Molecular Pathology in Cancer Research

1. Front Matter

   Pages i-viii

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2. Molecular Diagnostics: Translation from Discovery to Clinical Practice

   • Fares Al-Ejeh, Andrew V. Biankin

   Pages 1-26

3. Biobanking in Cancer Research

   • Lisa Devereux, Heather Thorne, Stephen B. Fox

   Pages 27-49

4. Cytogenetics: Methodologies

   • Chiyan Lau

   Pages 51-66

5. Cytogenetics: Applications

   • Chiyan Lau

   Pages 67-82

6. Genomic Analysis

   • Sally M. Hunter, Amy E. McCart Reed, Ian G. Campbell, Kylie L. Gorringe

   Pages 83-106

7. Gene Expression Analysis: Current Methods

   • Zhi Ling Teo, Peter Savas, Sherene Loi

   Pages 107-136

8. Gene Expression Analysis: Applications

   • Peter Savas, Zhi Ling Teo, Sherene Loi

   Pages 137-149

9. Methods Used for Noncoding RNAs Analysis

   • Marjan E. Askarian-Amiri, Darren J. Korbie, Debina Sarkar, Graeme Finlay

   Pages 151-175

10. Applications of Non-coding RNA in the Molecular Pathology of Cancer

    • Keerthana Krishnan, Nicole Cloonan

    Pages 177-217

11. Proteomics Methods

    • Keith Ashman, Greg Rice, Murray Mitchell

    Pages 219-237

12. The Clinical Application of Proteomics

    • Keith Ashman, Murray Mitchell, Gregory Rice

    Pages 239-260

13. Analysis of DNA Methylation in Clinical Samples: Methods and Applications

    • Alexander Dobrovic

    Pages 261-277

14. Clinical Flow Cytometry for Hematopoietic Neoplasms

    • David Wu, Brent L. Wood, Jonathan R. Fromm

    Pages 279-316

15. Bioinformatics Analysis of Sequence Data

    • Anthony T. Papenfuss, Daniel Cameron, Jan Schroeder, Ismael Vergara

    Pages 317-333

16. Forgotten Resources – The Autopsy

    • Deborah Smith, Amy McCart Reed, Sunil R. Lakhani

    Pages 335-348

17. The Future of Molecular Pathology

    • John S. Mattick

    Pages 349-357

18. Back Matter

    Pages 359-369

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The aim of the book is to discuss the application of molecular pathology in cancer research, and its contribution in the classification of different tumors and identification of potential molecular targets, as well as how this knowledge may be translated into clinical practice, and the huge impact this field is likely to have in the next 5 to 10 years.

• Cancer
• Molecular
• Pathology
• Translational
• Technology
• Proteomics
• gene expression

• UQ Centre for Clinical Research, The Royal Brisbane and Women’s Hospital, University of Queensland and Pathology Queensland, Brisbane, Australia

  Sunil R. Lakhani

• Peter MacCallum Cancer Centre, University of Melbourne, Melbourne, Australia

  Stephen B. Fox

Sunil Lakhani is State Director, Anatomical Pathology, Pathology Queensland, Professor and Head, Molecular & Cellular Pathology, The School of Medicine, and Head of the Breast Group, The University of Queensland Centre for Clinical Research (UQCCR). His research team comprises scientists and practicing clinicians ensuring a translational focus to the research portfolio. His current research interests include lobular carcinoma and its variants, tumours with a basal phenotype and mechanisms of brain and distant metastases. He is a series editor for the WHO Tumour Classification Books and volume editor for the WHO Classification Tumours of the Breast (4th Ed 2012).




Stephen Fox is Director of Pathology at the Peter MacCallum Cancer Centre, Professorial Fellow at the University of Melbourne and an NH&MRC Practitioner Fellow. His research has primarily been aimed at understanding the molecular basis of cancer, with emphasis on prognosis and predictive markers of human tumours with more recent work focusing on developing and implementing clinical grade diagnostics, particularly in sequencing to match the new paradigm of personalised medicine.

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