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Rodent Models of Stroke

  • Book
  • © 2010

Overview

Editors:
  1. Ulrich Dirnagl

    1. Charité Campus Mitte, Centrum für Schlaganfall-Forschung, Charité - Universitätsmedizin Berlin, Berlin, Germany

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  • Provides hands-on guidance to most relevant stroke models in rodents
  • Comprehensive guide to non-invasive imaging in rodent stroke research (MRI, optical, nuclear medicine)
  • Covers all relevant techniques to document outcome, including the little documented topic of post-stroke behavioral analysis in the mouse
  • Includes supplementary material: sn.pub/extras

Part of the book series: Neuromethods (NM, volume 47)

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Table of contents (19 protocols)

  1. Front Matter

    Pages i-xii
    Download chapter PDF

  2. From Bedside to Bench: How Clinical Reality Should Instruct Stroke Modeling

    • Pauline Patak, Dirk M. Hermann
    Pages 1-6

  3. How to Avoid Bumping into the Translational Roadblock

    • Malcolm Macleod
    Pages 7-15

  4. Modeling Focal Cerebral Ischemia in Rodents: Introduction and Overview

    • Vincent Prinz, Matthias Endres
    Pages 17-27

  5. Focal Cerebral Ischemia in the Mouse and Rat Using the Intraluminal Suture–Filament Model

    • Ludmila Belayev, Matthias Endres, Vincent Prinz
    Pages 29-40

  6. Focal Ischemia Models: Middle Cerebral Artery Occlusion Induced by Electrocoagulation, Occluding Devices, and Endothelin-1

    • I. Mhairi Macrae
    Pages 41-53

  7. Rodent Models of Thromboembolic Stroke

    • Cyrille Orset, Benoit Haelewyn, Kilian Vivien, Denis Vivien, Alan R. Young
    Pages 55-70

  8. Photochemical and Endothelin Models of Focal Brain Ischemia

    • Otto W. Witte
    Pages 71-83

  9. Housing in an Enriched Environment: A Tool to Study Functional Recovery After Experimental Stroke

    • Karsten Ruscher, Tadeusz Wieloch
    Pages 85-91

  10. Modeling Risk Factors and Confounding Effects in Stroke

    • Barry McColl, David Howells, Nancy Rothwell, Adam Denes
    Pages 93-119

  11. Effect of Anesthesia in Stroke Models

    • Richard J. Traystman
    Pages 121-138

  12. Noninvasive Brain Imaging in Small Animal Stroke Models: MRI and PET

    • Anna M. Planas
    Pages 139-165

  13. Non-invasive Optical Imaging in Small Animal Models of Stroke

    • Andreas Wunder, Jan Klohs
    Pages 167-177

  14. Behavioral Testing in Mouse Models of Stroke

    • Mustafa Balkaya, Matthias Endres
    Pages 179-197

  15. Behavioral Testing in Rodent Models of Stroke

    • Gerlinde A. S. Metz
    Pages 199-212

  16. Histology and Infarct Volume Determination

    • Clemens Sommer
    Pages 213-226

  17. Ethics of Modeling of Cerebral Ischemia in Small Animals

    • Ute Lindauer
    Pages 227-237

  18. Quality Control and Standard Operating Procedures

    • Ulrich Dirnagl
    Pages 239-248

  19. Statistics in Experimental Stroke Research: From Sample Size Calculation to Data Description and Significance Testing

    • Ulrich Dirnagl
    Pages 249-261

  20. Complexities, Confounders, and Challenges in Experimental Stroke Research: A Checklist for Researchers and Reviewers

    • Ulrich Dirnagl
    Pages 263-277
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Keywords

About this book

In view of the numerous failures of clinical trials aimed at improving stroke therapy, the role and potential benefit of experimentally modeling focal cerebral ischemia in rodents has been debated. When methods of systematic review and metaanalyis are applied, however, it turns out that experimental models actually faithfully predicted the negative outcomes of clinical trials. In addition, thrombolysis and neuroprotection by hypothermia, first described in animal models, are key examples of treatment modalities that have made it successfully into clinical practice. In Rodent Models of Stroke, an international consortium of authors aims at critically addressing the issues on a very practical level, from choosing the model and outcome measures, designing the experiment, conducting and analyzing it, to reporting it in a scientific publication. The structure and content of the book reflect both the authors’ longstanding expertise in experimental and clinical stroke research and their roles in training the scientific community in the tools of the trade. As a volume in the successful Neuromethods series, the chapters provide authoritative reviews of the most commonly used, well-honed approaches in the field today. Stimulating and easy-to-use, Rodent Models of Stroke will help its readers understand the limitations and the opportunities of modeling stroke in rodents and enable them to conduct experiments which will not only improve our understanding of the pathophysiology of this devastating disorder but also serve as the basis for developing new highly effective treatments.

Reviews

From the reviews:

“Rodent Models of Stroke by U. Dirnagl is simply the best ischemia book on principles, theory, protocols, and techniques which has been written over the past 25 years. … This book is aimed at a broad audience on ischemia research including graduate students, postgraduate scholars, junior faculty, and senior seasoned investigators. … In short, this is an ideal textbook for being a primer or a detailed reference to refer to. I highly recommend it.” (Joseph J. Grenier, Amazon.com, September, 2013)

Editors and Affiliations

  • Charité Campus Mitte, Centrum für Schlaganfall-Forschung, Charité - Universitätsmedizin Berlin, Berlin, Germany

    Ulrich Dirnagl

Bibliographic Information

  • Book Title: Rodent Models of Stroke

  • Editors: Ulrich Dirnagl

  • Series Title: Neuromethods

  • DOI: https://doi.org/10.1007/978-1-60761-750-1

  • Publisher: Humana Totowa, NJ

  • eBook Packages: Springer Protocols

  • Copyright Information: Springer Science + Business Media, LLC 2010

  • Hardcover ISBN: 978-1-60761-749-5Published: 08 July 2010

  • Softcover ISBN: 978-1-4939-5807-8Published: 23 August 2016

  • eBook ISBN: 978-1-60761-750-1Published: 22 June 2010

  • Series ISSN: 0893-2336

  • Series E-ISSN: 1940-6045

  • Edition Number: 1

  • Number of Pages: XII, 286

  • Topics: Neurosciences, Animal Models

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