Atypical Parkinsonian Disorders

1. Front Matter

   Pages i-xix

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2. What is an Atypical Parkinsonian Disorder?

   • Irene Litvan

   Pages 1-9

3. Historical Issues and Atypical Parkinsonian Disorders

   • Christopher G. Goetz

   Pages 11-21

4. Epidemiology of Progessive Supranuclear Palsy and Multiple System Atrophy

   • Adam Zermansky, Yoav Ben-Shlomo

   Pages 23-31

5. Neuropathology of Atypical Parkinsonian Disorders

   • Ian R. A. Mackenzie

   Pages 33-63

6. Animal Models of Tauopathies

   • Jada Lewis, Michael Hutton

   Pages 65-76

7. Neurodegenerative α-Synucleinopathies

   • Michel Goedert, Maria Grazia Spillantini

   Pages 77-94

8. Computer Modeling in Basal Ganglia Disorders

   • José Luis Contreras-Vidal

   Pages 95-109

9. Atypical Parkinsonian Disorders

   • Charles Duyckaerts

   Pages 111-138

10. Genetics of Atypical Parkinsonism

    • Thomas Gasser

    Pages 139-154

11. Medical History and Physical Examination in Parkinsonian Syndromes

    • Marie Vidailhet, Frédéric Bourdain, Jean-Marc Trocello

    Pages 155-162

12. Role of Neuropsychiatric Assessment in Diagnosis and Research

    • Dag Aarsland, Uwe Ehrt, Clive Ballard

    Pages 163-183

13. Added Value of the Neuropsychological Evaluation for Diagnosis and Research of Atypical Parkinsonian Disorders

    • Bruno Dubois, Bernard Pillon

    Pages 185-195

14. Role of Praxis in Diagnosis and Assessment

    • Ramón Leiguarda

    Pages 197-211

15. Role of Visuospatial Cognition Assessment in the Diagnosis and Research of Atypical Parkinsonian Disorders

    • Paolo Nichelli, Anna Magherini

    Pages 213-233

16. Role of Ocular Motor Assessment in Diagnosis and Research

    • R. John Leigh, David S. Zee

    Pages 235-253

17. Characterizing and Assessing Speech and Language Disturbances

    • Carol Frattali, Joseph R. Duffy

    Pages 255-276

18. Quality of Life Assessment in Atypical Parkinsonian Disorders

    • Anette Schrag, Caroline E. Selai

    Pages 277-286

19. Progressive Supranuclear Palsy

    • Irene Litvan

    Pages 287-308

20. Corticobasal Degeneration

    • Bradley F. Boeve

    Pages 309-334

A comprehensive review of what is known not only about the cause and treatment of atypical parksonian disorders, but also the issues that clinicians, researchers, patients, and caregivers face in dealing with them. The authors cover the basic science (history, epidemiology, genetics, pathology, nosology, computer modeling, and animal models), detailed clinical and laboratory assessments, and available diagnostic tools, including neuropsychiatric, neurologic, neuropsychologic, speech, electrophysiologic, and imaging evaluations. Current and future therapeutic approaches are also detailed, along with extensive discussions about future research directions.

• Parkinson
• SPECT
• cognition
• dementia
• magnetic resonance imaging (MRI)
• neuropathology
• rehabilitation

From the reviews:

"The present book is a comprehensive and updated review on APD by a large panel of international experts. … Practical tables and diagrams and histopathological and MRI images are found throughout the book. … an authoritative masterpiece that provides a large overview on these devastating disorders. … This modern and comprehensive volume should be interesting for all neurologists and researchers interested in parkinsonian syndromes and other movement disorders." (Emmanuel Broussolle, European Neurology, April, 2006)

• Movement Disorder Program, Department of Neurology, University of Louisville School of Medicine, Louisville

  Irene Litvan

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