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Xenotransplantation

Basic Research and Clinical Applications

  • Book
  • © 2002

Overview

Editors:
  1. Jeffrey L. Platt

    1. Transplantation Biology and the Departments of Surgery, Immunology, and Pediatrics, Mayo Clinic, Rochester, USA

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Table of contents (12 chapters)

  1. Front Matter

    Pages i-x
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  2. Molecular and Cellular Hurdles to Xenotransplantation

    • Jeffrey L. Platt
    Pages 1-43

  3. Pathological Responses to Xenotransplantation

    • Matilde Bustos, Jeffrey L. Platt
    Pages 45-55

  4. Natural Xenoreactive Antibodies

    • Uri Galili
    Pages 57-71

  5. Specificity of Xenoreactive Natural Antibodies

    • William Parker, Paul B. Yu, Yuko C. Nakamura
    Pages 73-85

  6. Biophysical Properties of Xenoreactive Natural Antibodies

    • William Parker, Ryan C. Fields, Yuko C. Nakamura
    Pages 87-101

  7. The Origin of Xenoreactive Natural Antibodies

    • Paul B. Yu
    Pages 103-118

  8. Synthesis of Carbohydrate Antigens Recognized by Xenoreactive Antibodies

    • Mauro S. Sandrin, Ian F. C. McKenzie
    Pages 119-137

  9. The Complement Barrier to Xenotransplantation

    • Agustin P. Dalmasso
    Pages 139-171

  10. Defects and Amplification of Costimulation Across the Species

    • Nicola Rogers, Robert Lechler
    Pages 173-197

  11. Antibody-Dependent Effects on Cellular Immunity

    • Antonello Pileggi, R. Damaris Molano, Thierry Berney, Luca Inverardi
    Pages 199-214

  12. Disordered Regulation of Coagulation and Platelet Activation in Xenotransplantation

    • Simon C. Robson
    Pages 215-246

  13. Current Applications of Cellular Xenografts

    • Albert S. B. Edge
    Pages 247-263

  14. Back Matter

    Pages 265-270
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Keywords

About this book

Internationally recognized scientists, clinicians, and technologists review and explain the fundamental molecular and cellular biology that has been applied to the emerging field of transplant immunology and xenotransplantation, and what impact these advances might optimally have on medicine and science. The authoritative experts writing here-many of whom made the basic discoveries underlying the recent advances-examine the biological and immunological hurdles to xenotransplantation, illuminating how the immune system interacts with the xenograft and laying a practical foundation for the use of genetic engineering and animal transplants in the treatment of human disease.

Reviews

"This book provides a useful and concise review of the current status of xenotransplantion and introduces the reader to the remaining required developments before effective implementation of xenotransplantation can occur...The editor and authors are recognized authorities in the field of xenotransplantation and this book is an important addition to existing literature on this topic" - Doody's Health Sciences Book Review Journal

Editors and Affiliations

  • Transplantation Biology and the Departments of Surgery, Immunology, and Pediatrics, Mayo Clinic, Rochester, USA

    Jeffrey L. Platt

Bibliographic Information

  • Book Title: Xenotransplantation

  • Book Subtitle: Basic Research and Clinical Applications

  • Editors: Jeffrey L. Platt

  • DOI: https://doi.org/10.1007/978-1-59259-166-4

  • Publisher: Humana Totowa, NJ

  • eBook Packages: Springer Book Archive

  • Copyright Information: Springer Science+Business Media New York 2002

  • Hardcover ISBN: 978-0-89603-674-1Published: 07 May 2002

  • Softcover ISBN: 978-1-61737-127-1Published: 05 November 2010

  • eBook ISBN: 978-1-59259-166-4Published: 07 May 2002

  • Edition Number: 1

  • Number of Pages: X, 270

  • Number of Illustrations: 9 b/w illustrations

  • Topics: Transplant Surgery, Theory of Medicine/Bioethics, Immunology

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