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Peptide Synthesis and Applications

  • Book
  • © 2013

Overview

Editors:
  1. Knud J. Jensen

    1. IGM, Faculty of Sciences, University of Copenhagen, Frederiksberg, Denmark

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  2. Pernille Tofteng Shelton

    1. IGM, Faculty of Science, University of Copenhagen, Glostrup, Denmark

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    You can also search for this editor in PubMed   Google Scholar

  3. Søren L. Pedersen

    1. IGM, Faculty of Life Sciences, University of Copenhagen, Hørsholm, Denmark

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  • Practical methodologies for peptide synthesis
  • Provides step-by-step detail essential for reproducible results
  • Contains key notes and implementation advice from the experts
  • Includes supplementary material: sn.pub/extras

Part of the book series: Methods in Molecular Biology (MIMB, volume 1047)

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Table of contents (17 protocols)

  1. Front Matter

    Pages i-x
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  2. Solid-Phase Peptide Synthesis: An Introduction

    • Knud J. Jensen
    Pages 1-21

  3. Linkers, Resins, and General Procedures for Solid-Phase Peptide Synthesis

    • Pernille Tofteng Shelton, Knud J. Jensen
    Pages 23-41

  4. Peptide Release, Side-Chain Deprotection, Work-Up, and Isolation

    • Søren L. Pedersen, Knud J. Jensen
    Pages 43-63

  5. Synthesis of Peptides Using Tert-Butyloxycarbonyl (Boc) as the α-Amino Protection Group

    • Søren W. Pedersen, Christopher J. Armishaw, Kristian Strømgaard
    Pages 65-80

  6. Sequential Formation of Regioselective Disulfide Bonds in Synthetic Peptides with Multiple Disulfide Bonds

    • Fazel Shabanpoor, Mohammed Akhter Hossain, Feng Lin, John D. Wade
    Pages 81-87

  7. Synthesis of Cyclic Disulfide-Rich Peptides

    • Muharrem Akcan, David J. Craik
    Pages 89-101

  8. Preparation of C-terminally Modified Chemokines by Expressed Protein Ligation

    • Lars Baumann, Max Steinhagen, Annette G. Beck-Sickinger
    Pages 103-118

  9. Synthesis of C-Terminal Peptide Thioesters Using Fmoc-Based Solid-Phase Peptide Chemistry

    • Pernille Tofteng Shelton, Knud J. Jensen
    Pages 119-129

  10. Backbone Amide Linker Strategy: Protocols for the Synthesis of C-Terminal Peptide Aldehydes

    • Pernille Tofteng Shelton, Knud J. Jensen
    Pages 131-139

  11. Synthesis of N-Methylated Peptides: On-Resin Methylation and Microwave-Assisted Couplings

    • Renée Roodbeen, Knud J. Jensen
    Pages 141-149

  12. Synthesis of Antimicrobial Peptoids

    • Paul R. Hansen, Jens K. Munk
    Pages 151-159

  13. Synthesis of Lipidated Peptides

    • Federica Rosi, Gemma Triola
    Pages 161-189

  14. Solid-Phase Synthesis of Phosphopeptides

    • Kim B. Højlys-Larsen, Knud J. Jensen
    Pages 191-199

  15. Synthesis of O-Glycopeptides and Construction of Glycopeptide Microarrays

    • Ola Blixt, Emiliano Cló
    Pages 201-214

  16. Instruments for Automated Peptide Synthesis

    • Søren L. Pedersen, Knud J. Jensen
    Pages 215-224

  17. Microwave-Assisted Solid-Phase Peptide Synthesis Using the Biotage Syro Wave™

    • Leila Malik, Knud J. Jensen
    Pages 225-234

  18. Microwave-Assisted Solid-Phase Peptide Synthesis Based on the Fmoc Protecting Group Strategy (CEM)

    • Grace S. Vanier
    Pages 235-249

  19. Back Matter

    Pages 251-253
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Keywords

About this book

Peptides are used ubiquitously for studies in biology, biochemistry, chemical biology, peptide based medicinal chemistry, and many other areas of research. There is a number of marketed peptide drugs, and the prospects for the development of new peptide drugs are very encouraging.  The second edition of  Peptide Synthesis and Applications expands upon the previous editions with current, detailed methodologies for peptide synthesis. With new chapters on laboratory protocols for both the specialist and the non-specialist. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and key tips on troubleshooting and avoiding known pitfalls.

 

Authoritative and practical, Peptide Synthesis and Application, Second Edition seeks to aid scientists in understanding different approaches to the synthesis of peptides by using a broad range of methods and strategies.

Editors and Affiliations

  • IGM, Faculty of Sciences, University of Copenhagen, Frederiksberg, Denmark

    Knud J. Jensen

  • IGM, Faculty of Science, University of Copenhagen, Glostrup, Denmark

    Pernille Tofteng Shelton

  • IGM, Faculty of Life Sciences, University of Copenhagen, Hørsholm, Denmark

    Søren L. Pedersen

Bibliographic Information

  • Book Title: Peptide Synthesis and Applications

  • Editors: Knud J. Jensen, Pernille Tofteng Shelton, Søren L. Pedersen

  • Series Title: Methods in Molecular Biology

  • DOI: https://doi.org/10.1007/978-1-62703-544-6

  • Publisher: Humana Totowa, NJ

  • eBook Packages: Springer Protocols

  • Copyright Information: Springer Science+Business Media, New York 2013

  • Hardcover ISBN: 978-1-62703-543-9Published: 14 August 2013

  • Softcover ISBN: 978-1-4939-6004-0Published: 27 August 2016

  • eBook ISBN: 978-1-62703-544-6Published: 15 August 2013

  • Series ISSN: 1064-3745

  • Series E-ISSN: 1940-6029

  • Edition Number: 2

  • Number of Pages: X, 253

  • Number of Illustrations: 68 b/w illustrations

  • Topics: Biochemistry, general

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