, Reena Gyanda, Yi-Pin Chang, Christopher J. Armishaw
    Pages 13-34

  4. Synthesis of AApeptides

    • Youhong Niu, Yaogang Hu, Haifan Wu, Jianfeng Cai
    Pages 35-46

  5. Peptoids and Peptide–Peptoid Hybrid Biopolymers as Peptidomimetics

    • Maciej J. Stawikowski
    Pages 47-60

  6. Synthesis of Side Chain N,N' -Diaminoalkylated Derivatives of Basic Amino Acids for Application in Solid-Phase Peptide Synthesis

    • Jean-Philippe Pitteloud, Nina Bionda, Predrag Cudic
    Pages 61-75

  7. Study Protein Folding and Aggregation Using Nonnatural Amino Acid p-Cyanophenylalanine as a Sensitive Optical Probe

    • Deguo Du, Haiyang Liu, Bimlesh Ojha
    Pages 77-89

  8. Adamantoylated Biologically Active Small Peptides and Glycopeptides Structurally Related to the Bacterial Peptidoglycan

    • RuĹľa Frkanec, Branka Vranešić, Srdjanka Tomić
    Pages 91-106

  9. Optimization of Physicochemical and Pharmacological Properties of Peptide Drugs by Glycosylation

    • Maria C. Rodriguez, Mare Cudic
    Pages 107-136

  10. The Maillard Reaction Induced Modifications of Endogenous Opioid Peptide Enkephalin

    • Andreja Jakas
    Pages 137-149

  11. Solid-Phase Guanidinylation of Peptidyl Amines Compatible with Standard Fmoc-Chemistry: Formation of Monosubstituted Guanidines

    • Nina Bionda, Predrag Cudic
    Pages 151-165

  12. Stabilization of Collagen-Model, Triple-Helical Peptides for In Vitro and In Vivo Applications

    • Manishabrata Bhowmick, Gregg B. Fields
    Pages 167-194

  13. Identification of Adipokine Receptor Agonists and Turning Them to Antagonists

    • Laszlo Otvos Jr.
    Pages 195-209

  14. Peptide Detection and Structure Determination in Live Cells Using Confocal Raman Microscopy

    • Andrew C. Terentis, Jing Ye
    Pages 211-236

  15. Back Matter

    Pages 237-241
    Download chapter PDF
Back to top

Keywords

About this book

In Peptide Modifications to Increase Metabolic Stability and Activity, expert researchers in the field provide summarized methods for preparation, purification of modified peptides, and assessment of their biochemical activities. These methods and protocols include preparation of conformationally constrained peptides, modification of peptide bonds, introduction of nonproteinogenic amino acids, and alteration of peptides’ physical and biological properties by modification of the amino acid side chains and/or terminal residues. With additional chapter that describes new experimental approach for the detection of exogenous peptides within living cells using peptides labeled with heavy isotopes and confocal Raman microscopy. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.

 

Authoritative and practical, Peptide Modifications to Increase Metabolic Stability and Activity seeks to provide scientists with alternative approaches to peptide modification that many researchers may find applicable to their specific research requirements.

Editors and Affiliations

  • Torrey Pines Institute for Molecular Stu, Port St. Lucie, USA

    Predrag Cudic

Bibliographic Information

  • Book Title: Peptide Modifications to Increase Metabolic Stability and Activity

  • Editors: Predrag Cudic

  • Series Title: Methods in Molecular Biology

  • DOI: https://doi.org/10.1007/978-1-62703-652-8

  • Publisher: Humana Totowa, NJ

  • eBook Packages: Springer Protocols

  • Copyright Information: Springer Science+Business Media Newyork 2013

  • Hardcover ISBN: 978-1-62703-651-1Published: 07 September 2013

  • Softcover ISBN: 978-1-4939-6284-6Published: 23 August 2016

  • eBook ISBN: 978-1-62703-652-8Published: 07 September 2013

  • Series ISSN: 1064-3745

  • Series E-ISSN: 1940-6029

  • Edition Number: 1

  • Number of Pages: IX, 241

  • Number of Illustrations: 76 b/w illustrations, 16 illustrations in colour

  • Topics: Biochemistry, general, Nucleic Acid Chemistry

Publish with us

Policies and ethics

Back to top

Search

Navigation