Brain Tumor Immunotherapy

1. Front Matter

   Pages i-xi

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2. Introduction to the Disease

   1. Front Matter

      Pages 1-1

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   2. Neuropathology and Molecular Pathogenesis of Primary Brain Tumors

      • Paul S. Mischel, Harry V. Vinters

      Pages 3-45

   3. Epidemiology of Primary Brain Tumors

      • Susan Preston-Martin, Faith Davis, Roberta McKean-Cowdin

      Pages 47-71

   4. Current Therapy for Primary Brain Tumors

      • John M. Duff, Pierre-Yves Dietrich, Nicolas de Tribolet

      Pages 73-87

3. Introduction to Immunotherapy of Brain Tumors

   1. Front Matter

      Pages 89-89

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   2. Immunostimulation and Immunomodulation of Brain Tumors

      • Victor C. K. Tse, Frances K. Conley

      Pages 91-99

   3. Biological Principles of Brain Tumor Immunotherapy

      • Amy B. Heimberger, Darell D. Bigner, John H. Sampson

      Pages 101-130

4. Adoptive Cellular Immunotherapy of Brain Tumors

   1. Front Matter

      Pages 131-131

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   2. Systemic T-Cell Immunotherapy for Brain Tumors

      • Gregory E. Plautz, Suyu Shu

      Pages 133-148

   3. Cytotoxic T-Lymphocytes Reactive to Patient Major Histocompatibility Complex Proteins for Therapy of Brain Tumors

      • Carol A. Kruse, David Rubinstein

      Pages 149-170

   4. Autologous Vaccine and Adoptive Cellular Immunotherapy as Treatment for Brain Tumors

      • Gary W. Wood, Frank P. Holladay

      Pages 171-189

5. Antibody-Mediated Immunotherapy of Brain Tumors

   1. Front Matter

      Pages 191-191

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   2. Anti-Idiotype Immunotherapy Strategies for Brain Tumors

      • Nai-Kong V. Cheung

      Pages 193-204

   3. Radiolabeled Antibodies for Therapy of Brain Tumors

      • Carol J. Wikstrand, Michael R. Zalutsky, Darell D. Bigner

      Pages 205-229

   4. Immunotoxin Therapy of Brain Tumors

      • Walter A. Hall

      Pages 231-247

   5. Antibodies to Adhesion Molecules for Immunotherapy of Brain Tumors

      • S. Ather Enam

      Pages 249-270

6. Tumor Vaccines and Other Strategies

   1. Front Matter

      Pages 271-271

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   2. Cytokine-Based Immuno-Gene Therapy for Brain Tumors

      • Roberta P. Glick, Terry Lichtor, Edward P. Cohen

      Pages 273-288

   3. Downregulation of Transforming Growth Factor β as Therapeutic Approach for Brain Tumors

      • Habib Fakhrai, Svetlana Gramatikova, Rohangiz Safaei

      Pages 289-305

An authoritative panel of researchers and clinicians critically reviews the entire field to provide a comprehensive guide to modern brain tumor immunotherapy and thereby enhance future research in this area. The contributors detail many of the key laboratory experiments and clinical protocols that are currently being investigated, integrate the available information from previous and ongoing research, and help define the current status of the field. Topics range from adoptive cellular and antibody-mediated immunotherapy of brain tumors to tumor vaccines and related strategies, and include many vanguard experimental strategies and immunological techniques for studying brain tumor immunotherapy. Cutting-edge and comprehensive, Brain Tumor Immunotherapy brings together all the important recent advances in our understanding of central nervous system tumor immunology and illustrates in powerful detail the many new applications now harnessing the immune response for brain tumor therapeutics.

• apoptosis
• brain
• brain tumor
• brain tumors
• cell
• central nervous system
• gene therapy
• immunotherapy
• lymphocytes
• nervous system
• neuropathology
• pathogenesis
• pathology
• tumor

"...this multiauthored book is sufficiently complete to support the notion that malignant brain tumors in situ are amenable to therapies designed to isolate, amplify, and focus aspects of the immune response with respect to these tumors...Part II, Introduction to Immunotherapy of Brain Tumors, contains two very good chapters that provide the rational bases for numerous immunotherapeutic approaches covered in the remaining 12 chapters. ...Part III, Adoptive Cellular Immunotherapy, covers the more important issue of cell-mediated immunotherapy from both active immunization and adoptive transfer of ex vivo-expanded effector lymphocytes....Part IV Antiboby-Mediated Immunotherapy, contains four concise reviews of some of the more interesting anti-body-based approaches in treating brain tumors....This text should be a very useful reference for investigators who are interested in any therapeutic modality that involves (or affects) the immune system of patients with intrinsic brain tumors."- Neuro-Oncology

"Brain Tumor Immunotherapy is a unique text in its compilation of current knowledge and experimental events from an authoritative panel of researchers and clinicians who describe the ongoing trends in immunotherapy research as promising therapeutic tools for the treatment of brain tumors....The basic concepts necessary to understanding immunotherapeutic approaches to the treatment of brain tumors are superbly presented in Part II....A concise but excellent overview of the immune system as applied to the central nervous system, this chapter presents the issues that later chapters deal with, namely heterogeneity of tumors, "restricted" immunological privilege, antigen-presenting mechanisms, and cellular immunogenic responses of the central nervous system, as well as the potential risk of allergic encephalomyelitis induction." - Journal of Neurosurgery

• School of Medicine, University of California at Los Angeles, USA

  Linda M. Liau, Donald P. Becker, Timothy F. Cloughesy

• Department of Pathology and Duke Comprehensive Cancer Center, Duke University Medical Center, Durham, USA

  Darell D. Bigner

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