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Drug-Induced Liver Toxicity

  • Book
  • © 2018

Overview

Editors:
  1. Minjun Chen

    1. Division of Bioinformatics and Biostatistics, National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, USA

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    You can also search for this editor in PubMed   Google Scholar

  2. Yvonne Will

    1. Drug Safety Research and Development, Pfizer Inc., Groton, USA

    View editor publications

    You can also search for this editor in PubMed   Google Scholar

  • Includes cutting-edge techniques for the study of DILI
  • Contains key implementation advice from the experts
  • Features detail essential for labs, from basic research through to clinical action

Part of the book series: Methods in Pharmacology and Toxicology (MIPT)

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Table of contents (31 protocols)

  1. Front Matter

    Pages i-xx
    Download chapter PDF

  2. Introduction

    1. Front Matter

      Pages 1-1
      Download chapter PDF

    2. Overview of Mechanisms of Drug-Induced Liver Injury (DILI) and Key Challenges in DILI Research

      • Nabil Noureddin, Neil Kaplowitz
      Pages 3-18

  3. In Silico and Modeling Approaches

    1. Front Matter

      Pages 19-19
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    2. Detection, Elimination, Mitigation, and Prediction of Drug-Induced Liver Injury in Drug Discovery

      • Francois Pognan
      Pages 21-43

    3. Drug-Induced Liver Injury (DILI) Classification and Its Application on Human DILI Risk Prediction

      • Shraddha Thakkar, Minjun Chen, Huixiao Hong, Zhichao Liu, Hong Fang, Weida Tong
      Pages 45-59

    4. Physicochemical Properties and Structural Alerts

      • Lilia Fisk, Nigel Greene, Russ Naven
      Pages 61-76

    5. Quantitative Structure–Activity Relationship Models for Predicting Risk of Drug-Induced Liver Injury in Humans

      • Huixiao Hong, Jieqiang Zhu, Minjun Chen, Ping Gong, Chaoyang Zhang, Weida Tong
      Pages 77-100

    6. An Introduction to DILIsym® Software, a Mechanistic Mathematical Representation of Drug-Induced Liver Injury

      • Christina Battista, Brett A. Howell, Scott Q. Siler, Paul B. Watkins
      Pages 101-121

  4. In Vitro Technologies

    1. Front Matter

      Pages 123-123
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    2. Prediction of Human Liver Toxicity Using In Vitro Assays: Limitations and Opportunities

      • Franck A. Atienzar, Jean-Marie Nicolas
      Pages 125-150

    3. Use of Liver-Derived Cell Lines for the Study of Drug-Induced Liver Injury

      • Zhen Ren, Si Chen, Baitang Ning, Lei Guo
      Pages 151-177

    4. Evaluation of Drug-Induced Liver Injuries (DILI) with Human Hepatocytes: Scientific Rationale and Experimental Approaches

      • Albert P. Li
      Pages 179-197

    5. Status and Use of Induced Pluripotent Stem Cells (iPSCs) in Toxicity Testing

      • Min Wei Wong, Chris S. Pridgeon, Constanze Schlott, B. Kevin Park, Christopher E. P. Goldring
      Pages 199-212

    6. Engineered Human Liver Cocultures for Investigating Drug-Induced Liver Injury

      • Chase P. Monckton, Salman R. Khetani
      Pages 213-248

    7. Status and Future of 3D Cell Culture in Toxicity Testing

      • Monicah A. Otieno, Jinping Gan, William Proctor
      Pages 249-261

    8. Reactive Metabolite Assessment in Drug Discovery and Development in Support of Safe Drug Design

      • Axel Pähler
      Pages 263-281

    9. In Vitro Assessment of Mitochondrial Toxicity to Predict Drug-Induced Liver Injury

      • Mathieu Porceddu, Nelly Buron, Pierre Rustin, Bernard Fromenty, Annie Borgne-Sanchez
      Pages 283-300

    10. Bile Salt Export Pump: Drug-Induced Liver Injury and Assessment Approaches

      • Ruitang Deng
      Pages 301-329

    11. High Content Screening for Prediction of Human Drug-Induced Liver Injury

      • Mikael Persson
      Pages 331-343
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Keywords

About this book

This book provides a comprehensive view of the methodologies used for the study of liver toxicity encountered throughout the whole life cycle of a drug, from drug discovery, to clinical trial, post-marketing, and even clinical practice. Organized into six sections, the first section introduces the mechanisms contributing to drug-induced liver toxicity.  The second and third section explore in silico and in vitro approaches used to help mitigate hepatotoxicity liability at the early stages of drug development. The fourth section describes methodologies applied in regulatory processes, including preclinical studies, clinical trials, and post-marketing surveillance. The fifth section discusses clinical hepatotoxicity. Emerging technologies are examined in the final section. As a volume in the Methods in Pharmacology and Toxicology series, chapters include the kind of expert advice that will lead to optimal results. 

Authoritative and practical, Drug-InducedLiver Toxicity serves all those who aim to improve assessment and understanding of hepatotoxic potentials of new medications and marketed drugs.



Chapter 30 is open access under a CC BY 4.0 license via link.springer.com. 


Editors and Affiliations

  • Division of Bioinformatics and Biostatistics, National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, USA

    Minjun Chen

  • Drug Safety Research and Development, Pfizer Inc., Groton, USA

    Yvonne Will

Bibliographic Information

  • Book Title: Drug-Induced Liver Toxicity

  • Editors: Minjun Chen, Yvonne Will

  • Series Title: Methods in Pharmacology and Toxicology

  • DOI: https://doi.org/10.1007/978-1-4939-7677-5

  • Publisher: Humana New York, NY

  • eBook Packages: Springer Protocols

  • Copyright Information: Springer Science+Business Media, LLC, part of Springer Nature 2018

  • Hardcover ISBN: 978-1-4939-7676-8Published: 21 March 2018

  • Softcover ISBN: 978-1-4939-9256-0Published: 10 December 2019

  • eBook ISBN: 978-1-4939-7677-5Published: 21 March 2018

  • Series ISSN: 1557-2153

  • Series E-ISSN: 1940-6053

  • Edition Number: 1

  • Number of Pages: XX, 667

  • Number of Illustrations: 49 b/w illustrations, 70 illustrations in colour

  • Topics: Pharmacology/Toxicology

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