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Rat Genomics

  • Book
  • © 2019

Overview

Editors:
  1. G. Thomas Hayman

    1. Department of Biomedical Engineering, Rat Genome Database, Medical College of Wisconsin, Milwaukee, USA

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  2. Jennifer R. Smith

    1. Department of Biomedical Engineering, Rat Genome Database, Medical College of Wisconsin, Milwaukee, USA

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    You can also search for this editor in PubMed   Google Scholar

  3. Melinda R. Dwinell

    1. Department of Physiology, Rat Genome Database, Genomic Sciences and Precision Medicine Center, Medical College of Wisconsin, Milwaukee, USA

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    You can also search for this editor in PubMed   Google Scholar

  4. Mary Shimoyama

    1. Department of Biomedical Engineering, Rat Genome Database, Medical College of Wisconsin, Milwaukee, USA

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    You can also search for this editor in PubMed   Google Scholar

  • Includes cutting-edge techniques and vital background information
  • Provides detail essential for reproducible results in the lab
  • Contains key implementation advice from the experts

Part of the book series: Methods in Molecular Biology (MIMB, volume 2018)

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Table of contents (16 protocols)

  1. Front Matter

    Pages i-xv
    Download chapter PDF

  2. The Rat: A Model Used in Biomedical Research

    • Jennifer R. Smith, Elizabeth R. Bolton, Melinda R. Dwinell
    Pages 1-41

  3. Rat Genome Assemblies, Annotation, and Variant Repository

    • Monika Tutaj, Jennifer R. Smith, Elizabeth R. Bolton
    Pages 43-70

  4. Rat Genome Databases, Repositories, and Tools

    • Stanley J. F. Laulederkind, G. Thomas Hayman, Shur-Jen Wang, Matthew J. Hoffman, Jennifer R. Smith, Elizabeth R. Bolton et al.
    Pages 71-96

  5. Next Generation Transgenic Rat Model Production

    • Wanda E. Filipiak, Elizabeth D. Hughes, Galina B. Gavrilina, Anna K. LaForest, Thomas L. Saunders
    Pages 97-114

  6. Embryonic Stem Cells and Gene Manipulation in Rat

    • Masumi Hirabayashi, Akiko Takizawa, Shinichi Hochi
    Pages 115-130

  7. Protocols for Cryopreservation and Rederivation of Rat Gametes

    • Akiko Takizawa, Tomoo Eto
    Pages 131-149

  8. Fluorescent Imaging and Microscopy for Dynamic Processes in Rats

    • Ruben M. Sandoval, Bruce A. Molitoris, Oleg Palygin
    Pages 151-175

  9. Library Preparation for Multiplexed Reduced Representation Bisulfite Sequencing with a Universal Adapter

    • Yong Liu, Alison J. Kriegel, Mingyu Liang
    Pages 177-194

  10. Characterization of the Rat Gut Microbiota via 16S rRNA Amplicon Library Sequencing

    • Aaron C. Ericsson, Susheel B. Busi, James M. Amos-Landgraf
    Pages 195-212

  11. Networking in Biology: The Hybrid Rat Diversity Panel

    • Boris Tabakoff, Harry Smith, Lauren A. Vanderlinden, Paula L. Hoffman, Laura M. Saba
    Pages 213-231

  12. Using Heterogeneous Stocks for Fine-Mapping Genetically Complex Traits

    • Leah C. Solberg Woods, Abraham A. Palmer
    Pages 233-247

  13. Mapping Mammary Tumor Traits in the Rat

    • Michael J. Flister, Amit Joshi, Carmen Bergom, Hallgeir Rui
    Pages 249-267

  14. Rat Models of Metabolic Syndrome

    • Anne E. Kwitek
    Pages 269-285

  15. Genomic Research in Rat Models of Kidney Disease

    • Yoram Yagil, Ronen Levi-Varadi, Chana Yagil
    Pages 287-307

  16. Rat Models of Exercise for the Study of Complex Disease

    • Lauren Gerard Koch, Steven L. Britton
    Pages 309-317

  17. Behavioral Genetic Studies in Rats

    • Yangsu Ren, Abraham A. Palmer
    Pages 319-326

  18. Back Matter

    Pages 327-331
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Keywords

About this book

This book provides both historical perspective and practical information to support researchers either currently involved in genomic research on rats or planning to begin such a project.  In numerous chapters, a detailed protocol is provided for researchers looking to move into a new area of investigation or to leverage a new technology.  In other cases, a detailed review of existing models or a description of available resources can help the researcher find, understand, and utilize the information, the data, and the tools that they need to support their research efforts. Written as part of the highly successful Methods in Molecular Biology series, this collection includes the kind of hands-on detail necessary for success in the lab. 

Authoritative and up-to-date, Rat Genomics explores the rat as a biomedical model uniquely poised to provide the ideal combination of established experimental models, extensive physiological data, and genomic manipulability to facilitate exploration of the underlying biology.

Editors and Affiliations

  • Department of Biomedical Engineering, Rat Genome Database, Medical College of Wisconsin, Milwaukee, USA

    G. Thomas Hayman, Jennifer R. Smith, Mary Shimoyama

  • Department of Physiology, Rat Genome Database, Genomic Sciences and Precision Medicine Center, Medical College of Wisconsin, Milwaukee, USA

    Melinda R. Dwinell

Bibliographic Information

  • Book Title: Rat Genomics

  • Editors: G. Thomas Hayman, Jennifer R. Smith, Melinda R. Dwinell, Mary Shimoyama

  • Series Title: Methods in Molecular Biology

  • DOI: https://doi.org/10.1007/978-1-4939-9581-3

  • Publisher: Humana New York, NY

  • eBook Packages: Springer Protocols

  • Copyright Information: Springer Science+Business Media, LLC, part of Springer Nature 2019

  • Hardcover ISBN: 978-1-4939-9580-6Published: 29 June 2019

  • Softcover ISBN: 978-1-4939-9583-7Published: 14 August 2020

  • eBook ISBN: 978-1-4939-9581-3Published: 21 June 2019

  • Series ISSN: 1064-3745

  • Series E-ISSN: 1940-6029

  • Edition Number: 1

  • Number of Pages: XV, 331

  • Number of Illustrations: 10 b/w illustrations, 54 illustrations in colour

  • Topics: Animal Genetics and Genomics, Animal Models

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