Overview
- Editors:
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Rony Seger
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Dept. Biological Regulation, Weizmann Institute of Science, Rehovot, Israel
- Presents easy-to-use, comprehensive, and fully updated techniques to study MAPKs
- Serves a wide variety of scientists, from cellular biologists and biochemists to disease specialists seeking cures to diabetes, inflammation, and cancer
- Provides tips on troubleshooting difficult aspects of the included protocols
- Includes supplementary material: sn.pub/extras
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Table of contents (32 protocols)
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Activation and Function of Components of the MAP Kinase Signaling Cascades
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- Shiri Procaccia, Sarah Kraus, Rony Seger
Pages 39-58
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- Deborah N. Chadee, John M. Kyriakis
Pages 59-73
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- Huamin Zhou, Jianming Chen, Jiahuai Han
Pages 75-89
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- Kazuhiro Nakamura, Gary L. Johnson
Pages 91-106
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- Kimberly Burkhard, Paul Shapiro
Pages 107-122
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Study of MAP Kinase Cascades as Transmitters of Membranal Receptor Signals
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Front Matter
Pages 123-123
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- Gabi Tarcic, Yosef Yarden
Pages 125-135
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- Mario Chiariello, Jose P. Vaqué, Piero Crespo, J. Silvio Gutkind
Pages 137-150
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- Colin D. White, David B. Sacks
Pages 151-165
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- Hui Zheng, Adnan Al-Ayoubi, Scott T. Eblen
Pages 167-183
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- Michelle C. Mendoza, Ekrem Emrah Er, John Blenis
Pages 185-203
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- Marzia Indrigo, Alessandro Papale, Daniel Orellana, Riccardo Brambilla
Pages 205-220
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Structure-Function Relationships and Localization of MAP Kinases
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Front Matter
Pages 221-221
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- Elizabeth J. Goldsmith, Xiaoshan Min, Haixia He, Tianjun Zhou
Pages 223-237
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- Kevin M. Sours, Natalie G. Ahn
Pages 239-255
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- Vered Levin-Salomon, Oded Livnah, David Engelberg
Pages 257-272
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- Arif Jivan, Aarati Ranganathan, Melanie H. Cobb
Pages 273-285
About this book
Mitogen-activated protein (MAP) kinase (MAPK) cascades are key signaling components that govern essentially all cellular processes evoked by any type of stimulation, and it has been well established that the malfunctioning of these cascades leads to various diseases including cancer, autoimmunity, and diabetes. In MAP Kinase Signaling Protocols, Second Edition, expert researchers fully update the popular first edition the key techniques used in the study of MAPK signaling cascades in various cellular contexts. This thorough volume explores essential topics such as activation and function of components of the MAPK signaling cascades, the study of MAPK cascades as transmitters of membranal receptor signals, structure-function relationships of MAPKs, studies on the regulation of MAPK cascades, the use of lower organisms, animal models, and human genetics in the study of MAPKs, as well as the study of MAPKs in specific systems and diseases. Written in the highly successful Methods in Molecular Biology™ series format, chapters includes introductions to their respective subjects, lists of the necessary materials, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.
Comprehensive and cutting-edge, MAP Kinase Signaling Protocols, Second Edition aims to facilitate the study of MAPKs and allow for quicker progress in our knowledge of many vital cellular processes as well as devastating diseases.
Editors and Affiliations
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Dept. Biological Regulation, Weizmann Institute of Science, Rehovot, Israel
Rony Seger