Skip to main content
SpringerLink
Log in
Book cover

DNA Repair in Cancer Therapy

  • Book
  • © 2004

Overview

Editors:
  1. Lawrence C. Panasci

    1. Lady Davis Institute for Medical Research, Sir Mortimer B. Davis-Jewish General Hospital, McGill University, Montreal, Canada

    View editor publications

    You can also search for this editor in PubMed   Google Scholar

  2. Moulay A. Alaoui-Jamali

    1. Lady Davis Institute for Medical Research, Sir Mortimer B. Davis-Jewish General Hospital, McGill University, Montreal, Canada

    View editor publications

    You can also search for this editor in PubMed   Google Scholar

Part of the book series: Cancer Drug Discovery and Development (CDD&D)

This is a preview of subscription content, log in via an institution to check access.

Access this book

Log in via an institution
eBook USD 129.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book USD 169.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book USD 169.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Other ways to access

Licence this eBook for your library

Institutional subscriptions

Table of contents (15 chapters)

  1. Front Matter

    Pages i-xi
    Download chapter PDF

  2. Clinical Resistance to Alkylators

    • Brian Leyland-Jones
    Pages 1-7

  3. Role of Nonhomologous End-Joining and Recombinational DNA Repair in Resistance to Nitrogen Mustard and DNA Crosslinking Agents

    • Lawrence C. Panasci, Zhi-Yuan Xu, Raquel Aloyz
    Pages 9-29

  4. Repair of DNA Interstrand Crosslinks Produced by Cancer Chemotherapeutic Drugs

    • Peter J. McHugh, John A. Hartley
    Pages 31-49

  5. Chemosensitization to Platinum-Based Anticancer Drugs

    • Bertrand J. Jean-Claude
    Pages 51-71

  6. Regulation of DNA Repair and Apoptosis by p53 and Its Impact on Alkylating Drug Resistance of Tumor Cells

    • Istvan Boldogh, Kishor K. Bhakat, Dora Bocangel, Gokul C. Das, Sankar Mitra
    Pages 73-108

  7. Stress-Activated Signal Transduction Pathways in DNA Damage Response

    • Moulay A. Alaoui-Jamali, P. James Scrivens, Martin Loignon
    Pages 109-141

  8. Overcoming Resistance to Alkylating Agents by Inhibitors of O 6-Alkylguanine-DNA Alkyltransferase

    • Anthony E. Pegg, M. Eileen Dolan
    Pages 143-169

  9. Cellular Protection Against the Antitumor Drug Bleomycin

    • Dindial Ramotar, Huijie Wang, Chaunhua He
    Pages 171-196

  10. Potential Role of PARP Inhibitors in Cancer Treatment and Cell Death

    • Michèle Rouleau, Guy G. Poirier
    Pages 197-210

  11. Relationship Among DNA Repair Genes, Cellular Radiosensitivity, and the Response of Tumors and Normal Tissues to Radiotherapy

    • David Murray, Adrian C. Begg
    Pages 211-256

  12. Strand-Break Repair and Radiation Resistance

    • George Shenouda
    Pages 257-272

  13. V(D)J Recombination and DNA Double-Strand-Break Repair

    • Despina Moshous, Jean-Pierre de Villartay
    Pages 273-293

  14. Inherited Disorders of Genomic Instability and Cancer Susceptibility

    • Gary M. Kupfer
    Pages 295-321

  15. Role of BRCA1 and BRCA2 in DNA Repair and Potential Impact on Therapeutics

    • Razqallah Hakem
    Pages 323-337

  16. Genetic Variations in DNA Repair

    • Jennifer J. Hu
    Pages 339-351

  17. Back Matter

    Pages 353-363
    Download chapter PDF
Back to top

Keywords

About this book

A comprehensive review of the recent developments in DNA repair that have potential for translational and clinical applications. The authors explain in detail the various mechanisms by which cancer cells can circumvent anticancer therapy and limits its usefulness in patients. They also review the clinical impact of such novel inhibitors of DNA repair mechanisms as methylguanine-DNA-methyltransferase. Also examined are inhibitors of other DNA repair enzymes such as PARP and DNA-PK, now under development and close to clinical trials. The book captures-for both cancer researchers and practicing oncologists dealing with hallmark "relapse" or "drug resistance" phenomena on a daily basis-the many exciting new uses of DNA repair inhibitors, either alone or in combination with anticancer therapies.

Reviews

...gives a comprehensive review of the modern status of the DNA repair field for cancer researchers and clinical practitioners and provides a solid basis for in-depth study of different areas in this field...The book is a timely publication with a significant intended audience that will be served well. The book is well planned, well written, comprehensive, and addresses recent findings in the field. -Doody's Health Sciences Book Review Journal

"...extensive and extremely detailed...a comprehensive review of DNA repair." - The Annals of Pharmacotherapy

"Comprehensive and cutting-edge, for both cancer researchers and practicing oncologists dealing with the hallmark 'relapse; or 'drug resistance' phenomena on a daily basis...." Tumori

Editors and Affiliations

  • Lady Davis Institute for Medical Research, Sir Mortimer B. Davis-Jewish General Hospital, McGill University, Montreal, Canada

    Lawrence C. Panasci, Moulay A. Alaoui-Jamali

Bibliographic Information

  • Book Title: DNA Repair in Cancer Therapy

  • Editors: Lawrence C. Panasci, Moulay A. Alaoui-Jamali

  • Series Title: Cancer Drug Discovery and Development

  • DOI: https://doi.org/10.1007/978-1-59259-735-2

  • Publisher: Humana Totowa, NJ

  • eBook Packages: Springer Book Archive

  • Copyright Information: Springer Science+Business Media New York 2004

  • Hardcover ISBN: 978-1-58829-298-8Published: 19 March 2004

  • Softcover ISBN: 978-1-61737-480-7Published: 19 November 2010

  • eBook ISBN: 978-1-59259-735-2Published: 19 March 2004

  • Series ISSN: 2196-9906

  • Series E-ISSN: 2196-9914

  • Edition Number: 1

  • Number of Pages: XI, 363

  • Number of Illustrations: 50 b/w illustrations

  • Topics: Oncology

Publish with us

Policies and ethics

Back to top

Search

Navigation