Animal Models of Neurotrauma

1. Front Matter

   Pages i-xiii

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2. Animal Models for Traumatic Brain Injury

   1. Front Matter

      Pages 1-1

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   2. The Fluid Percussion Injury Rodent Model in Preclinical Research on Traumatic Brain Injury

      • Fredrik Clausen, Lars Hillered, Niklas Marklund

      Pages 3-18

   3. Focal and Restricted Traumatic Injury Models in the Rodent Brain: Limitations, Possibilities, and Challenges

      • Jesper Mogensen, Hana Malá

      Pages 19-46

   4. A Model for Research on Penetrating Traumatic Brain Injuries

      • Johan Davidsson, Mårten Risling

      Pages 47-59

   5. A Sagittal Plane Rotational Injury Rodent Model for Research on Traumatic Brain Injuries

      • Johan Davidsson, Mårten Risling

      Pages 61-75

   6. Experimental Models of Blast-Induced Neurotrauma

      • Pamela Boon Li Pun, Jia Lu

      Pages 77-92

   7. Utilization of Shock Tubes in Blast Injury Research

      • Ibolja Cernak

      Pages 93-115

   8. Introduction to Blast in the Context of Blast-Induced TBI

      • M. M. G. M. (Mat) Philippens, Simon Ouellet

      Pages 117-150

   9. The Clemedson Blast Tube

      • Johan Davidsson, Ulf Arborelius, Lars-Gunnar Ohlsson, Lizan Kawa, Kian Chye Ng, Jia Lu et al.

      Pages 151-166

3. Animal Models for Spinal Cord or Nerve Injury

   1. Front Matter

      Pages 167-167

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   2. Traumatic Peripheral Nerve Injuries: Experimental Models for Repair and Reconstruction

      • Lars B. Dahlin, Lena Stenberg, Ulrica Englund Johansson, Fredrik Johansson

      Pages 169-186

   3. CNS Regeneration in Nerve Grafts: Practical Aspects of Complete Thoracic Spinal Cord Injury in Rodents

      • Arvid Frostell, Eric Peter Thelin, Per Mattsson, Mikael Svensson

      Pages 187-198

   4. Experimental Nerve Plexus Root Avulsion and Spinal Cord Implantation

      • Thomas Carlstedt, Mårten Risling

      Pages 199-205

   5. Surgical Replantation of Avulsed Lumbosacral Ventral Roots and Urodynamic Studies in a Rhesus Macaque (Macaca mulatta) Model of Cauda Equina/Conus Medullaris Injury and Repair

      • Jaime H. Nieto, Huiyi H. Chang, Marcus Ohlsson, Una Lee, J. Pablo Villablanca, Kari L. Christe et al.

      Pages 207-220

4. Translational Aspects, Secondary Injuries, In Vitro Studies or Evaluation of Large Data Sets

   1. Front Matter

      Pages 221-221

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   2. Secondary Insults in Experimental Traumatic Brain Injury: The Addition of Hypoxia

      • Caroline Lindblad, Eric Peter Thelin

      Pages 223-242

   3. A Translational Model of Traumatic Brain Injury: Sheep Impact Acceleration

      • Robert Vink

      Pages 243-250

   4. In Vitro Trauma: Description of a Cavitation-Inducing Injury Model

      • Mattias K. Sköld, Anders Sondén

      Pages 251-262

   5. Clinically Relevant Outcome Measures for Experimental Traumatic Brain Injury (TBI) Studies

      • Denes V. Agoston, Jesse McCullough, Roxanne Aniceto, Alaa Kamnaksh, David K. Wright, Sandy R. Shultz

      Pages 263-294

This volume looks into the need for a variety of experimental models for research on traumatic brain injury (TBI) and peripheral nervous system. It also describes a number of experimental models, such as mechanical devices, that have been developed to model neurotrauma in animal experiments. The overall aim of this book is to explore the variety of models and how they are used in current research. The chapters in this book are organized in four sections and talk about animal models for TBI; animal models for spinal cord or nerve injury; and translational aspects, secondary injuries, in vitro studies, and evaluation of large data sets. In Neuromethods series style, chapters include the kind of detail and key advice from the specialists needed to get successful results in your laboratory.



Cutting-edge and comprehensive, Animal Models of Neurotrauma is a valuable resource for researchers interested in expanding their knowledge and research in this developing field.

• traumatic brain injury (TBI)
• peripheral nervous system (PNS)
• central nervous system (CNS)
• animal models
• neurotrauma
• mechanical models

• Experimental Traumatology, Department of Neuroscience, Karolinska Institutet, Stockholm, Sweden

  Mårten Risling

• Division of Vehicle Safety, Department of Mechanics and Maritime Sciences, Chalmers University of Technology, Gothenburg, Sweden

  Johan Davidsson

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