Cancer and IgE

1. Front Matter

   Pages i-ix

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2. Introduction

   • Erika Jensen-Jarolim, Manuel L. Penichet

   Pages 1-11

3. The Biology of IgE: Molecular Mechanism Restraining Potentially Dangerous High Serum IgE Titres In Vivo

   • Gernot Achatz, Gertrude Achatz-Straussberger, Stefan Feichtner, Sebastian Koenigsberger, Stefan Lenz, Doris Peckl-Schmid et al.

   Pages 13-36

4. The Biology of IgE: The Generation of High-Affinity IgE Antibodies

   • Maria A. Curotto de Lafaille, Juan J. Lafaille

   Pages 37-46

5. Epidemiological Evidence: IgE, Atopy, and Solid Tumors

   • Michelle C. Turner

   Pages 47-77

6. Epidemiological Evidence: IgE, Allergies, and Hematopoietic Malignancies

   • Otoniel Martínez-Maza, Alan Duane Moreno, Wendy Cozen

   Pages 79-136

7. Mast Cells in Allergy and Tumor Disease

   • Anna Wasiuk, Victor C. de Vries, Elizabeth C. Nowak, Randolph J. Noelle

   Pages 137-158

8. The IgE Antibody and Its Use in Cancer Immunotherapy

   • Tracy R. Daniels, José A. Rodríguez, Elizabeth Ortiz-Sánchez, Gustavo Helguera, Manuel L. Penichet

   Pages 159-183

9. IgE Interacts with Potent Effector Cells Against Tumors: ADCC and ADCP

   • Sophia N. Karagiannis, Frank O. Nestle, Hannah J. Gould

   Pages 185-213

10. IgE as Adjuvant in Tumor Vaccination

    • Elisa A. Nigro, Antonio G. Siccardi, Luca Vangelista

    Pages 215-229

11. The Targets of IgE: Allergen-Associated and Tumor-Associated Molecular Patterns

    • Erika Jensen-Jarolim, Diana Mechtcheriakova, Isabella Pali-Schoell

    Pages 231-254

12. The Role of Th2-Mediated Anti-Tumor Immunity in Tumor Surveillance and Clearance

    • Ljubov Simson, Julia I. Ellyard, Christopher R. Parish

    Pages 255-275

13. Back Matter

    Pages 277-287

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Erika Jensen-Jarolim and Manuel L. Penichet 1. 1 Background Infectious diseases, being the major burden in the history of mankind worldwide th until the beginning of the 20 century, were important triggers in the understanding of immunological mechanisms. In contrast to infectious diseases, reports of all- gies and cancers were less common, but increased tremendously within the last century. Based on the US mortality data of the National Center for Health Statistics, Centers for Disease Control and Prevention 2009, a recent report from the American Cancer Society indicated that the number of cancer deaths increased approximately from 100,000 to 550,000 per year between 1930 and 2006, paralleling the increase of the total population during this period. Leading causes of death from cancer are lung and bronchus cancer, in men prostate cancer, and in women breast c- cer [1, 2]. Normalization to population size shows that the cancer death rate for most malignancies has been generally stable, although the mortality rate of certain malignancies, such as lung and bronchus cancer, has increased over the last 50 years [1-3]. In allergy, the situation is less clear, because for the time period around the turn of th the 19 century, only imprecise information is available. However, within the last 30 years the incidences of allergies has doubled not only in industrial countries, but in developing countries as well [4].

• Allergie
• Antigen
• allergy
• diseases
• immunotherapy
• infectious disease
• mortality
• prevention
• prostate cancer
• tumor
• tumor surveillance
• vaccine

From the reviews:

“The book begins by giving a brief description of the long history of observations and research … into the existence of a negative correlation between the frequency of allergies and the incidence of cancer, as well as a history of allergy research in general. … the new concept of AllergoOncology, as introduced in this book, is a provocative one … . a well-written and presented book introducing a new concept in cancer immunology, as well as a comprehensive description of IgE biology in general.” (Andrew T. Vaughan, Immunology News, February, 2011)

“This book represents a description of how IgE antibodies may play a role protecting against cancer development and progression. … The audience for this book includes oncologists, allergists, and researchers, as well as students and fellows. It has a place in any health sciences library. … It is well written and full of thoughtful points and it would be a useful addition to the library of an educational institution or to the laboratory of researchers interested in this topic.” (Marion C. Cohen, Doody’s Review Service, July, 2010)

• David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, U.S.A.

  Manuel L. Penichet

• Zentrum für Physiologie,, Medizinische Universität Wien, Wien, Austria

  Erika Jensen-Jarolim

Policies and ethics