Regenerating the Heart

1. Front Matter

   Pages i-xiv

   PDF

2. Introduction

   • Ira S. Cohen, Glenn R. Gaudette

   Pages 1-3

3. Stem Cells for Regeneration of Mechanical Function

   1. Front Matter

      Pages 5-5

      PDF

   2. Inducing Embryonic Stem Cells to Become Cardiomyocytes

      • Alexander M. Becker, Michael Rubart, Loren J. Field

      Pages 7-24

   3. Regenerating Function In Vivo with Myocytes Derived from Embryonic Stem Cells

      • Priya R. Baraniak, Todd C. McDevitt

      Pages 25-36

   4. Excitation–Contraction Coupling, Functional Properties, and Autonomic and Hormonal Regulation in Human Embryonic Stem Cell Derived Cardiomyocytes

      • Oshra Sedan, Ofer Binah

      Pages 37-52

   5. Embryonic Stem Cell Derivatives for Cardiac Therapy: Advantages, Limitations, and Long-Term Prospects

      • Michal Weiler-Sagie, Lior Gepstein

      Pages 53-66

   6. Methods for Differentiation of Bone-Marrow-Derived Stem Cells into Myocytes

      • Shinji Makino, Keiichi Fukuda

      Pages 67-81

   7. Homing, Survival, and Paracrine Effects of Human Mesenchymal Stem Cells

      • Sergey Doronin

      Pages 83-109

   8. Bone Marrow Cell Therapy After Myocardial Infarction: What have we Learned from the Clinical Trials and Where Are We Going?

      • Kai C. Wollert

      Pages 111-129

   9. Evidence for the Existence of Resident Cardiac Stem Cells

      • Isotta Chimenti, Roberto Gaetani, Lucio Barile, Elvira Forte, Vittoria Ionta, Francesco Angelini et al.

      Pages 131-147

   10. Multiple Sources for Cardiac Stem Cells and Their Cardiogenic Potential

       • Antonio Paolo Beltrami, Daniela Cesselli, Carlo Alberto Beltrami

       Pages 149-171

   11. Skeletal Muscle Stem Cells in the Spotlight: The Satellite Cell

       • Zipora Yablonka-Reuveni, Kenneth Day

       Pages 173-200

   12. Regenerating Mechanical Function In Vivo with Skeletal Myoblasts

       • Todd K. Rosengart, Bishawi B. S. Muath

       Pages 201-217

   13. Methods for Inducing Pluripotency

       • Raymond L. Page, Christopher Malcuit, Tanja Dominko

       Pages 219-239

   14. Inducible Pluripotent Stem Cells for Cardiac Regeneration

       • Naama Zeevi-Levin, Joseph Itskovitz-Eldor

       Pages 241-261

   15. Induced Pluripotent Cells for Myocardial Infarction Repair

       • Timothy J. Nelson, Andre Terzic

       Pages 263-280

4. Stem Cells for Regeneration of Electrical Function

   1. Front Matter

      Pages 281-281

      PDF

   2. Substrates of Cardiac Reentrant Arrhythmias: The Possible Role of Tissue Regeneration and Replacement

      • André G. Kléber

      Pages 283-300

   3. Integration of Stem Cells into the Cardiac Syncytium: Formation of Gap Junctions

      • Peter R. Brink, Ira S. Cohen, Richard T. Mathias

      Pages 301-320

Medical research made huge strides in treating heart disease in the 20th century, from drug-eluding stents to automatic internal defibrillators. Public awareness of the dangers of heart disease has never been more pervasive. Now, though, ten years into a new millennium, scientists are gearing up for the next great challenges in tackling this pervasive condition. Cell therapy is going to be a key weapon in the fight against heart disease. It has the potential to address many cardiovascular conditions. From heart failure to atrioventricular nodal dysfunction, the young but promising field of cell therapy is set to play a significant role in developing the cures that the upcoming decades of hard work will yield.

Regenerating the Heart: Stem Cells and the Cardiovascular System organizes the field into a digestible body of knowledge. Its four sections cover mechanical regeneration, electrical regeneration, cardiac tissues and in vivo stem cell therapies. An array of talented researchers share the fruits of their labors, with chapters covering such crucial issues as the cardiogenic potential of varying stem cell types, the ways in which they might be used to tackle arrhythmias, their possible application to biological replacements for cardiac tissues such as valves, and the varying approaches used in the in vivo evaluation of stem cell therapies, including methods of delivering stem cells to the myocardium.

This comprehensive survey of an area of research with such exciting potential is an invaluable resource both for veteran stem cell researchers who need to monitor fresh developments, and for newly minted investigators seeking inspirational examples.

• Biotechnology
• Cardio
• Regenerative Medicine
• Stem Cell

From the reviews:

“Regenerating the Heart: Stem Cells and the Cardiovascular System is therefore a very welcome, insightful resource for stem cell enthusiasts yet, at the same time, digestible to researchers with a casual interest in the subject. … the book reviews recent advances, balancing technical detail, clinical consideration and directions for future research prospects. … the book offers the most complete bench to bedside appraisal to date, documenting ‘where the field has been, where it is and where it is heading’ … .” (Nicola Smart, Cardiology News, December/January, 2013)

• Health Sciences Center, Dept. Physiology & Biophysics, Stony Brook University, Stony Brook, USA

  Ira S. Cohen

• Worcester Polytechnic Institute, Worcester, USA

  Glenn R. Gaudette

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