Overview
- Collects time-tested, reproducible laboratory protocols, including tricks and hints, written by experts in the field
- Investigates specific mechanisms of pathogenesis for a wide range of bacteria
- Includes novel approaches for identifying therapeutic targets designed to control infections
Part of the book series: Methods in Molecular Biology (MIMB, volume 431)
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Table of contents (22 protocols)
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Front Matter
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Mechanisms of Bacterial Pathogenesis
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Front Matter
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Host-Pathogen Interaction
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Front Matter
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Keywords
About this book
Bacterial infections affect world health today as a leading cause of morbidity and mortality. Pathogenic bacteria routinely command a broad spectrum of niches in the human host, making an understanding of pathogenesis mechanisms crucial to the development of prophylactics and treatment for bacterial diseases. A variety of in vitro methods, in vivo animal model systems and cutting-edge genomics assays have arisen in the effort to study bacterial pathogenesis and identify potential therapeutic targets. In Bacterial Pathogenesis, in-depth methods and state-of-the-art protocols are presented for investigating specific mechanisms of pathogenesis for a wide range of bacteria. This invaluable collection includes protocols to study host-pathogen interactions, animal models of infection, and novel approaches to identifying therapeutic targets designed to control infections. Up-to-date molecular typing methods for Staphylococcus aureus and a new model of streptococcal pharyngitis in non-human primates are also included. Bacterial Pathogenesis will prove an invaluable collection for microbiologists, immunologists, cell biologists and infectious disease clinicians - and indispensable to all science researchers interested in studying pathogenic bacteria and related disease processes.
Reviews
From the reviews:
"An eclectic collection of papers ranges from those with limited general applications, to those with a much broader interest. … The additional notes in each paper are most useful, and may help those making use of these techniques avoid some of the frustrations associated with following methodologies in published journal papers. … a volume to dip into seeking inspiration for new techniques to apply to one’s own favourite organism." (Jonathan Fletcher, Microbiology Today, July, 2008)
"This book was written to bring scientists working in the field of bacterial pathogenesis up-to-date with both traditional tried-and-tested methods that have been in use for decades, and more recent technological advances and breakthroughs that have led to the development of new protocols. … On the whole this book is very informative and includes an extensive set of complex and detailed protocols. … I would recommend to anyone in the field or thinking of entering the field of bacterial pathogenesis." (Andrew Vaughan, Immunology News, August, 2008)
"The 431st volume of Methods in Molecular Biology published by Humana Press is dedicated to the problems of bacterial pathogenesis. ... Each chapter is concluded by an exhaustive list of references. ... By its high level of interest and schematic approach the book is suitable not only for scientists dealing with bacterial pathogenesis ... but it can be recommended also for graduate students in microbiology who are about to start their scientific career." (K. Tyllovâ, Folia Microbiologica, Vol. 53, November, 2008)
Editors and Affiliations
Bibliographic Information
Book Title: Bacterial Pathogenesis
Book Subtitle: Methods and Protocols
Editors: Frank R. DeLeo, Michael Otto
Series Title: Methods in Molecular Biology
DOI: https://doi.org/10.1007/978-1-60327-032-8
Publisher: Humana Totowa, NJ
eBook Packages: Springer Protocols
Copyright Information: Humana Press 2008
Hardcover ISBN: 978-1-58829-740-2Published: 31 January 2008
Softcover ISBN: 978-1-61737-751-8Published: 09 December 2010
eBook ISBN: 978-1-60327-032-8Published: 04 February 2008
Series ISSN: 1064-3745
Series E-ISSN: 1940-6029
Edition Number: 1
Number of Pages: XVI, 320
Number of Illustrations: 37 b/w illustrations, 10 illustrations in colour
Topics: Medical Microbiology, Microbiology, Immunology, Cell Biology