Editors:
- Includes cutting-edge methods and protocols
- Provides step-by-step detail essential for reproducible results
- Contains key notes and implementation advice from the experts
Part of the book series: Methods in Molecular Biology (MIMB, volume 1832)
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Table of contents (19 protocols)
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Front Matter
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Biochemistry
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Front Matter
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Epigenomics
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Front Matter
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Microscopy and Cell Biology
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Front Matter
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Evolution, Development, and Diseases
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Front Matter
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About this book
This volume compiles methodologies used for detailed studies of histone variants, from their basic properties to their functional roles in chromatin and as vectors of epigenetic information. Its four sections cover experimental approaches to probe the biochemistry of histone variants and variant nucleosomes; their dynamics throughout the cell cycle and at specific genomic locations; their functional impact on chromosome organization and genome stability; and their importance in development, disease and evolution. Written in the highly successful Methods in Molecular Biology series format, chapters include lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, illustrations on the expected results, and tips on troubleshooting and avoiding known pitfalls. This anthology brings together contributions from many of the most highly recognized investigators in this community.
Cutting-edge and thorough, Histone Variants: Methods and Protocols is a valuable resource for anyone interested in exploring the experimental and collaborative possibilities in this evolving field.
Editors and Affiliations
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Institut Curie, PSL Research University CNRS, UMR3664, Equipe Labellisée Ligue contre le Cancer, Paris, France
Guillermo A. Orsi, Geneviève Almouzni
Bibliographic Information
Book Title: Histone Variants
Book Subtitle: Methods and Protocols
Editors: Guillermo A. Orsi, Geneviève Almouzni
Series Title: Methods in Molecular Biology
DOI: https://doi.org/10.1007/978-1-4939-8663-7
Publisher: Humana New York, NY
eBook Packages: Springer Protocols
Copyright Information: Springer Science+Business Media, LLC, part of Springer Nature 2018
Hardcover ISBN: 978-1-4939-8662-0Published: 03 August 2018
Softcover ISBN: 978-1-4939-9358-1Published: 10 December 2019
eBook ISBN: 978-1-4939-8663-7Published: 02 August 2018
Series ISSN: 1064-3745
Series E-ISSN: 1940-6029
Edition Number: 1
Number of Pages: XII, 359
Number of Illustrations: 19 b/w illustrations, 43 illustrations in colour
Topics: Protein Science