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  • Book
  • © 2001

Immunotoxin Methods and Protocols

Editors:

  1. Walter A. Hall

    1. Department of Neurosurgery, University of Minnesota, Minneapolis

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Part of the book series: Methods in Molecular Biology (MIMB, volume 166)

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Table of contents (18 protocols)

  1. Front Matter

    Pages i-xi
    PDF

  2. Immunotoxin Construction and Development

    1. Front Matter

      Pages 1-1
      PDF

    2. Development and Activities of the BR96-Doxorubicin Immunoconjugate

      • Ingegerd Hellström, Karl Erik Hellström, Peter D. Senter
      Pages 3-16

    3. CD7-Specific Single Chain Fv Immunotoxins

      • Christopher A. Pennell, Mary E. Pauza
      Pages 17-29

    6. Purification and Conjugation of Type 1 Ribosome-Inactivating Proteins

      • Luigi Barbieri, Andrea Bolognesi, Fiorenzo Stirpe
      Pages 71-85

    8. Modulation of Growth Factor Receptor Expression by Irradiation for Immunotoxin Targeting

      • Ki-Uk Kim, Hsiao-Tzu Ni, Stephen R. Spellman, Kwan H. Cho, Walter C. Low, Walter A. Hall
      Pages 101-110

    10. In Vitro Studies of Ricin A-Chain-Induced Vascular Leak Syndrome

      • Alan L. Lindstrom, Christopher A. Pennell
      Pages 125-135

  3. Oncologic Applications of Immunotoxins

    1. Front Matter

      Pages 136-136
      PDF

    2. Immunotoxin Treatment of Brain Tumors

      • Walter A. Hall
      Pages 139-154

    5. Tyrosine Kinase Inhibitors Against EGF Receptor-Positive Malignancies

      • Elise A. Sudbeck, Sutapa Ghosh, Xing-Ping Liu, Yaguo Zheng, Dorothea E. Myers, Fatih M. Uckun
      Pages 193-218

    6. Targeting Tumor Vasculature Using VEGF-Toxin Conjugates

      • S. Ramakrishnan, Robert Wild, Dana Nojima
      Pages 219-234

    7. Gene Therapy With Immunotoxins

      • Daniel A. Vallera
      Pages 235-246

  4. Alternative Applications of Immunotoxins

    1. Front Matter

      Pages 247-247
      PDF
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About this book

Immunotoxins represent a new class of human therapeutics that have widespread applications and a potential that has not yet been fully recognized since they were first conceived of by Paul Ehrlich in 1906. The majority of advances in the development and implementation of immunotoxins has occurred over the last 20 years. The reasons for this use of immunotoxins in basic science and clinical research are the powerful concurrent advances in genetic engineering and receptor physiology. Recombinant technology has allowed investigators to produce sufficient quantities of a homogeneous c- pound that allows clinical trials to be performed. The identification of specific receptors on malignant cell types has enabled scientists to generate immunotoxins that have had positive results in clinical trials. As more cellular targets are identified in coming years, additional trials will be conducted in different disease states affecting still larger patient populations. Modulation of the immune system to decrease the humoral response to immunotoxins may improve their overall efficacy. As increasingly more effective compounds are generated, it will be necessary to decrease the local and systemic toxicity - sociated with these agents, and methods for doing so are presently being - veloped. The work presented in Immunotoxin Methods and Protocols focuses on three specific areas of immunotoxin investigation that are being conducted by experts throughout the world. The first section describes the construction and development of a variety of immunotoxins.
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Editors and Affiliations

  • Department of Neurosurgery, University of Minnesota, Minneapolis

    Walter A. Hall

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Bibliographic Information

  • Book Title: Immunotoxin Methods and Protocols

  • Editors: Walter A. Hall

  • Series Title: Methods in Molecular Biology

  • DOI: https://doi.org/10.1385/1592591140

  • Publisher: Humana Totowa, NJ

  • eBook Packages: Springer Protocols

  • Copyright Information: Humana Press 2001

  • Hardcover ISBN: 978-0-89603-775-5Published: 22 December 2000

  • Softcover ISBN: 978-1-61737-183-7Published: 10 November 2010

  • eBook ISBN: 978-1-59259-114-5Published: 02 February 2008

  • Series ISSN: 1064-3745

  • Series E-ISSN: 1940-6029

  • Edition Number: 1

  • Number of Pages: XI, 297

  • Topics: Immunology

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Buy it now

eBook USD 84.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book USD 109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book USD 109.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Other ways to access

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