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Essential Concepts in Toxicogenomics

  • Book
  • © 2008

Overview

Editors:
  1. Donna L. Mendrick

    1. Gene Logic Inc, Gaithersburg, USA

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    You can also search for this editor in PubMed   Google Scholar

  2. William B. Mattes

    1. The Critical Path Institute, Rockville, USA

    View editor publications

    You can also search for this editor in PubMed   Google Scholar

  • Includes contributions from experts in fields as diverse as the pharmaceutical industry, biotechnology companies, regulatory agencies, non-profit organizations and academia
  • Covers the many uses of toxicogenomics spanning its predictive application, use in mechanistic analysis, and consideration for risk assessment
  • Discusses the issues that currently limit its universal acceptance including cross species correlations, regulatory uncertainty and biomarker validation

Part of the book series: Methods in Molecular Biology (MIMB, volume 460)

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Table of contents (12 protocols)

  1. Front Matter

    Pages i-xi
    Download chapter PDF

  2. Toxicogenomics and Classic Toxicology: How to Improve Prediction and Mechanistic Understanding of Human Toxicity

    • Donna L. Mendrick
    Pages 1-22

  3. Use of Traditional End Points and Gene Dysregulation to Understand Mechanisms of Toxicity: Toxicogenomics in Mechanistic Toxicology

    • Wayne R. Buck, Jeffrey F. Waring, Eric A. Blomme
    Pages 23-44

  4. Quality Control of Microarray Assays for Toxicogenomic and In Vitro Diagnostic Applications

    • Karol L. Thompson, Joseph Hackett
    Pages 45-68

  5. Role of Statistics in Toxicogenomics

    • Michael Elashoff
    Pages 69-87

  6. Predictive Toxicogenomics in Preclinical Discovery

    • Scott A. Barros, Rory B. Martin
    Pages 89-112

  7. In Vivo Predictive Toxicogenomics

    • Mark W. Porter
    Pages 113-143

  8. Bioinformatics: Databasing and Gene Annotation

    • Lyle D. Burgoon, Timothy R. Zacharewski
    Pages 145-157

  9. Microarray Probe Mapping and Annotation in Cross-Species Comparative Toxicogenomics

    • John N. Calley, William B. Mattes, Timothy P. Ryan
    Pages 159-183

  10. Toxicogenomics in Biomarker Discovery

    • Marc F. DeCristofaro, Kellye K. Daniels
    Pages 185-194

  11. From Pharmacogenomics to Translational Biomarkers

    • Donna L. Mendrick
    Pages 195-220

  12. Public Consortium Efforts in Toxicogenomics

    • William B. Mattes
    Pages 221-238

  13. Applications of Toxicogenomics to Nonclinical Drug Development: Regulatory Science Considerations

    • Frank D. Sistare, Joseph J. DeGeorge
    Pages 239-261

  14. Back Matter

    Pages 263-277
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Keywords

About this book

The field of toxicogenomics has been growing quickly, yet with rapid growth comes the need to periodically reflect on the nature of the field.  Essential Concepts in Toxicogenomics collects reviews, opinion pieces and case studies from the leading experts in this dynamic field with a focus on its application to pharmaceuticals.  Topics covered include issues that affect the quality of toxicogenomics experiments, statistical approaches to their data analysis, the use of such data to build toxicogenomic models, and the utilization of genomics to identify biomarkers within the preclinical and clinical arenas. Although not in the standard Methods in Molecular Biology™ series format, this volume retains the practicality and usefulness of the highly successful series.

 

Informative and cutting-edge, Essential Concepts in Toxicogenomics is an ideal resource for pharmaceutical companies, chemical manufacturers, toxicologists, and all who must keep up-to-date on progress in this vital and important field.

Reviews

From the reviews:

"‘Essential Concepts in Toxicogenomics’ is a collections of reviews, opinion pieces and case studies written by experts in the field. … gives good coverage of whole field of toxicogenomics. … If you want to get up to steam with this area then … it is certainly worth reading this book." (James Sidaway, BTS Newsletter, Winter, 2008)

Editors and Affiliations

  • Gene Logic Inc, Gaithersburg, USA

    Donna L. Mendrick

  • The Critical Path Institute, Rockville, USA

    William B. Mattes

Bibliographic Information

  • Book Title: Essential Concepts in Toxicogenomics

  • Editors: Donna L. Mendrick, William B. Mattes

  • Series Title: Methods in Molecular Biology

  • DOI: https://doi.org/10.1007/978-1-60327-048-9

  • Publisher: Humana Totowa, NJ

  • eBook Packages: Springer Protocols

  • Copyright Information: Humana Press 2008

  • Hardcover ISBN: 978-1-58829-638-2Published: 30 May 2008

  • Softcover ISBN: 978-1-61737-688-7Published: 19 November 2010

  • eBook ISBN: 978-1-60327-048-9Published: 01 May 2008

  • Series ISSN: 1064-3745

  • Series E-ISSN: 1940-6029

  • Edition Number: 1

  • Number of Pages: XI, 277

  • Topics: Human Genetics, Pharmacology/Toxicology, Bioinformatics

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