Overview
- Covers a range of phenotyping, bioinformatics, and statistical methods required for cardiovascular genomic research
- Detailed protocols for evaluating important cardiovascular diseases in rodents
- Highlights expert insights to avoid or overcome technical difficulties phenotyping rodent models
- Includes methods for integrating genotype, gene expression, and phenotype data from rodents and humans
- Provides bioinformatics and statistical methods applicable to genomic research into many varied diseases
- Includes supplementary material: sn.pub/extras
Part of the book series: Methods in Molecular Biology (MIMB, volume 573)
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Table of contents (18 protocols)
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Front Matter
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Back Matter
Keywords
About this book
As two of the leading causes of death worldwide, heart disease and stroke represent a clear target for genomic research aimed at deciphering the genes and cellular pathways that underlie cardiovascular disease and creating improved therapies. In Cardiovascular Genomics: Methods and Protocols, experts in the field provide methods for cardiovascular phenotyping of rodent models in the first section of the volume and for statistical and bioinformatic integration of phenotype data with genome-wide genotype and expression data in the second section. Understanding these diverse methods will allow an individual laboratory to utilize these genomic methods independently or to better prepare for collaboration with scientists having expertise in other disciplines in order to uncover genes affecting cardiovascular disease. Written in the highly successful Methods in Molecular Biology™ series format, chapters include introductions to their respective topics, lists of the necessary equipment, materials, and reagents, step-by-step, readily reproducible laboratory protocols, and notes on troubleshooting and avoiding known pitfalls.
Cutting-edge and easy-to-use, Cardiovascular Genomics: Methods and Protocols will enable researchers to identify causal genes and novel molecular targets that can lead to vital new treatments for cardiovascular disease.
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Editors and Affiliations
Bibliographic Information
Book Title: Cardiovascular Genomics
Book Subtitle: Methods and Protocols
Editors: Keith DiPetrillo
Series Title: Methods in Molecular Biology
DOI: https://doi.org/10.1007/978-1-60761-247-6
Publisher: Humana Totowa, NJ
eBook Packages: Springer Protocols
Copyright Information: Humana Press 2009
Hardcover ISBN: 978-1-60761-246-9Published: 25 September 2009
Softcover ISBN: 978-1-61779-643-2Published: 07 March 2012
eBook ISBN: 978-1-60761-247-6Published: 18 September 2009
Series ISSN: 1064-3745
Series E-ISSN: 1940-6029
Edition Number: 1
Number of Pages: X, 350
Number of Illustrations: 84 b/w illustrations
Topics: Cardiology, Human Genetics, Gene Expression