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Clinical and Forensic Applications of Capillary Electrophoresis

  • Book
  • © 2001

Overview

Editors:
  1. John R. Petersen

    1. University of Texas Medical Branch, Galveston, USA

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    You can also search for this editor in PubMed   Google Scholar

  2. Amin A. Mohammad

    1. University of Texas Medical Branch, Galveston, USA

    View editor publications

    You can also search for this editor in PubMed   Google Scholar

Part of the book series: Pathology and Laboratory Medicine (PLM)

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Table of contents (20 chapters)

  1. Front Matter

    Pages i-x
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  2. Introduction

    1. Front Matter

      Pages 1-1
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    2. Capillary Electrophoresis

      • Manjiri Lele, Subodh M. Lele, John R. Petersen, Amin Mohammad
      Pages 3-19

    3. Basic Principles and Modes of Capillary Electrophoresis

      • Harry Whatley
      Pages 21-58

  3. Protein Electrophoresis

    1. Front Matter

      Pages 59-59
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    2. Capillary Coatings for Protein Analysis

      • Kannan Srinivasan, Chris Pohl, Nebojsa Avdalovic
      Pages 61-78

    3. Clinical Serum Protein Capillary Zone Electrophoresis

      • Carl R. Jolliff
      Pages 79-91

    4. Serum and Urine Paraprotein Capillary Electrophoresis

      • Carl R. Jolliff
      Pages 93-104

    5. Cerebrospinal Fluid Protein Electrophoresis

      • John R. Petersen, Amin A. Mohammad
      Pages 105-112

    6. Lipoprotein Analysis

      • Rainer Lehmann
      Pages 113-144

    7. Clinical Analysis of Structural Hemoglobin Variants and Hb A1c, by Capillary Isoelectric Focusing

      • James M. Hempe, Alfonso Vargas, Randall D. Craver
      Pages 145-163

  4. Metabolic Diseases

    1. Front Matter

      Pages 165-165
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    2. Amino Acid Analysis

      • Mary Kathryn Linde
      Pages 167-192

    3. Organic Acids

      • Kern L. Nuttall, Norberto A. Guzman
      Pages 193-208

    4. Steroids

      • Cecilia Youh, Amin A. Mohammad, John R. Petersen
      Pages 209-219

  5. Immunoassay

    1. Front Matter

      Pages 221-221
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    2. Capillary Electrophoresis Based Immunoassay

      • Bode Adesoji, Amin A. Mohammad, John R. Petersen
      Pages 223-233

  6. Molecular Diagnostics

    1. Front Matter

      Pages 235-235
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    2. Quantitation of Viral Load

      • Jill M. Kolesar
      Pages 237-260

    3. The Application of Capillary Electrophoresis in the Analysis of PCR Products Used in Forensic DNA Typing

      • Bruce R. McCord, John M. Butler
      Pages 261-284
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Keywords

About this book

Because capillary electrophoresis (CE) is driving the automation of manual and semi-manual techniques, conserves precious samples, and minimizes the use of hazardous organic chemicals, it constitutes a powerful new methodology for the clinical laboratory. In Clinical and Forensic Applications of Capillary Electrophoresis, John R. Petersen and Amin A. Mohammad, along with a panel of leading basic and clinical investigators, review those CE methods that are now replacing many routine serum and blood tests in clinical and forensic laboratories. Major areas reviewed include the coating of columns; the analysis of serum, urine, and CSF proteins and paraproteins; abnormal hemoglobins and hemoglobin Alc; peptides, amino and organic acids; therapeutic drugs; drugs of abuse; viral load; and short tandem repeats (STR). The methods discussed include capillary zone, micellar, electrokinetic, capillary gel, and nonaqueous electrophoresis. The authors show how a variety of detection methods (UV-visible, fluorescence, and MS) can be used in conjunction with CE to detect a broad array of analytes, ranging from serum proteins to PCR products to drugs of forensic importance.
Innovative and highly practical, Clinical and Forensic Applications of Capillary Electrophoresis demonstrates the power and versatility of CE-not only to develop new assays, but also to markedly simplify today's clinical and forensic laboratory methodology.

Reviews

"This book fills a niche for those curious about this technology. It would be of greatest use to those with an academic interest in capillary electrophoresis."-Doody's Health Sciences Book Review Journal

Editors and Affiliations

  • University of Texas Medical Branch, Galveston, USA

    John R. Petersen, Amin A. Mohammad

Bibliographic Information

  • Book Title: Clinical and Forensic Applications of Capillary Electrophoresis

  • Editors: John R. Petersen, Amin A. Mohammad

  • Series Title: Pathology and Laboratory Medicine

  • DOI: https://doi.org/10.1007/978-1-59259-120-6

  • Publisher: Humana Totowa, NJ

  • eBook Packages: Springer Book Archive

  • Copyright Information: Springer Science+Business Media New York 2001

  • Hardcover ISBN: 978-0-89603-645-1Published: 20 April 2001

  • Softcover ISBN: 978-1-61737-113-4Published: 25 December 2011

  • eBook ISBN: 978-1-59259-120-6Published: 20 April 2001

  • Edition Number: 1

  • Number of Pages: X, 454

  • Topics: Pathology

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