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Progenitor Cell Therapy for Neurological Injury

  • Book
  • © 2011

Overview

Editors:
  1. S. Charles

    1. Medical School at Houston, Div. Pediatric Surgery, University Texas, Houston, USA

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  • The text provides an up-to-date focused review on non-embryonic progenitor cell therapeutics for neurological injuries
  • Translational barriers to adoption of progenitor based cell therapeutics is a central theme of the text
  • This is a single source for a broad overview of the status of pre-clinical proof of concept data and early translational trials using progenitor cells for neurological injury
  • Includes supplementary material: sn.pub/extras

Part of the book series: Stem Cell Biology and Regenerative Medicine (STEMCELL)

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Table of contents (9 chapters)

  1. Front Matter

    Pages i-x
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  2. Basics of Stem and Progenitor Cells

    • Matthew T. Harting
    Pages 1-18

  3. Progenitor Cell Tissue Engineering

    • Kevin R. Aroom, Brijesh S. Gill
    Pages 19-46

  4. Stem Cell Delivery Methods and Routes

    • Peter A. Walker
    Pages 47-68

  5. Neural Progenitor Cells for Traumatic Brain and Spinal Cord Injury: Endogenous Cell Rescue Versus Replacement Mechanisms

    • Shinil K. Shah, Fernando Jimenez, Peter A. Walker
    Pages 69-95

  6. Traumatic Brain Injury Pathophysiology/Models

    • Peter A. Walker, Nathan D. Allison
    Pages 97-122

  7. Traumatic Brain Injury: Relationship of Clinical Injury to Progenitor Cell Therapeutics

    • Charles S. Cox Jr., James E. Baumgartner, Linda Ewing-Cobbs, Mary-Clare Day
    Pages 123-142

  8. Cell-Based Therapy for Stroke

    • Vivek Misra, Bing Yang, Sushil Sharma, Sean Savitz
    Pages 143-161

  9. Spinal Cord Injury Pathophysiology and Progenitor Cell Therapy

    • James E. Baumgartner
    Pages 163-180

  10. Progenitor Cell Therapy for the Treatment of Central Nervous System Injury: A Review of the State of Current Clinical Trials

    • Peter A. Walker, Shinil K. Shah, James E. Baumgartner
    Pages 181-191

  11. Back Matter

    Pages 193-200
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Keywords

About this book

There are currently no reparative therapies for severe neurological injury, including brain injury, spinal cord injury and stroke. Actually, most treatments are designed simply to limit secondary damage. However, pre-clinical data supports the idea that exogenous stem and progenitor cells have the potential to promote a reparative response to severe neurological injuries. Progenitor Cell Therapy for Neurological Injury is a compilation of seminal essays that explore many unique aspects of neurological injury, focusing on the critical translational issues of cell delivery. Specifically, it discusses routes of administration, types of progenitor cells (alone and/or in combinations), timing of delivery and adjuncts to promote cell engraftment, survival and effectiveness. In addition, many chapters address measuring the effects of transplanted cells and cell tracking. The paradigms of how cell-based therapeutics affect neurological injury is changing rapidly. The developments in this field may ultimately offer realistic hope for improvement in patients with severe injuries. This book is a vital key toward unlocking those future treatments.

Reviews

From the reviews:

“This book is an example of the cumulative effort over the past few years. The purpose is to address the use of progenitor cells in the management of neurological diseases. … Neurologists, neurosurgeons, neurophysiologists, neuroscientists, and molecular biology and transplantation scientists are the intended audience. … The book is well written, referenced, and illustrated.” (Celso Agner, Doody’s Book Reviews, April, 2012)

Editors and Affiliations

  • Medical School at Houston, Div. Pediatric Surgery, University Texas, Houston, USA

    S. Charles

Bibliographic Information

  • Book Title: Progenitor Cell Therapy for Neurological Injury

  • Editors: S. Charles

  • Series Title: Stem Cell Biology and Regenerative Medicine

  • DOI: https://doi.org/10.1007/978-1-60761-965-9

  • Publisher: Humana Totowa, NJ

  • eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)

  • Copyright Information: Springer Science+Business Media, LLC 2011

  • Hardcover ISBN: 978-1-60761-964-2Published: 17 November 2010

  • Softcover ISBN: 978-1-61779-717-0Published: 27 December 2012

  • eBook ISBN: 978-1-60761-965-9Published: 25 November 2010

  • Series ISSN: 2196-8985

  • Series E-ISSN: 2196-8993

  • Edition Number: 1

  • Number of Pages: X, 200

  • Topics: Stem Cells

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