The Molecular Basis of Human Cancer

1. Front Matter

   Pages i-xii

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2. Introduction

   1. Front Matter

      Pages 1-1

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   2. Cancer Epidemiology

      • William B. Coleman, Gregory J. Tsongalis

      Pages 3-22

3. Essential Concepts in Molecular Biology

   1. Front Matter

      Pages 23-23

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   2. Essential Concepts and Techniques in Molecular Biology

      • Sharon Collins Presnell

      Pages 25-42

4. Molecular Themes in Oncogenesis

   1. Front Matter

      Pages 43-43

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   2. Cancer Genes

      • John J. Reinartz

      Pages 45-64

   3. Positive Mediators of Cell Proliferation in Neoplastic Transformation

      • James N. Welch, Susan A. Chrysogelos

      Pages 65-79

   4. Inactivation of Negative Growth Regulators During Neoplastic Transformation

      • Kara N. Smolinski, Stephen J. Meltzer

      Pages 81-111

5. Mechanisms of Mutation

   1. Front Matter

      Pages 113-113

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   2. The Role of Genomic Instability in the Development of Human Cancer

      • William B. Coleman, Gregory J. Tsongalis

      Pages 115-142

   3. Chromosomes and Chromosomal Instability in Human Cancer

      • Takashi Shimamoto, Kazuma Ohyashiki

      Pages 143-158

   4. Hereditary Cancer

      • Bruce M. Boman, Lael Melchert, Jeremy Z. Fields

      Pages 159-185

6. Etiology of Human Cancers

   1. Front Matter

      Pages 187-187

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   2. Evolution of Research in Cancer Etiology

      • Lorenzo Tomatis, James Huff

      Pages 189-201

   3. Cellular Responses to Chemical Carcinogens

      • Edward L. Loechler, Bryan Henry, Kwang-Young Seo

      Pages 203-222

   4. Physical Agents in Human Carcinogenesis

      • Cynthia R. Timblin, Yvonne Janssen-Heininger, Brooke T. Mossman

      Pages 223-232

   5. Viral Mechanisms of Human Carcinogenesis

      • Felix Hoppe-Seyler, Karin Butz

      Pages 233-247

7. Human Tumor Systems

   1. Front Matter

      Pages 249-249

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   2. The Molecular Biology of Colorectal Carcinoma

      • J. Milburn Jessup, Gary Gallick, Bo Liu

      Pages 251-268

Internationally renowned basic and clinical scientists provide an account of our best current understanding of the genetics of cancer. These authoritative contributors describe in detail each of the known molecular mechanisms governing neoplastic transformation in the breast, prostate, lung, liver, colon, and skin, and in the leukemias and lymphomas. Their discussion illuminates both recent developments and established concepts in epidemiology, molecular techniques, oncogenesis, and mutation mechanisms, as well as the chemical, viral, and physical mechanisms in cancer induction.

• carcinoma
• genes
• molecular biology
• molecular mechanisms
• signal transduction

"The structure of the book is fairly conventional, with an excellent scene-setting chapter that provides a clear description of widely applied methodologies....The tumor-specific chapters are well written and will attract those with interests in particular tumor-types. The colorectal chapters is especially well written, focussing on how the genetic alterations lead to changes in signal transduction pathways, which underpin disordered growth regulation. All chapters are extensively referenced....the book is well written and should be useful to fellows just about to enter the laboratory to undertake a period of molecular research, and for those established clinicians who require a detailed update on the contribution that molecular biology has made to cancer research." - Annals of Oncology

"This is an excellent volume for both investigators in the field of oncology as well as practicing oncologists." -Quarterly Review of Biology

• Department of Pathology and Laboratory Medicine, University of North Carolina School of Medicine, Chapel Hill, USA

  William B. Coleman

• Department of Pathology and Laboratory Medicine, Hartford Hospital, Hartford, USA

  Gregory J. Tsongalis

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